The invention belongs to the technical field of skin care oil medicine, in particular to skin care oil medicine containing peony oil and a preparation method thereof. The skin care oil medicine provided by the invention comprises the following components in parts by weight: main ingredients: peony seed oil, caprylic / capric triglyceride, cyclopentasiloxane and 1, 2 - butyl glycol 1-12, wherein the peony oil is peony seed oil or peony essence oil or the mixture of peony seed oil and peony essence oil; auxiliary ingredients: isostearic acid, butylated hydroxytoluene, avocado oil, simmondsia chinensis seed oil, meadowfoam seed oil and macadamia ternifolia seed oil; the skin care oil medicine containing peony oil prepared by the method provided by the invention can remarkably improve of the skin epidermis cell cycle function, promote the microcirculation of the blood capillary of the dermal skin effect, inhibit lipid peroxidation, improve metabolism, delay skin aging process, is provided with anti-wrinkle, moisturizing and whiting effect, people feels smooth and comfortable after the skin care oil medicine is used on the skin, and the skin care oil medicine containing peony oil is provided with better effect to chloasma, aging skin wrinkles, skin cutin hardening peeling and skin chap.