539 results about "Topical preparation" patented technology

A method for reducing an occurrence of hyperpigmentation in human skin includes applying to the skin a topical preparation including an amount of an agent effective to reduce an occurrence of hyperpigmentation in human skin. The agent includes idebenone or a derivative of idebenone.

The present invention discloses a topical scalp and transdermal preparation with excellent penetration to the skin and follicle, containing a [γ-hydroxy-N-methyl-L-leucine⁴] cylosporin derivative which is a non-immunosuppressive component with hair growth stimulating ability. The topical scalp and transdermal preparation is prepared by incorporating the cyclosporin derivative into a liposome, microcapsule, micro-sphere, composite particle or emulsion, capable of being employed as a hair growth stimulating agent and applied for the prevention of hair loss.

The invention discloses a medicinal composition for treating gynecological inflammation, and belongs to the field of Chinese medicament. The medicinal composition consists of collagen and/or Chinese medicaments for releasing toxin and sterilizing such as collagen and lizardtail, glabrous greenbrier rhizome, Vietnamese sophora root and the like which are prepared into a plurality of dosage forms bycombining the prior art, and is mainly used for treating vaginitis, pelvic inflammation, urethritis and cervicitis diseases. The technical scheme overcomes the defects that the prior externally-applied preparations such as lotion, gel, suppository, ointment and the like have extremely slow response, longer disease course, repeated outbreak and the like, and creatively combines and applies the collagen and the Chinese medicament, can accelerate the healing of ulcer and erosion faces caused by the inflammation, and can greatly shorten the required time for tissue repair.

Since treatment effects of conventional external preparations were not satisfactory, it is aimed to provide a novel external preparation that is excellent in drug permeability to nail, capable of fully exhibiting effects of an antifungal drug, and effective for treatments of diseases such as nail mycosis and nail candidiasis, particularly, treatments for nail tinea. The external preparation of this invention is a pharmaceutical composition for nail characterized by containing an antifungal drug, alkylpyrrolidone or a derivative thereof, and a crosslinking hydrogel.

Disclosed herein are topical formulations for treating depression with S adenosyl methionine (SAM-e) The topical formulations contain at least 35% wt/wt of SAM-e partially dissolved in aqueous and lipophilic phases of an emulsion and the emulsion is stable from separation of phases for a period of at least 30 days despite the high concentration of SAM-e. Also provided are methods for making such compositions and methods of treating depression using the same.

The invention discloses a new external Chinese medicinal composition with functions of blackening hair and dressing hair and a preparation method thereof. The Chinese medicinal composition mainly comprises the following raw material medicaments: tuber fleeceflower root, ginseng, Chinese angelica, oriental arborvitae carbon, Szechuan lovage rhizome, incised notopterygium rhizome, fineleaf schizonepeta herb, cassia twig, Manchurian wildginger, mint, kudzuvine root, chrysanthemum, baical skullcap root, lightyellow sophora root, weeping forsythia, red paeony root, white paeony root, divaricate saposhnikovia root, storax, dahurian angelica root, mugwort leaf, Chinese honeylocust fruit, prepared rehmannia rhizome, clove, pseudoginseng root, root of red-rooted salvia, black sesame and yerbadetajo herb. The Chinese medicinal composition of the invention can be prepared into any external preparation by a conventional Chinese medicinal preparation method. The Chinese medicinal composition can remarkably improve qi and blood circulation, expel wind and cold pathogens, dredge qi and blood, activate blood circulation to dissipate blood stasis, expel head wind, blacken hair, dress hair and improve the symptoms such as white hair, gray hair, brown hair, easily broken hair, hair loss and the like, and has extract clinical effect, remarkable curative effect and quick response. The Chinese medicinal composition is combined by adopting the medicaments prescribed by the national formulary and an external therapy method is adopted, so the Chinese medicinal composition has no stimulation on the skin or dependency and has the advantages of low expense, no toxic or side effect and the like.

An improved method and preparation for the treatment of acne and hirsutism comprises topically applying an effective amount of a saw palmetto berry extract, and preferably one or more low irritability constituents that enhance penetration of the extract into hair follicle sebaceous glands. The low irritability penetration aid may be selected from the group consisting of adapalene, tretinoin, tretinoin gel microsponges, retinaldehyde, retinol, tazarotene, beta hydroxy acids (salicylic acid), azelaic acid, and alpha hydroxy acids (glycolic acid) as well as polyolprepolymer-2.

An improved method and preparation for the treatment of acne and hirsutism comprises topically applying an effective amount of a saw palmetto berry extract, in combination with two classes of low irritability penetrating agents that enhance penetration of the extract into hair follicles and sebaceous glands. The low irritability penetration agents are selected from the group (A) comedolytics consisting of adapalene, tretinoin, tretinoin gel microsponges, retinaldehyde, retinol, and tazarotene, and (B) keratinolytics consisting of the beta hydroxy acid, salicylic acid, and the alpha hydroxy acid, glycolic acid. Polyolprepolymer-2 may be incorporated into the preparation as well.

The invention is a cooling cosmetic or medical topical preparation, comprising one or more substances having a melting point or melting interval between 28° C. and 40° C. and a positive melting enthalpy, wherein the one or more substances are present in the preparation in the solid state.

Disclosed is a topical preparation for the treatment of topical itch in humans and animals. The said composition consists of Opuntia, Propolis, Stearic Acid, Beeswax, Vegetable Oil and β-sitosterol. Itch includes scratch reaction itch, anal itch, or irritant itch due to plants (e.g., poison ivy), insect bite, sunburn, chemical itch, eczema, pruritis dermatitis, diabetic skin itch, aging skin itch, foot-itch, chickenpox, jock itch, hives, itch of healing burns and wounds, dry winter skin itch, and stress-related scalp itch, etc

An external preparation containing the following components (A), (B), and (C):

• • (A) a non-steroidal analgesic/anti-inflammatory agent,
  • (B) a polyhydric alcohol, and
  • (C) a polyoxyalkylene alkyl ether and/or a polyoxyalkylene alkenyl ether. The external preparation of the present invention has improved the drug efficacy of a non-steroidal analgesic/anti-inflammatory agent, and can be effective at a low concentration. The external preparation of the present invention also has excellent appearance.

A topical sustained release delivery system for delivery of antifungal agents to the finger or toenails achieving high penetration through the nails by combining the antifungal agent with a keratolytic agent and a humectant. The pharmaceutical sustained release topical preparation is provided in a varnish or spray form for treating the nail and surrounding tissues, where the active ingredient is an antifungal agent, a keratolytic agent, or preferably a combination of an antifungal and a keratolytic agent. The composition may further comprise an antibacterial, an antiviral, an antipsoriatic agents, or combinations thereof.

The invention relates to an external preparation for skin moistening. The preparation is formed by an effective component and medically acceptable auxiliary materials, and is characterized in that the effective component is dendrobium officinale polysaccharide with the molecular weight of 85-90 KDa. The external preparation for skin moistening disclosed by the invention can increase the expression quantity of a skin aquaporins-3 gene so as to accelerate further multiplication of malpighian cells and obviously improve a skin water retention effect.

An external preparation composition used for preventing or treating symptoms or diseases related to dermatopathy caused by dryness, UV rays and aging such as wrinkles and sags of the skin, pigmentation of the skin, skin roughness and coarse texture and skin diseases such as psoriasis, lichen, ichthyosis, keratosis, Darier's disease, pustulosis, acne, eczema and atopic dermatitis. The external preparation composition comprises at least one of acyl glucosamine derivatives represented by the following Formula (I):

• • wherein R₁, R₂, R₃, R₄ and R₅ are defined; and X is any one of groups represented by the following Formulas (A) to (C):

wherein Y, n and R₆ are also defined.

Disclosed herein is a preparation for topically delivering and localizing therapeutic agents, comprising: a vasoconstrictor for retarding vascular dispersion of a therapeutic agent; and a penetration enhancer for facilitating penetration of the vasoconstrictor and the therapeutic agent through a patient's skin. Further disclosed is an associated method of topically delivering and localizing therapeutic agents, comprising the steps of: using a vasoconstrictor for retarding vascular dispersion of a therapeutic agent; in combination with using a penetration enhancer for facilitating penetration of the vasoconstrictor and the therapeutic agent through a patient's skin. Also disclosed are various courses of treatment, which comprise applying the various disclosed combinations of agents to the patient's skin.

It is intended to provide an antiinflammatory and analgesic preparation for external use whereby side effects of a nonsteroidal antiinflammatory and analgesic drug on the skin can be regulated, the nonsteroidal antiinflammatory and analgesic drug can be prevented from degeneration with time due to a dibenzoylmethane derivative contained as an UV absorbent therein, the dibenzoylmethane derivative can be prevented from crystallization and sedimentation due to an oily phase component contained therein, and the inherent effects of the nonsteroidal anti-inflammatory and analgesic drug can be fully exerted without showing skin irritation caused by the oily phase component, an emulsifier and a thickener. The above problem can be solved by providing an antiinflammatory and analgesic preparation for external use which comprises a base for external use containing an oily phase component, a nonsteroidal antiinflammatory and analgesic drug and a dibenzoylmethane derivative and in which the total amount of fatty acid esters in the oily phase component is at least thrice as much as the content of the dibenzoylmethane derivative.

The invention relates to an external preparation made from Chinese herbal medicines, specifically to a film-spraying agent for treating acute soft tissue injuries. 1000ml of the film-spraying agent in the invention is composed of the following raw materials: a Chinese herbal extract extracted from 20-60g of rheum officinale, 20-60g of Cacumen Platycladi, 10-30g of Cortex Phellodendri amurensis, 10-30g of Herba Lycopi and 10-30g of mint by ethanol, 2-6g of borneol, 0.4-1.2g of menthol, 2-6g of chlorobutanol, 30-60g of polyvinylpyrrolidone, 1-8g of hydroxypropyl methyl cellulose, and the rest ethanol water with a volume concentration of 30-40%. During application, the film-spraying agent of the invention is directly sprayed on the injured part and can form a film in 8 minutes. With good anti-inflammation, pain easing, stasis removing, acute soft tissue injury improving and microcirculation improving, as well as antibacterium effects, the film-spraying agent provided in the invention has an obvious effect in treating acute soft tissue injuries such as sprains, contusions and other local injuries, and redness, swelling, heat, pain, wound surface infection, as well as other aspects.

Novel compositions for hair loss prevention and/or hair growth promotion comprising at least active agent preferably derived from natural source such as from the plant Vernonia sp., either alone or in combination with other active agent(s) and optionally one or more excipient(s) are provided. The process for the extraction of hair growth promoting agent and preparation of compositions comprising such active agent are also described. The novel composition is preferably in the form of an oral or topical preparation such as tablet, capsule, liquid solution or suspension, cream, gel, lotion or spray and is useful against hair disease(s)/disorder(s) and/or other associated disorders particularly in the management of testosterone induced androgenic alopecia.

Compositions and methods, including novel homogeneous microparticulate suspensions, are described for treating acute wounds, chronic wounds and/or a wound or epithelial tissue surface that contains bacterial biofilm, including unexpected synergy between bismuth-thiol (BT) compounds and certain antibiotics, to provide topical formulations including antiseptic formulations, for management and promotion of wound healing and in particular infected wounds. Previously unpredicted antibacterial properties and anti-biofilm properties of disclosed BT compounds and BT compound-plus-antibiotic combinations are also described, including preferential efficacies of certain such compositions for treating gram-positive bacterial infections, and distinct preferential efficacies of certain such compositions for treating gram-negative bacterial infections.