3013 results about "Gluconic acid" patented technology

The present invention provides a high-performance glucose sensor having excellent storage stability and an improved response characteristic. This sensor comprises: an electrically insulating base plate; an electrode system including at least a working electrode and a counter electrode formed on the base plate; and a reaction layer containing at least pyrrolo-quinoline quinone dependent glucose dehydrogenase, formed in contact with or in the vicinity of the electrode system, and the reaction layer contains at least one kind of additive selected from the group consisting of gluconic acid and salts thereof.

The present invention provides a method of treating glaucoma, the method comprising the step of placing a polymer in an eye of a patient, which biologically degrades over a period of time to release biodegradants, which are effective to lower the intraocular pressure of the patient, thereby treating glaucoma. Said polymer is preferably selected from the group consisting of polymers of lactic acid, glycolic acid and / or mixtures thereof. More preferably the polymer is a copolymer of lactic acid and glycolic acid, e.g. a copolymer comprising from 50 to 100% lactic acid and from 0 to 50% glycolic acid, by weight.

Compositions comprising oligosaccharide aldonic acids are useful for general care, as well as for treatment and prevention, of various cosmetic conditions and dermatological disorders, including those associated with intrinsic and / or extrinsic aging, as well as with changes or damage caused by extrinsic factors; general care, as well as treatment and prevention of diseases and conditions, of the oral, and vaginal mucosa; for general oral care, as well as treatment and prevention of oral and gum diseases; and for wound healing of the skin. Compositions comprising oligosaccharide aldonic acids may further comprise a cosmetic, pharmaceutical or other topical agent to enhance or create synergetic effects.

The present invention relates to a solid composition useful for tissue gluing, tissue sealing and haemostasis consisting essentially of a) a carrier which has at least one of the following physical properties: elasticity module in the range of 5-100 N / cm, density of 1-10 mg / cm<3>, chamber diameter of more than 0.75 mm and less than 4 mm and / or having a chamber diameter average below 3 mm and evenly distributed and fixed upon said carrier, b) solid fibrinogen, and c) solid thrombin.The carrier is a biodegradable polymer such as a polyhyaluronic acid, polyhydroxy acid, e.g. lactic acid, glucolic acid, hydroxybutanoic acid, a cellulose, gelatine or collagen, such as a collagen sponge, e.g. a collagen sponge consisting essentially of collagen type I fibres. The fibrinogen and thrombin are preferably human, purified from a natural source, or transgenic or recombinant human fibrinogen and / or thrombin. In a preferred embodiment the composition does not comprise any antifibronolytic agent such as aprotinin, epsilon-aminocaproic acid or alpha2-antiplasmin,

The invention provides methods for producing products comprising improved host cells genetically engineered to have uncoupled productive and catabolic pathways. In particular, the present invention provides host cells having a modification in nucleic acid encoding an endogenous enzymatic activity that phosphorylates D-glucose at its 6th carbon and / or a modification of nucleic acid encoding an enzymatic activity that phosphorylates D-gluconate at its 6th carbon. Such improved host cells are used for the production of products, such as, ascorbic acid intermediates. Methods for making and using the improved host cells are provided. Nucleic acid and amino acid sequences for glucokinase and gluconokinase are provided.

A dishwasher detergent containing a builder and one or more magnesium and / or zinc salt(s) of at least one monomeric and / or polymeric organic acid, excluding zinc ricinoleate, zinc abietate, and zinc oxalate. A method of inhibiting glass corrosion by treatment with one or more salts of magnesium and / or zinc with organic acids, excluding formic acid, acetic acid, gluconic acid, and oxalic acid.

Compositions for removing scale and / or inhibiting formation thereof include an alkaline agent, a primary scale inhibitor, a secondary scale inhibitor and a solvent. The primary scale inhibitor may include phosphonic acid, salts of phosphonic acids and combinations thereof. Suitable secondary scale inhibitor may include aminocarboxylic acids, salts of aminocarboxylic acids, carboxylic acids, salts of carboxylic acids, polycarboxylic acids, salts of polycarboxylic acids, gluconic acids, salts of gluconic acids, steroids, tetrapyrrols, ionophores, 2,2′-bipyridine, dimercaptopropanol, ortho-phenanthroline and combinations thereof. The compositions may be prepared as a stable concentrates that have pH values greater than or equal to 11. The compositions may also be prepared on site as a use solution. Methods of using the compositions to extend system operating times and to remove scale from and / or inhibit formation of scale on an article are also disclosed.

A skin dressing, particularly a wound dressing, comprises oxidoreductase enzyme and, optionally, peroxidase enzyme, wherein the enzyme(s) are present in hydrated condition, e.g. being present in one or more hydrated hydrogels. The dressing is used by being located on the skin of a human or animal e.g. over a wound. The oxidoreductase enzyme catalyses a reaction that produces hydrogen peroxide from an appropriate substrate, the substrate either being naturally present in body fluids and / or being supplied separately and / or being incorporated into the dressing. The currently preferred oxidoreductase enzyme is glucose oxidase. The catalyses reaction of β-D-glucose substrate to give hydrogen peroxide and gluconic acid. A mixture of oxidoreductase enzyme can undergo reaction (optionally catalysed by the peroxidase enzyme) to produce a variety of species including reactive oxygen intermediates that have antimicrobial properties and that can therefore assist in promoting wound healing.

A coating composition used for coating of a steel material and / or aluminum material comprises a corrosion inhibitor, a base resin and a curing agent. The corrosion inhibitor may be selected from cerium compounds, lanthanum compounds, molybdate salt compounds, gluconic acid derivative salts, porous base materials, triazole compounds, thiazole compounds, tetracyclines, and metal phosphate salt compounds of ascorbic acid. The base resin may include a xylene-formaldehyde-resin-modified amino-containing epoxy resins obtained by reacting an epoxy resin having an epoxy equivalent of from 180 to 2500 with a xylene formaldehyde resin and an amino-containing compound. The curing agent may be a blocked polyisocyanate compound obtained by blocking an isocyanate group of a polyisocyanate compound with a blocking agent.

Various methods are provided for the enzymatic production of glycolic acid from glycolonitrile. These methods include: 1) use of Acidovorax facilis 72W nitrilase mutants having improved nitrilase activity for converting glycolonitrile to glycolic acid, and 2) methods to improve catalyst stability and / or productivity. The methods to improve catalyst stability / productivity include use of reaction stabilizers, running the reactions under substantially oxygen free conditions, and controlling the concentration of substrate in the reaction mixture.

It has been discovered that metals and / or amines can be removed or transferred from a hydrocarbon phase to a water phase in an emulsion breaking process by using a composition that contains water-soluble hydroxyacids. Suitable water-soluble hydroxyacids include, but are not necessarily limited to glycolic acid, gluconic acid, C2-C4 alpha-hydroxy acids, poly-hydroxy carboxylic acids, thioglycolic acid, chloroacetic acid, polymeric forms of the above hydroxyacids, poly-glycolic esters, glycolate ethers, and ammonium salt and alkali metal salts of these hydroxyacids, and mixtures thereof. The composition may also include at least one mineral acid to reduce the pH of the desalter wash water. A solvent may be optionally included in the composition. The invention permits transfer of metals and / or amines into the aqueous phase with little or no hydrocarbon phase undercarry into the aqueous phase. The composition is particularly useful in treating crude oil emulsions, and in removing calcium and other metals therefrom.

The present invention provides a gel beverage composition for comprehensive nutritional supplementation, having balanced nutrients, refreshing taste, a low pH, a soft gel form suitable for drinking / eating and the ability to retain its gel form for a long period of time. The composition is a gel which has a pH ranging from 3-4 and contains 5-20% by weight of saccharide, 0.1-5% by weight of fat, 2.5-6% by weight of protein material which does not coagulate at pH 3-4, 0.2-3% by weight of citric acid, 0.2-1.5% by weight of at least one acid component selected from the group consisting of ascorbic acid, tartaric acid, succinic acid, malic acid, gluconic acid, phosphoric acid, phytic acid, lactic acid and trisodium citrate, 0.01-0.5% by weight of an emulsifying agent, 0.1-1% by weight of agar and 65-90% by weight of water.

The invention relates to high-dietary fiber five-cereal puffing powder and a preparation method, and belongs to the field of food processing. The five-cereal puffing powder comprises the following raw materials: coarse rice powder, wheat meal, oatmeal, millet meal, glutinous corn meal, soybean meal, wheat bran meal, calcium lactate, ferrous gluconate, zinc gluconate, vitamin B1, vitamin B2 and vitamin B6. A method for processing the five-cereal puffing powder comprises the following steps of: screening coarse cereals, grinding, milling, sieving with an 80-mesh sieve, mixing uniformly in a ratio, adjusting the moisture of materials, balancing the moisture, extruding and puffing by using double screws, drying, crushing, and sieving with a 100-mesh sieve, enhancing mineral elements and the vitamins. The high-dietary fiber five-cereal puffing powder has the characteristics that the puffing powder is prepared from natural grain coarse cereals, emulsifying agents and sweeteners are not added, the mineral elements and the vitamins are enhanced, the content of dietary fibers reaches the specified standard of national high-dietary fiber foods, and the puffing powder can be eaten only by being infused by boiling water, so that the high-dietary fiber five-cereal puffing powder is an ideal nutritional and convenient food which is suitable to be eaten by middle and old-aged people.

The invention provides a composite low-phosphorus corrosion and scale inhibitor and application thereof. The composite low-phosphorus corrosion and scale inhibitor is prepared from a corrosion and scale inhibitor A and a corrosion and scale inhibitor B, wherein the corrosion and scale inhibitor A is prepared from 20-40 parts of polyepoxysuccinic acid (PESA), 20-40 parts of sodium gluconate and 20-60 parts of water; and the corrosion and scale inhibitor B is prepared from 10-25 parts of hydroxypropyl methacrylate (HPMA), 10-25 parts of acrylic acid / 2-acrylamido-2-methylacrylsulfonic acid copolymer (AA / AMPS), 5-10 parts of 2-phosphonobutyl-1,2,4-tricarboxylic acid (PBTCA), 10-25 parts of zinc salt, 1-2 parts of fluorescent tracer and 13-64 parts of water. The technical scheme is as follows: the corrosion and scale inhibitor A and the corrosion and scale inhibitor B in a weight ratio of 1:2 are compounded with water. The composite low-phosphorus corrosion and scale inhibitor has excellent corrosion and scale inhibition effects, and thus, the phosphorus content in the product is low, thereby reducing the phosphorus discharge and having favorable environmental protection performance.

The invention provides a non-naturally occurring microbial organism having a muconate pathway having at least one exogenous nucleic acid encoding a muconate pathway enzyme expressed in a sufficient amount to produce muconate. The muconate pathway including an enzyme selected from the group consisting of a beta-ketothiolase, a beta-ketoadipyl-CoA hydrolase, a beta-ketoadipyl-CoA transferase, a beta-ketoadipyl-CoA ligase, a 2-fumarylacetate reductase, a 2-fumarylacetate dehydrogenase, a trans-3-hydroxy-4-hexendioate dehydratase, a 2-fumarylacetate aminotransferase, a 2-fumarylacetate aminating oxidoreductase, a trans-3-amino-4-hexenoate deaminase, a beta-ketoadipate enol-lactone hydrolase, a muconolactone isomerase, a muconate cycloisomerase, a beta-ketoadipyl-CoA dehydrogenase, a 3-hydroxyadipyl-CoA dehydratase, a 2,3-dehydroadipyl-CoA transferase, a 2,3-dehydroadipyl-CoA hydrolase, a 2,3-dehydroadipyl-CoA ligase, a muconate reductase, a 2-maleylacetate reductase, a 2-maleylacetate dehydrogenase, a cis-3-hydroxy-4-hexendioate dehydratase, a 2-maleylacetate aminoatransferase, a 2-maleylacetate aminating oxidoreductase, a cis-3-amino-4-hexendioate deaminase, and a muconate cis / trans isomerase. Other muconate pathway enzymes also are provided. Additionally provided are methods of producing muconate.

A composition for restoring and maintaining gastrointestinal health comprises 40-60% by weight of an immunoglobulin composition comprising concentrated immunologically active immunoglobulins and 40-60% by weight of soluble dietary fiber selected from inulin, fructo-oligosaccharides, pectin, guar gum, and mixtures thereof. The immunoglobulin and fiber-containing composition can optionally contain one or more of a beneficial human intestinal microorganism, components of a non-immune natural defense system, an iron-sequestering molecule, and gluconic acid. Preferred beneficial human intestinal microorganisms include lactobacilli and bifidobacteria. The immunologically active immunoglobulins are preferably purified from bovine milk, milk products, or whey. Methods of use are also described.

Compositions comprising oligosaccharide aldonic acids are useful for general care, as well as for treatment and prevention, of various cosmetic conditions and dermatological disorders, including those associated with intrinsic and / or extrinsic aging, as well as with changes or damage caused by extrinsic factors; general care, as well as treatment and prevention of diseases and conditions, of the oral, and vaginal mucosa; for general oral care, as well as treatment and prevention of oral and gum diseases; and for wound healing of the skin. Compositions comprising oligosaccharide aldonic acids may further comprise a cosmetic, pharmaceutical or other topical agent to enhance or create synergetic effects.

The invention relates to the compound fertilizer field, and particularly relates to a high-quality strawberry planting dedicated slow-release compound fertilizer. The fertilizer is prepared from the following raw materials in parts by weight: 10-15 parts of a 1250-2000 mesh diatomite, 4-5 parts of borax, 2-3 parts of ammonium molybdate heptahydrate, 10-12 parts of sodium humate, 20-25 parts of urea, 18-22 parts of potassium nitrate, 25-28 parts of organic compost, 2-4 parts of fish meal, 1-3 parts of sesame leaves, 8-10 parts of alfalfa meal, 15-18 parts of corn distiller grains, 2-4 parts of brine, 8-10 parts of an erythromycin fungi residue, 1-2 parts of an EM microbial agent, 4-6 parts of a fern root residue, 1-3 parts of nano silver, 1-2 parts of a semen ginkgo powder, 4-6 parts of 1,6-hexanediol diacrylate, 10-12 parts of an acrylic resin dispersion liquid, 1-2 parts of isocyanate, 1-2 parts of calcium stearoyl lactate, 2-4 parts of zinc gluconate, 6-8 parts of table vinegar, and 4-5 parts of an auxiliary agent. The compound fertilizer has multiple nutrients, is low in production cost and good in slow-release effect, allows double coating to be formed on the nutrients by utilizing diatomite and a coating agent in the process, also contains various trace elements, has no toxicity and no pollution, and is excellent in quality of planted strawberry and obvious in yield and income increasing effects.

This invention relates to a process for the preparation of aldonic acids (in particular gluconic acid) by oxidation of aldoses with oxygen or with a gas containing oxygen, in the presence of supported bimetallic catalysts based on gold and platinum.

The invention discloses a preparation method and a use of poly(lactic-co-glycolic acid) (PLGA) microspheres as nucleic acid vaccine vectors. A result of an animal immunization experiment shows that the PLGA microspheres can be utilized as gene vaccine vectors. Principles of the PLGA microspheres comprise that 1, the PLGA microspheres have core-shell structures; surface polymers comprise polymine, PLGA, glucose, chitosan, polylysine, FeCl3 and FeCl2; and through static electricity, dewatering interaction and hydrogen bond-nucleic acid vaccine interaction, a nucleic acid vaccine is concentrated to form a compact nucleic acid vaccine so that nucleic acid vaccine degradation is reduced in vivo; 2, the PLGA microspheres have magnetism and thus after immunization injection, in a strong magnetic field, the distribution of the PLGA microspheres in muscular tissue is improved and the defect of limited contact between the PLGA microspheres and target cells is overcome; and 3, through long-term strong magnetic field induction, a magnetic PLGA microsphere / nucleic acid vaccine complex can enter into the skin; and because of rich antigen presenting cells in the skin, a strong and fast immune response can be induced.

The invention adopts a melt polycondensation method. A few of monomers of C2-5 aliphatic dibasic alcohol, diethylene glycol, polyglycol, fumaric acid, maleic anhydride, lactic acid, glycolic acid, ethanolamine, C2 to C12 aliphatic diamine, glutamic acid, lysine, glycine, etc. are taken as basic materials to be synthesized to obtain non toxic unsaturated polyester-amide resin with adjustable degradation rate and lower cost; wherein, the partial fumaric acid or maleic anhydride can be replaced with phthalic anhydride, isophthalic acid, or adipic acid. The resin yearns for being used as matrix resin of medical bone internal fixation material, tissue engineering scaffold material, bone tissue temporary substitutes, environmental protection type bonding agent, environmental protection type fiberglass reinforced plastics, environmental protection type coating material, disposable tableware, packing material, shopping bags, disposable bags, drug coating or capsule, drug delivery (controlled-release) material, agricultural mulching films, etc., and can be recovered to be utilized.

A dishwasher detergent containing a builder and one or more magnesium and / or zinc salt(s) of at least one monomeric and / or polymeric organic acid, excluding zinc ricinoleate, zinc abietate, and zinc oxalate. A method of inhibiting glass corrosion by treatment with one or more salts of magnesium and / or zinc with organic acids, excluding formic acid, acetic acid, gluconic acid, and oxalic acid.

The invention discloses a phosphate-free environment-friendly cleaning agent which has non-toxic, innocuous, noncombustible, non-explosive, non-volatile, nonflammable, inodorous and phosphate-free. The cleaning agent mainly comprises the following raw material formulations in portion by weight: group A: 3 portions of sodium citrate, 2 portions of sodium gluconate, 4 portions of sodium hydroxide, 3 portions of sodium silicate, and 1 portion of sodium carbonate; group B: 3 portions of fatty alcohol-polyoxyethylene ether-AEO9, 4 portions of octylphenol-polyethoxylate OP-10, and 3 portions of triethanolamine; and group C, 60 to 80 portions of purified water.

The invention relates to a skin-whitening chloasma-reducing skin-brightening composition comprising raw materials of, by weight: 0.5 to 20 parts of nicotinamide, 0.1 to 15 parts of L-ascorbic acid 2-glucoside, 0.1 to 10 parts of an yeast extract, 0.05 to 10 parts of sodium lactate / sodium gluconate, 0.01 to 3.5 parts of sodium hydroxide, and 10 to 60 parts of water. With the composition provided by the invention, appearing and transferring of skin melanin can be inhibited or prevented from various perspectives; skin collagen protein synthesizing can be promoted, skin nutrients can be supplemented, such that skin aging can be retarded; and whitening effects can be achieved rapidly. Whitening active components are likely to be decomposed, oxidized, and discolored. With the composition, the problems can be solved; influences of lights and heat on the effective components are reduced. The product produced by the invention is safer than other whitening agents. With the product produced by the invention, nutrients required by skins can be provided. With a sustained-releasing technology, the whitening effect is more durable.

A prophylactic treatment for the human malady clinically described as migraine headache comprising daily administration in unit dosage form of a first formulation which comprises a major amount of bioactive peptides and a minor amount of probiotics. Concurrently, daily administration in dosage form of a second formulation of a major amount of active components like malic acid, sylibum marianum, acetyl-L-cysteine, copper chelate, zinc gluconate, aspartate and bromelain. A minor amount of plant derivatives excipients comprise the balance of the second formulation. Preferably, these plant derivatives include beet root, powder, watercress, celery, dandelion, capsicum and artichoke extract.

The invention provides a preparation of a corrosion and scale inhibitor used for high alkaline high chlorine circulating cooling water which is prepared according to the following parts by weight: 23-25 parts of PESA, 23-25 parts of 2-phosphonic acid butane-1, 2, 4-tricarboxylic acid, 12-15 parts of corrosion and scale inhibitor, 10-15 parts of sodium gluconate, 5-8 parts of alkyl epoxy carboxylate, 2-3 parts of BTA, and 10-20 parts of pure water. The preparation comprises the following steps: adding industrial phosphoric acid of 400-420kg into a reaction kettle for stirring, adding triethanolamine of 140-160kg slowly within 30-35min, stirring for 50-60min, keeping the temperature at 40-80 DEG C, adding pure water of 385-400kg and stirring for 20-30min; adding zinc oxide of 45-55kg under stirring, stirring for 90-120min, and keeping the temperature at 40-80 DEG C to obtain the corrosion inhibition potentiating agent, adding PESA into the 2-phosphonic acid butane-1, 2, 4-tricarboxylic acid to mix with the solution of the corrosion inhibition potentiating agent, sequentially adding alkyl epoxy carboxylate, pure water and sodium gluconate to stir for 30-40min, keeping the temperature at 20-35 DEG C, then adding BTA, stirring for 30-60 min, and keeping the temperature at 20-35 DEG C to obtain the composite corrosion and scale inhibitor.

A method for combating unwanted conditions downstream of the mouth with adhering troches. A method to treat or reduce replication of a virus in throat tissues by releasing an anti-viral from an adhering disc. A method to treat sore throat with time release of Glycyrrhiza extract or collagen from an adhering disc. A method to treat sore throat with topically applied cobalamin. An adhering troche that releases antacid, alginate, bismuth subsalicylate, soluble zinc, such as zinc gluconate, bioactive vitamin B12 (methylcobalamin), antibiotic, or anti-viral. A method to combat bacterial effects downstream of the mouth with topically applied xylitol.

The invention provides bacterial cellulose (BC) producing bacteria and a method for preparing the bacterial cellulose by using the bacterial strain. The bacterial strain is a selected gluconic acid acetobacter xylinum GD-BC-1 with an accession number of CCTCC M 208149. The method is to use the bacterial strain as a fermentation bacterial strain and use glucose as a main fermentation material for fermentation so as to obtain the BC. The preparation method comprises the following steps of: activating a slant bacterial strain, liquid-activating the slant bacterial strain, inoculating the liquid-activated slant bacterial strain in a fermentation culture medium to perform dynamic or static fermentation and extracting products of BC from the fermentation solution. The preparation method uses the bacterial strain of gluconic acid acetobacter xylinum GD-BC-1 with the accession number of CCTCC M 208149 for fermentation so as to produce the BC. The BC can be produced through dynamic or static fermentation in a conical flask with glucose as the main fermentation material, and the yield is high and different methods can be used in different production environment to produce BC.

The invention provides a liquid cement grinding additive, which comprises the following components in percentage by weight: 10 to 20 percent of tetrahydroxyethyl-ethylenediamine, 10 to 20 percent of ethoxyl-diethylenetriamine, 10 to 15 percent of diethylene glycol, 5 to 10 percent of polyethylene glycol, 2 to 5 percent of sodium tripolyphosphate, 3 to 5 percent of calcium lignosulphonate, 0 to 10 percent of tri-isopropanolamine, 0 to 8 percent of sodium gluconate, and the balance of water, wherein the molecular weight of the polyethylene glycol is between 200 and 400. As a preferred scheme of the invention, the content of the tri-isopropanolamine is between 5 and 10 percent, and the content of the sodium gluconate is between 5 and 8 percent. A cement and concrete admixture using the liquid cement grinding additive has good adaptability, can significantly improve the grinding efficiency of a grinding machine and improve the strengths of the cement in an early period and a later period by 2 to 4 MPa, or can reduce the clinker dosage by 4 to 8 percent and increase the adding volume of a mixed material by 4 to 8 percent in the cement under a condition of keeping the same cement strength grade.