The invention relates to the technical field of the cleaning of daily necessities, and discloses an air conditioner cleaning agent and a manufacturing method thereof. The air conditioner cleaning agent is characterized by comprising the following raw materials in percentage by weight: 1-5% of a surfactant, 5-15% of an environment-friendly organic solvent, 1-5% of a co-solvent, 2-7% of cyclodextrin, 0.1-2% of a sterilizing agent, 0.1-2% of a corrosion inhibitor, 0.1-0.5% of sodium pyrophosphate, 1-5% of sodium carbonate, 1-5% of sodium bicarbonate, 1-5% of sodium chloride, 0.5-1% of ethylene diamine tetraacetic acid, 0.1-0.5% of essence and the balance of deionized water. Compared with the prior art, the air conditioner cleaning agent disclosed by the invention has the advantages that (1) the co-solvent is added in the cleaning agent to increase the solubility of the raw materials in the solvent; cyclodextrin is added in the cleaning agent to reduce the irritations of the surfactant to the skin, and can be used for forming a stable inclusion compound with pollutants, thus reducing the environment pollution; and (2) the cleaning agent has good cleaning performances, can be used for cleaning the dirt completely, is low in cost and small in environment pollution, does not damage the air conditioner, and is convenient in use.