34results about How to "Controlled slow release" patented technology

The present invention relates to one kind of biomedical material. The three-layered material includes one middle layer is cloth, net or non-woven fabric of absorbable polymer fiber, and upper and lowr porous layers of absorbable polymer material. The absorbable polymer fiber contains chitin, chitosan, their derivative or other absorbable polymer material, and the absorbable fiber reinforced multilayer film material may contains additive. The absorbable fiber reinforced multilayer film material is prepared through weaving cloth or with polymer fiber, painting polymer solution to the upper and lower sides of the cloth or net, and post-treatment. It has high strength and is suitable for use in preventing tissue adhesion.

The invention provides compound polypeptide nanometer vesicles with a skin repair function, and belongs to the technical field of cosmetics. The compound polypeptide nanometer vesicles are prepared from, by weight, 0.01-1 part of regenerated repairing active peptide, 0.01-1 part of antioxidant active peptide, 0.1-5 parts of natural moisturizing active factors, 0.01-1 part of microcirculation-promoting active ingredients, 5-20 parts of lipoid wall materials, 0.1-5 parts of cholesterol, 10-45 parts of polyhydric alcohols and 30-98 parts of water. According to the compound polypeptide nanometer vesicles, repairing components acting on different target spots are provided aiming at different repair mechanisms of the skin barrier; meanwhile, the nanometer vesicles are adopted for covering various hydrophilic and lipophilic active ingredients, a unique closed lipid bilayer structure of the vesicles is utilized, the stability of the repairing compound is significantly improved, the skin penetration amount is increased, slow release of the active ingredients is effectively controlled, and the repairing effect is improved.

The invention discloses sterilization soil-improvement slow-release composite fertilizer. The sterilization soil-improvement slow-release composite fertilizer comprises, by weight, 20-25 parts of urea, 10-15 parts of ammonium biphosphate, 10-20 parts of potassium phosphate, 5-10 parts of potassium sulfate, 8-12 parts of sodium silicate, 4-6 parts of magnesium phosphate, 7-9 parts of calcium chloride, 0.2-0.4 parts of zinc ammonium phosphate, 0.1-0.3 parts of copper carbonate, 0.1-0.2 parts of manganese ammonium phosphate, 0.4-0.6 parts of potassium borate, 0.3-0.5 parts of ferric sulfate, 0.2-0.4 parts of sodium molybdate, 20-25 parts of sodium alginate, 35-45 parts of a coating material, 5-10 parts of cassava slag, 5-8 parts of furfural slag, 10-20 parts of chicken manure, 5-10 parts of carbonized rice husk, 10-15 parts of humic acid, 10-15 parts of straws, 5-8 parts of plant ash, 0.2-0.5 parts of biological fungi, 4-6 parts of thermopsine and 3-5 parts of Artemisia argyi powder. The invention also discloses a preparation method of the sterilization soil-improvement slow-release composite fertilizer.

The invention relates to a paclitaxel-loaded sustained release nano-fibre material which comprises the components of bio-degradable polymer material and pure paclitaxel, the mol ratio of which is 1.33 to 10. The diameter of the nano-fibre is 90nm to 1.44micrometer, and the drug-loading rate can be regulated within the range of 0 percent to 100 percent. The preparation of the nano-fibre comprises the steps as follows: (1) the bio-degradable polymer material is solved in organic solvent and stirred to be solved completely to obtain lamella spinning solution A; (2) the white pure paclitaxel powder is solved in trifluoroethanol and stirred to be solved completely to obtain core spinning solution B; (3) clear transparent solutions A and B are respectively added into two injectors; the speed of a microinjection pump, the voltage of a static generator and the receiving distance between a grounded aluminum foil and a spinning needle are adjusted, and unordered drug-loaded nano-fibre is obtained by a coaxial electrostatic spinning technology. A nanometer control release system composed by the drug-loaded nano-fibre effectively controls the sustained release of the drug and is applied to the preparation of the drug for remedying malignant tumor.

The invention discloses a sustained-release mixed fertilizer. The sustained-release mixed fertilizer comprises the following raw materials in parts by weight: 30 to 40 parts of urea, 15 to 25 parts of monopotassium phosphate, 10 to 20 parts of potassium silicate, 3 to 5 parts of magnesium sulfate, 8 to 10 parts of calcium chloride, 0.2 to 0.4 part of zinc sulfate, 0.3 to 0.5 part of copper nitrate, 0.5 to 1.5 parts of sodium borate, 0.1 to 0.3 part of ferric chloride, 0.1 to 0.3 part of manganese sulfate, 0.3 to 0.5 part of ammonium molybdate, 22 to 29 parts of sodium alginate, 40 to 50 parts of coating material, 5 to 10 parts of biochar, 10 to 15 parts of soybean meal, 10 to 15 parts of humic acid, 10 to 15 parts of straw, 8 to 12 parts of plant ash, and 5 to 7 parts of Gaotouwu powder. The invention also discloses a preparation method of the sustained-release mixed fertilizer. The sustained-release mixed fertilizer can control various elements to be released slowly, can improve the soil and can be used for sterilization and weed control, the coating material can be biologically degraded, and the environment can be protected.

The invention discloses an environment-friendly slow releasing compound fertilizer which comprises the following raw materials by weight part: 20-40 parts of urea, 20-40 parts of ammonium dihydrogen phosphate, 30-50 parts of potassium phosphate, 0.4-0.5 part of sodium borate, 0.1-0.2 part of ferric chloride, 0.1-0.3 part of manganese ammonium phosphate, 0.3-0.4 part of potassium molybdate, 0.2-0.4 part of copper sulfate, 0.1-0.3 part of zinc sulfate, 8-10 parts of calcium chloride, 4-6 parts of magnesium sulfate, 8-12 parts of kieselguhr, 35-45 parts ofcoating material, 10-12 parts of bean pulp, 5-8 parts of rape seed cake, 10-15 parts of livestock manure, 5-6 parts of mushroom dreg, 5-10 parts of plant ash, 4-8 parts of peanut dreg, 10-20 parts of humic acid and 1-3 parts of biochar. The environment-friendly slow releasing compound fertilizer can efficiently control all elements to slowly release and can be easily degraded; the soil can be improved; the soil moisture can be kept; the environment can be protected.

The invention relates to a soil improvement slow-release compound fertilizer and a preparation method thereof. The compound fertilizer is prepared from the following raw materials by weight: 30-40 parts of zeolite, 10-15 parts of corn cob, 10-15 parts of wheat straw, 5-10 parts of animal dung, 5-8 parts of plant ash, 9-11 parts of oyster powder, 10-13 parts of seaweed meal, 3-5 parts of humic acid, 7-10 parts of urea, 8-10 parts of alginate, 3-5 parts of potassium sulfate, 3-5 parts of ammonium dihydrogen phosphate, 3-5 parts of potassium phosphate, 3-5 parts of sodium silicate, 3-5 parts of calcium chloride, 3-5 parts of potassium nitrate, 1-2 parts of trace elements, 1-2 parts of vitamin, and 10-15 parts of amino acid powder. The soil improvement slow-release compound fertilizer provided by the invention has a simple making method, can improve soil, maintain soil water content, activate rapid propagation of soil microorganisms, and reduce soil saline-alkali harms, also can control slow release of the elements, and the coating material is biodegradable, thus protecting the environment.

The invention relates to a semaglutide contained oral prolonged-release preparation and a preparation method thereof. The semaglutide contained oral prolonged-release preparation is characterized in that a drug active component is semaglutide as a GLP-1 analogue and is also prepared from a sulfonylurea, biguanide or thiazolidinedione blood sugar lowering drug which has the synergistic effect withthe semaglutide; the drug active component is wrapped with a sustained release carrier to prepare a sustained release microsphere, and then the sustained release microsphere is mixed and pressed witha pharmaceutically acceptable auxiliary material to form a tablet with a certain shape for orally use, so that the long-term sustained release effect is exerted. By adopting the prepared oral prolonged-release preparation, the conventional administration way of a polypeptide drug is changed, the action time of the polypeptide drug is prolonged, the medication compliance of a patient with diabetesmellitus is obviously improved, and the therapeutic effect is improved.

The invention provides a preparation method of a micro / nanofiber sustained release preparation. The preparation method of the micro / nanofiber sustained release preparation comprises the following steps of: dissolving medicaments in an organic solvent, then adding modified mesoporous silica nano particles, and incubating; separating solids; dispersing the solids into the organic solvent, dissolving degradable high molecule polymers into the organic solvent, and mixing the two solutions; and spinning the mixed solution by an electrostatic spinning method, thereby obtaining the micro / nanofiber sustained release preparation. The micro / nanofiber sustained release preparation prepared through the preparation method can effectively control the slow release of medicaments, and the degradable high molecule polymers can degrade automatically; the preparation is non-toxic, has no immunogenicity, has good biocompatibility, improves the curative effect, and reduces the side effects; and different medicaments can be packaged by utilizing the preparation method, and meanwhile fiber supports for packaging different medicaments can be obtained; the long-time release of the medicaments has important significance clinically, and the method possibly become an ideal technical platform for controlling and releasing the medicament for a long time.

The invention relates to a micro / nanometer fiber slow release preparation for treating cicatrices and a preparation method thereof. The micro / nanometer fiber slow release preparation is a complex consisting of panaxoside Rg3 and degradable high molecular polymer fibers, wherein the panaxoside Rg3 is dispersed in the degradable high molecular polymer fibers in a non-crystal form, and accounts for 0.1 to 50 percent of the mass of the complex; and the diameters of the degradable high molecular polymer fibers are between 5 nanometers and 10 micrometers. The method for preparing the micro / nanometer fiber slow release preparation comprises the following steps of: dissolving the panaxoside Rg3 and degradable high molecular polymer in an organic solvent to form mixed solution, spinning the mixed solution in a method of electrostatic spinning, and drying under vacuum to prepare the micro / nanometer fiber slow release preparation. By the micro / nanometer fiber slow release preparation, the release concentration and action time of active medicaments of the panaxoside Rg3 at local parts of the cicatrices are improved, the availability of the medicaments is improved, the long-term release of the medicaments is realized, and the requirement of the panaxoside Rg3 in clinical treatment is met, so the micro / nanometer fiber slow release preparation has the characteristics of high adaptability, simple process, low cost, high repeatability and the like.

The invention provides a formula and preparation method of microcapsules prepared from deer horns and pilose antlers of sika deers. The preparation method comprises the following steps of performing cleaning; performing drying; performing coarse crushing; performing superfine crushing; compounding core material mixed liquor; compounding wall material mixed liquor; performing embedding; performing curing; performing cleaning; performing drying; and performing packaging. The formula of the microcapsules comprises the components of the deer horns and the pilose antlers of the sika deers, sodium alginate, sucrose fatty acid ester, sodium tripolyphosphate, carboxymethyl chitosan and calcium chloride. According to the formula disclosed by the invention, the dispersibility, the stability, the safety, the bacterium resistance and the oxidation resistance of micro powder made from the deer horns and the pilose antlers of the sika deers can be improved, and besides, the mechanical strength of the microcapsules prepared from the deer horns and the pilose antlers of the sika deers is strengthened. According to the formula disclosed by the invention, the deer horns and the pilose antlers of the sika deers are in superfine crushing through a technique and are prepared into the microcapsules; and therefore, sufficient absorption of nutrient components of the microcapsules by human bodies can be improved, bad smell of the deer horns and the pilose antlers can also be concealed, the stability of products is improved, and slow release of the nutrient components is controlled.

The invention discloses a teniposide solid lipid nanoparticle and a preparation method thereof in industrial application. The teniposide solid lipid nanoparticle comprises an effective treatment dose of teniposide, a lipid material and an emulsifier, has smaller grain diameter, high entrapment rate and good stability, improves the solubility and the stability of the teniposide, reduces the toxicity of the teniposide, prolongs the cycle time of medicaments in blood and improves the therapeutic index of the medicaments, thereby having the characteristics of low toxicity and irritability and high efficiency in clinical application.

The invention relates to a preparation method of a MOF compound biological enzyme wound healing agent. The method comprises the following steps: 1) synthesizing MOF; 2) compounding MOF and a biological enzyme; and 3) performing fibrin gel wrapping. MOF can use the peroxidase-like activity function to convert H2O2 into highly toxic .OH for antibacterial application; glucose oxidase can continuouslyconvert non-toxic glucose into abundant gluconic acid and H2O2, the gluconic acid can reduce the pH value from 7 to 3-4, so that the peroxidase-like activity of the MOF can be significantly activated; H2O2 can provide the conversion raw material; and fibrin gel can effectively control the slow release of drugs to achieve the purpose of long-term treatment, and promote wound healing.

The invention discloses an edible mushroom matrix synergist and a preparation method thereof. The matrix synergist disclosed by the invention is composed of zeolite powder, wood vinegar, compound sodium nitrophenolate, monopotassium phosphate, magnesium sulfate and sodium chloride, and can achieve the effects of providing mineral substances and trace elements needed by edible mushrooms, controlling slow release of nutrients such as the wood vinegar and the like, promoting growth and development of mycelia and fruiting bodies and improving the biological transformation efficiency of the culture. The matrix synergist disclosed by the invention is applied in a form of mixing the culture material (base), is very simple and convenient in application, low in price, small in addition amount, safeand pollution-free, can achieve effects of shortening the cultivation cycle of the edible mushrooms and increasing the yield of fruiting bodies of the edible mushrooms, and has application and popularization prospects in production.

The invention discloses a method for preparing antibacterial coating by mugwort, mugwort oil is used for microcapsule coating, solid mugwort oil is prepared and used in a core layer and a shell layer of core-shell emulsion polymerization, a cross-linking agent is used for core-shell cross linking, the mugwort oil is controlled to release slowly, and nanometer materials and a cationic emulsifier are used for enhancing the antibacterial effect. The method for preparing the antibacterial coating by the mugwort solves the technical problems that the mugwort oil is coated, the solid mugwort oil is formed and and used in the core layer and the shell layer of core-shell type acrylic resin, the nanometer materials, the cationic emulsifier and a natural antibacterial agent are used for achieving a synergistic effect, the mugwort oil is controlled to release slowly, and the antibacterial property of the acrylic resin is improved.

The invention provides an artificial culture method of breams, and belongs to the field of aquaculture, the method comprises pond selection, pond preparation, fry stocking, feeding management and water quality management; photosynthetic bacteria are inoculated in a pond before stocking fries, wherein the photosynthetic bacteria are obtained by a gradient cultivation method; the bream fries are fedwith a compound feed during culture, the compound feed comprises a phagostimulant, the cysteamine hydrochloride in the phagostimulant is subjected to biological membrane coating after the following pretreatment: the cysteamine hydrochloride is dissolved in an alkaline mixed solution containing beta-cyclodextrin and chitosan, reacting, filtering, washing, and drying are carried out. According to the artificial culture method, the bream feed has good palatability, high digestibility and high safety, is favorable for enhancing the feeding desire of the breams and increasing the feeding amount ofthe breams, and promotes the growth of the breams; the photosynthetic bacteria are inoculated to the bream culture pond, so that the water quality can be purified, the immunity of the fries can be enhanced, and the survival rate of the fries can be improved.

The invention discloses an antibacterial intervention medical instrument comprising a medical instrument body, a film covering layer, a nanometer coating layer and a medicine carrying layer from inside to outside. Polyether urethane material is sewed and fixed on the medical instrument for form the film covering layer; nano-silver water solution is evenly coated on the film covering layer to form the nanometer coating layer; and medicine is added to styrene-isobutylene diblock or triblock copolymer and then divided into small blocks to be coated on the nanometer coating layer to form the medicine carrying layer. The antibacterial intervention medical instrument employs a special structure, in which the film covering layer is made from non-transparent high-polymer material having biocompatibility and the surface medicine carrying layer is polymer containing sulfo group; thrombus can be prevented and postoperative complications can be reduced; with the medicine carried with bioactivity, the medicine can be controlled to be slowly released and curing effect can be enhanced; meanwhile, antibacterial effect of the medical instrument is guaranteed by the use of the nanometer coating layer; bacterial infectious diseases caused by the medical instrument can be reduced; and patient pains can be lowered.

The invention belongs to the technical field of soil conditioners, and particularly relates to a soil conditioner for promoting acer truncatum root growth and preparation and application thereof. Thesoil conditioner for promoting acer truncatum root growth comprises biochar and bacterial manure, wherein the mass ratio of the biochar to the bacterial manure is 20-35:20-30. The soil conditioner provided by the invention not only can promote acer truncatum root growth , but also can significantly improve the growth amount of acer truncatum seedling plant height and stem diameter, improve the root-crown ratio and promote the growth and development of root system forms.

The invention provides a preparation method of a high-concentration essence master batch, relates to a master batch capable of continuously releasing fragrance, in particular to a preparation method of a high-concentration essence master batch, and belongs to the field of high polymer material processing. The perfume is prepared from the following raw materials in parts by weight: 50-70 parts of carrier resin, 10-20 parts of a flavor enhancer and 20-30 parts of a flavor enhancing absorbent. The essence master batch prepared by the invention can be applied to various thermoplastic resin carriers; compatibility with substrate, the preparation method is simple, the mechanical property of the material is not influenced, the prepared material has lasting pure fragrance and is environmentally friendly and non-toxic, the service life of a fragrant plastic product is prolonged, the process steps in the prior art are simplified under the condition that the quality is not influenced, meanwhile,the process flow in the prior art is optimized, the perfuming effect is better, and the fragrance preservation time is long.

The invention relates to the technical field of cosmetic additives, in particular to a preparation method of cosmetic antioxidant based on sparassis crispa extracts. The method comprises the followingsteps that 1, the sparassis crispa extracts are extracted from sparassis crispa sporocarp; 2, the sparassis crispa extracts, hydrogenated lecithin and idebenone are mixed and then subjected to ultrasonic treatment, and a capsule core is obtained; 3, urea and 37-40% formalin are mixed and stirred on the conditions that the pH value is 8-10, and the temperature is 60-80 DEG C, and a first solutionis obtained; n-octadecane is heated and fused and then mixed with the capsule core and an emulsifier, stirring and emulsification are conducted for 30-45 minutes on the conditions that the pH value is4-5, and the temperature is 60-70 DEG C, and a second solution is obtained; the first solution is added in the second solution, standing is conducted for 2-3 hours, then the pH value is adjusted to be 6-7, and the cosmetic antioxidant is obtained. According to the method, operation is easy, the prepared antioxidant is not prone to inactivation, and the antioxidant effect is good.

The invention relates to a calcium fortifier and the preparation process. It is characterized in that it comprises following materials according to certain proportion: yak Ultra-fine bone 86%-93%, casein phosphopeptide2%-4% and inulin 5%-10%. The process of preparing microcapsules comprises the following steps: choosing bones, freezing, pressing smash and treating at high temperature and high pressure, re-refining, centrifugal filtering, ultra-fining treatment, heartwood homogeneous emulsification, spray drying, mixing wall materials and heartwoods, preparing microcapsules through spray drying, packing and getting final products. It is characterized in that it takes special resources from northwest plateau in China, contains high content calcium, possesses functions of keeping the balance of calcium and phosphorus, supplying calcium, improving intestinal environment, promoting calcium absorption; it is suitable for adding into soup seasoning, wheaten food, milk products, meat products, condiments and health foods. And the microcapsule is characterized by good emulsion stability, film forming, dissolution and anti-oxidation, improved production stability and controllable release in alimentary canal.

The invention discloses a microcapsule structure containing an active oxygen shell powder composition. The microcapsule structure comprises an active oxygen shell powder core and is wrapped with a shell of a water-soluble protective layer. According to the microcapsule structure, the problems of poor water solubility and unabiding bactericidal activity of the active oxygen shell powder can be solved, the microcapsule structure can be applied to addition of food industries, and can be used as a natural non-toxic food preservative, the dosage or use of chemical preservatives is reduced, and thesafety and health of food are improved.

The invention discloses slow release urea. The urea comprises urea and acrylic resin particles, wherein urea is dispersed in the acrylic resin particles. The slow release urea can prevent the urea from being washed away by rainwater to run off, and at the same time, the slow release urea also has the effects of control of the slow release of the urea and water retention.

The invention discloses a degradable double-slow-release water-retaining fertilizer with strong water absorption and a preparation method thereof. The preparation method comprises the following steps:(1) dissolving salicylic acid and a solvent in a three-neck flask, adding adipoyl chloride and an acid-binding agent into the flask by using a constant-pressure dropping funnel, carrying out a chainextension reaction process at 140-160 DEG C, and carrying out reduced pressure distillation and vacuum drying after the reaction is completed, so as to obtain an intermediate I, (2) mixing the intermediate I with acetic anhydride, adding a catalyst, reacting at 105-110 DEG C, and carrying out cooling, crystallizing, suction filtration and washing with cold water to obtain a crude product, and recrystallizing to obtain an intermediate II, (3) making the intermediate II react with guar gum at 140-160 DEG C, and carrying out melt polycondensation to obtain the product, and (4) preparing the product into a solution, adding a borax solution to form gel, and carrying out freeze-drying and crushing. The degradable double-slow-release water-retaining fertilizer with strong water absorption can beused for double slow release of salicylic acid and boric acid, and can be used as a plant fertilizer for reducing salt damage to various plants.

The invention discloses a chitosan semi-fluid slow release gel. The chitosan semi-fluid slow release gel comprises an ingredient I and an ingredient II, wherein the ingredient I is obtained by dissolving 0.5020g / ml of prepared chitosan solution at the temperature of 4 DEG C with normal saline or distilled water as a solvent, and the ingredient II is obtained by dissolving 0.251g / ml of prepared hyaluronic acid chitosan solution at the temperature of 4 DEG C with mixed liquid formed by saturated sodium bicarbonate water solution and distilled water at the volume ratio of 1:1 as a solvent. The chitosan semi-fluid slow release gel is prepared by the steps that the ingredient I and the ingredient II are proportionally mixed at the normal temperature before usage to form a mixture in an injectable semi-fluid state, the injected position gradually solidifies and is finally cured when the temperature rises in a range from 26 DEG C to 40 DEG C, and slow drug release can be controlled. A semi-fluid gel preparation prepared by the gel can serve as a drug carrier and a scaffold for tissue engineering. The chitosan semi-fluid slow release gel is biodegradable and good in biocompatibility.

The invention discloses a special fertilizer for a primary root zone of sugarcane and a preparation process of the fertilizer. The process comprises the following steps: preparing fertilizer granules from fertilizer raw materials, wherein the fertilizer comprises the following raw materials: a nitrogen fertilizer, phosphorus pentoxide, potassium chloride and a urease inhibitor, and according to the amount of the fertilizer required by one sugarcane for an annual long term, the prepared fertilizer granule comprises the following components: 7-8 g of the nitrogen fertilizer, 2-3 g of the phosphorus pentoxide, 8-9 g of the potassium chloride and 0.2-0.5 g of the urease inhibitor; preparing a coating solution by using polyethylene resin; and spraying the coating solution to the surfaces of the fertilizer particles, so as to form a polyethylene film layer on the surfaces of the fertilizer particles, wherein the polyethylene film layer is a shell completely wrapping the fertilizer particles. The prepared fertilizer releases fertilizer nutrients to crops according to the growth needs of sugarcane, and one fertilizer can meet one growth cycle of each sugarcane plant, namely the fertilizer demand of the crops in one year, so that the utilization rate of the fertilizer can be improved, the use frequency of the fertilizer can be reduced, and the planting efficiency of the sugarcane can be improved.

The invention relates to a coated replacement-resistance type feed additive as well as preparation method and application thereof. The feed additive comprises a core material, a first capsule wall coating the core material and a second capsule wall coating the first capsule wall; the core material comprises an acidifying agent and a carrier, the acidifying agent comprises phosphoric acid, benzoic acid and zinc benzoate, and the mass ratio of phosphoric acid to benzoic acid to zinc benzoate is 1: (3-5): (1-2); the mass ratio of the acidifying agent to the carrier is 1: (0.2-0.5); the first capsule wall is made of a natural high polymer material and forms sealed or non-sealed coating on the surface of the core material; the second capsule wall is an enteric coating, and the second capsule wall forms a sealed coating on the surface of the first capsule wall. The coated replacement-resistance type feed additive can protect an active substance acidifying agent, so that the additive can act on specific organs such as intestinal tracts, the palatability and the corrosivity are improved, and the additive can be slowly released.

The invention discloses a water-based primer-topcoat coating which comprises the following components in parts by weight: 40-60 parts of a phosphate adhesive, 15-25 parts of titanium dioxide, 10-15 parts of barium sulfate, 2-5 parts of aluminum oxide, 2-5 parts of magnesium oxide, 5-15 parts of silica sol, 0.1-0.5 part of graphene oxide, 0.1-0.5 part of a thickening agent, 0.1-0.5 part of a surfactant and 30-50 parts of distilled water, by adding the silica sol, the graphene oxide and the aluminum oxide, improvement is achieved.