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Absorbable fiber reinforced multilayer film material and its prepn

A fiber-absorbing and fiber-reinforced technology, used in absorbent pads, medical science, bandages, etc., can solve the problems of unsatisfactory anti-adhesion effect and fast absorption, and achieve the effects of excellent biocompatibility, easy operation and low cost.

Inactive Publication Date: 2003-03-19
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Oxidized denatured cellulose has been clinically used as a barrier material in obstetric surgery, but it absorbs quickly, and the anti-adhesion effect is not ideal in many cases

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0023] The preparation method of absorbable fiber-reinforced multilayer film material is as follows: weave absorbable polymer fiber into a thin cloth or net of a certain size, cover, coat, spray or soak absorbable polymer solution on and under the cloth or net, Soak in a non-good polymer solvent, or dry in the air, or freeze-dry, or cross-link and dry, and sterilize to obtain a fiber-reinforced multilayer membrane material. Or weave the absorbable polymer fiber into a thin cloth of a certain size, cover, coat, spray or soak the absorbable polymer solution containing water-soluble compounds on the top and bottom of the cloth, soak or dry in the non-good solvent of the polymer Dry or freeze-dry or crosslink, soak in water to remove water-soluble compounds, and sterilize to obtain fiber-reinforced multilayer materials. Water-soluble compounds are water-soluble inorganic salts, organic salts, sugars, polyoxyethylene with a molecular weight of 200-3500, and other water-soluble poly...

Embodiment 1

[0026] It is the chitosan thread that fineness is 28tex, is woven into the chitosan cloth that the hole size is 1 millimeter, prepares 3% chitosan solution, coats a thin layer of chitosan solution on the cloth, below, after drying slightly, put The membrane was soaked in ethanol for 24 hours, dried, soaked in ibuprofen solution for 2 hours, taken out and dried, and sterilized with ethylene oxide to obtain a chitosan fiber reinforced multilayer membrane material for surgical anti-sticking.

Embodiment 2

[0028] It is the chitosan thread that fineness is 50tex, is woven into the chitosan cloth that hole size is 1 millimeter, prepares 3% chitosan solution, coats a thin layer of chitosan solution on the cloth, below, after drying slightly, put The membrane was soaked in acetone for 24 hours, dried, soaked in ibuprofen solution for 2 hours, taken out and dried, and sterilized with ethylene oxide to obtain a chitosan fiber reinforced porous membrane material for surgical anti-sticking.

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Abstract

The present invention relates to one kind of biomedical material. The three-layered material includes one middle layer is cloth, net or non-woven fabric of absorbable polymer fiber, and upper and lowr porous layers of absorbable polymer material. The absorbable polymer fiber contains chitin, chitosan, their derivative or other absorbable polymer material, and the absorbable fiber reinforced multilayer film material may contains additive. The absorbable fiber reinforced multilayer film material is prepared through weaving cloth or with polymer fiber, painting polymer solution to the upper and lower sides of the cloth or net, and post-treatment. It has high strength and is suitable for use in preventing tissue adhesion.

Description

1. Technical field: [0001] The invention relates to an absorbable fiber-reinforced multilayer membrane material for preventing tissue adhesion after operation and a preparation method thereof, belonging to the field of surgical medical materials. 2. Background technology: [0002] Postoperative adhesions are one of the most common postoperative complications. Adhesion formation is characterized by resorption of neutrophils, macrophages, and subsequently fibroblasts, with local production of various cytokines and growth factors. General adhesion development and wound healing precede adhesion formation. Anti-adhesion ingredients need to ensure that they do not affect normal wound healing and rehabilitation, and general anti-adhesion agents have limitations. [0003] Establishing a local barrier around the repaired tissue is the main way of anti-adhesion, that is, placing an inert material at the incision site of the tissue so that it can block the growth of fibrous tissue. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/42
Inventor 李新松浦跃朴章庆国王军
Owner SOUTHEAST UNIV
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