54 results about "Idebenone" patented technology

Use of idebenone for the preparation of a medicament for transmucosal administration.

A method for promoting weight management in a mammal is provided, comprising administering to the mammal a composition comprising at least one weight loss agent and at least one mitochondria enhancingagent. The weight loss agent may be selected from the group consisting of psyllium, guar gum, capsaicin, chitosan, caffeine, garcinia cambogia, Pinus densiflora, capsaicin, yohimbre, hoodia, glucomannan, African mango, guarana, pyruvate, carnitine, beta-glucan, fucoxanthin, raspberry ketone, white kidney bean, kola nut, chromium, ginseng, psyllium, St. John's wort, dandelion, hydroxycitric acid,conjugated linoleic acid, green tea, black tea, green coffee beans extract, forskolin and bitter orange. The mitochondria enhancing agent may be selected from the group consisting of beetroot extract,nitrate, idebenone, nicotinamide riboside, elamepratide, vitamin C, vitamin D, vitamin E, thiamine, riboflavin, magnesium, calcium, phosphate, phospholipid, creatine, pyruvate, coenzyme Q10, NADH, nicotinic acid, L-camitine, dicholoracetate, curcumin, schisandrin and resveratrol. Compositions for weight management are also provided.

The invention describes the use of an injectable form of Idebenone to induce protect from neuronal damage, improve recovery after brain trauma; stroke, intoxication, neurodegenerative diseases, memory loss or neuropathology associated with neuroinflammation or infection damage and to restore cognitive function, suppress disorientation, alcoholic and drug abuse associated syndromes and other signs of neuronal damage.

The present invention in one embodiment provides a compound of Formula I:(I), or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula I are as defined in the specification.

The invention discloses an idebenone nanometer lipid carrier transdermal absorption preparation and a preparation method thereof. The preparation method comprises the following steps: mixing idebenone, solid lipid materials, liquid lipid materials and a surface active agent 1 uniformly, and heating until the mixture is turned into a lipid phase; mixing a surface active agent 2 with ultrapure water uniformly so that the mixture is turned into a water phase; adding the lipid phase into the water phase slowly under the condition of keeping the temperature of the lipid phase and the water phase consistent while stirring; homogenizing rapidly, cutting, carrying out primary emulsification, carrying out ultrasonication again, and cooling down, so that a lipid carrier of a nanometer structure loading idebenone is prepared; and adding pharmaceutically acceptable auxiliary materials, so that the idebenone nanometer lipid carrier transdermal absorption preparation is prepared. The particle diameter of the idebenone nanometer lipid carrier transdermal absorption preparation provided by the invention is 40.2-110.2nm, the entrapment rate is 80.5%-99.1%, the zeta potential is minus 25.5-minus 34.4mV, the morphology is stable, an organic solvent is not contained, the idebenone nanometer lipid carrier transdermal absorption preparation has good compatibility with skin and has no irritation, the first pass effect is avoided, and the bioavailability is improved.

Use of idebenone for the preparation of a medicament for the treating of a muscular dystrophy in particular for treating and / or preventing weakness and / or loss of skeletal muscle tissue and / or cardiomyopathy associated with a muscular dystrophy.

The invention relates to a preparation method for idebenone, comprising the following steps: (1), 3,4,5-trimethoxy-toluene has friedel-crafts reaction with 10-acetoxy-decane chloride or 10-acetoxy-decanoyl- bromine to generate 6-(10-acetoxy-1-oxo-decane yl)-2,3-dimethoxy-5-methyl phenol; (2), the 6-(10-acetoxy-1-oxo-decane yl)-2,3-dimethoxy-5-methyl phenol obtained in the step (1) is reacted withhydrogen under the joint effect of palladium-carbon catalyst and dehydrating agent DCC to generate 6-(10-acetoxy-decyl)-2,3-dimethoxy-5-methyl phenol; (3), the6-(10-acetoxy-decyl)-2,3-dimethoxy-5-methyl phenol prepares 6-(10-hydroxy decyl) -2,3-dimethoxy-5-methyl phenol through hydrolysis; (4), the 6-(10-hydroxy decyl) -2,3-dimethoxy-5-methyl phenol has oxidation reaction with an oxygen-supply body under the effect of catalytic oxidizer Cu (Salen) so as to generate the idebenone. The preparation method has low cost and high yield, which is suitable for large-scale industrial idebenone production.