The invention relates to a formula of soles of PU-simulated foaming sneakers through injection, which comprises the following raw materials in percentage by mass: 40 percent of 21 percent ethylene-vinyl acetate copolymer (EVA 7360), 16.7 percent of styrene butadiene copolymer SBBSJT-83, 12.5 percent of ethylene octylene copolymer POE8130, 8.3 percent of ethylene-propylene-diene copolymer 3745P, 65.9 percent of wear-resisting agent A-18, 8.3 percent of talcpowder, 0.25 percent of stearic acid, 0.42 percent of zinc stearate, 0.9 percent of zinc oxide, 0.08 percent of bridging auxiliary agent ET-102, 0.75 percent of bridging agent DCP, 1.7 percent of high-temperature foaming agent AC-6000H, 2.5 percent of titanium white powder R-103 and 1.7 percent of master batch. The preparation method comprises the steps of banburying, mixing, granulation, injection molding, physical property tests and the like. Thus, in the research and development and application, the PU-simulated foaming soles not only have the physical and chemical properties of no crease marks, high elasticity, low compression and wear resistance of PU soles, and but also have the advantages of low production cost, light specific gravity, good limited-slip properties, no hydrolysis and long service life.