282 results about "Hydroxycinnamic acid" patented technology

This invention provides methods and devices for spatially separating at least first and second components in a sample which in one exemplary embodiment comprises introducing the first and second components into a first microfluidic channel of a microfluidic device in a carrier fluid comprising a spacer electrolyte solution and stacking the first and second components by isotachophoresis between a leading electrolyte solution and a trailing electrolyte solution, wherein the spacer electrolyte solution comprises ions which have an intermediate mobility in an electric field between the mobility of the ions present in the leading and trailing electrolyte solutions and wherein the spacer electrolyte solution comprises at least one of the following spacer ions MOPS, MES, Nonanoic acid, D-Glucuronic acid, Acetylsalicyclic acid, 4-Ethoxybenzoic acid, Glutaric acid, 3-Phenylpropionic acid, Phenoxyacetic acid, Cysteine, hippuric acid, p-hydroxyphenylacetic acid, isopropylmalonic acid, itaconic acid, citraconic acid, 3,5-dimethylbenzoic acid, 2,3-dimethylbenzoic acid, p-hydroxycinnamic acid, and 5-br-2,4-dihydroxybenzoic acid, and wherein the first component comprises a DNA-antibody conjugate and the second component comprises a complex of the DNA-antibody conjugate and an analyte.

The present invention provides several methods for biological production of para-hydroxycinnamic acid (PHCA). The invention is also directed to the discovery of new fungi and bacteria that possess the ability to convert cinnamate to PHCA. The invention relates to developing of a new biocatalyst for conversion of glucose to PHCA by incorporation of the wild type PAL from the yeast Rhodotorula glutinis into E. coli underlining the ability of the wildtype PAL to convert tyrosine to PHCA. The invention is also directed to developing a new biocatalyst for conversion of glucose to PHCA by incorporation of the wildtype PAL from the yeast Rhodotorula glutinis plus the plant cytochrome P-450 and the cytochrome P-450 reductase into E. coli. In yet another embodiment, the present invention provides for the developing of a new biocatalyst through mutagenesis of the wild type yeast PAL which possesses enhanced tyrosine ammonia-lyase (TAL) activity.

Disclosed are nutritional compositions and methods of using the compositions for treating or preventing osteoporosis. The compositions comprise (A) those dried fruit solids that inherently comprise flavonoids, hydroxycinnamic acids, and a fiber component of which at least about 20% by weight is soluble fiber, and (B) a soluble, indigestible oligosaccharide in addition to any soluble fiber inherently in the dried fruit solids. The dried fruit solids may also be characterized as those selected from dried plum, dried grape, dried date, or dried fig. The combination of dried fruit solids (e.g., dried plum solids) and soluble indigestible oligosaccharides (e.g., fructooligosaccharides) have been found to be surprisingly more effective in affecting bone mineral density than either component when used alone, thus allowing for reduced concentrations of such ingredients in a nutritional product form such as a beverage or solid nutritional bar.

An improved cosmetic and dermatological composition and a method for treating hyperpigmented skin is disclosed. The composition demonstrates an enhanced ability to lighten mammalian skin color, and is nontoxic and nonirritating. The composition comprises a hydroxycinnamic acid or a methoxycinnamic acid dissolved in a compound having one or more hydroxy groups, like a PEG-4 through PEG-20, a monoC_1-4alkyl ether of an ethylene glycol, or a monoC_1-4alkyl ether of a propylene glycol oligomer, and/or a silicone fluid.

Anti-reflective compositions and methods of using those compositions to form circuits are provided. The compositions comprise a polymer dissolved or dispersed in a solvent system. In one embodiment, the compositions comprise less than about 0.3% by weight of a strong acid. In another embodiment, the weight ratio of strong acid to weak acid in the composition is from about 0:100 to about 25:75. Examples of preferred weak acid compounds include phenolic compounds (e.g., Bisphenol S, Bisphenol A, α-cyano-4-hydroxycinnamic acid), carboxylic acids (e.g., acetic acid), phosphoric acid, and cyano compounds. The polymer and other ingredients are preferably physically mixed in a solvent system. The resulting compositions are spin bowl compatible (i.e., they do not crosslink prior to the bake stages of the microlithographic processes or during storage at room temperature).

The present invention provides several methods for biological production of para-hydroxycinnamic acid (PHCA). The invention is also directed to the discovery of new fungi and bacteria that possess the ability to convert cinnamate to PHCA. The invention relates to developing of a new biocatalyst for conversion of glucose to PHCA by incorporation of the wild type PAL from the yeast Rhodotorula glutinis into E. coli underlining the ability of the wildtype PAL to convert tyrosine to PHCA. The invention is also directed to developing a new biocatalyst for conversion of glucose to PHCA by incorporation of the wildtype PAL from the yeast Rhodotorula glutinis plus the plant cytochrome P-450 and the cytochrome P-450 reductase into E. coli. In yet another embodiment, the present invention provides for the developing of a new biocatalyst through mutagenesis of the wild type yeast PAL which possesses enhanced tyrosine ammonia-lyase (TAL) activity.

The present invention provides an antimicrobial composition comprising an antimicrobial effective amount (such as a preservative, bactericidal, and/or fungicidal effective amount) of a mixture comprising at least two of:

• • (a) lemon grass oil;
  • (b) cinnamaldehyde, cinnamon oil, Cinnamomum cassia, cinnamon extract, cassia leaf oil, 3,4-dihydroxycinnamic acid or salt thereof, or a mixture thereof;
  • (c) sorbic acid, or a salt thereof;
  • (d) erythorbic acid, or a salt thereof;
  • (e) benzoic acid, or a salt thereof;
  • (f) arabinogalactan, galactoarabinan, or a mixture thereof;
  • (g) a hexahydro-iso-alpha-acid, tetrahydro-iso-alpha-acid, or a mixture thereof;
  • (h) Achillea fragrantissima (Santolina fragrantissima Forssk., lavender cotton) oil; and
  • (i) δ-gluconolactone.

The present invention also provides a product (preferably a product other than a foodstuff, pharmaceutical, or cosmetic) comprising a preservative effective amount of cinnamaldehyde or a mixture of cinnamaldehyde and one or more alkanol-dialkyl hydantoins.

A macromonomer of the present invention comprises at least functional group and a plurality of hydrophilic moieties. Such a functional group can be an ethylenically unsaturated group that comprises acrylate, methacrylate, sinapate (or 3,5-dimethoxy-4-hydroxycinnamate), cinnamate (or 3-phenylacrylate), senecioate (or 3,3-dimethylacrylate), crotonate, maleate, fumarate, itaconate, vinyl, allyl, or styryl group. Polymeric materials comprise such a macromonomer are used advantageously to provide a hydrophilic or lubricious (or both) coating on polymeric articles, such as medical devices. Such polymeric materials can comprise units of other hydrophilic monomers.

The present invention provides an antimicrobial composition comprising an antimicrobial effective amount (such as a preservative, bactericidal, and/or fungicidal effective amount) of a mixture comprising at least two of: (a) lemon grass oil; (b) cinnamaldehyde, cinnamon oil, cinnamomum cassia, cinnamon extract, cassia leaf oil, 3,4-dihydroxycinnamic acid or salt thereof, or a mixture thereof; (c) sorbic acid, or a salt thereof; (d) erythorbic acid, or a salt thereof; (e) benzoic acid, or a salt thereof; (f) arabinogalactan, galactoarabinan, or a mixture thereof; (g) a hexahydro-iso-alpha-acid, tetrahydro-iso-alpha-acid, or a mixture thereof; (h) Achillea fragrantissima oils, Santolina fragrantissima oils, Forssk oils, Lavender cotton oils; and (i) Glucono Delta Lactone. The present invention also provides a product (preferably a product other than a foodstuff, pharmaceutical, or cosmetic) comprising a preservative effective amount of cinnamaldehyde or a mixture of cinnamaldehyde and one or more alkanol-dialkyl hydantoins.

The invention discloses an alpha-cyano-4-hydroxy cinnamic acid derivative with aldose reductase inhibition activity and a preparation method and application thereof. The structure of the compound is as shown in formula I. The preparation method comprises the following steps: firstly reacting alpha-cyano-4-hydroxy cinnamic acid with a diamine compound protected by N-tert-butyloxycarbonyl (Boc) to obtain N-Boc-protected alpha-cyanocinnamic carbamide. After removal of a protective group, namely Boc from the compound, the alpha-cyano-4-hydroxy cinnamic acid derivative is obtained by reaction with N-acyl alpha-amino acid (natural or unnatural). The compound disclosed by the invention has inhibition activity against aldose reductase, and can be applied to preparation of medicaments for treating diabetic complications, such as diabetic retinopathy, diabetic senile dementia, disorders of nerve endings and other diseases.

Topically applicable, improvedly photostabilized, photoprotective cosmetic/dermatological compositions contain (i) an effective UV-screening amount of at least one dibenzoylmethane sunscreen and an effective photostabilizing amount of (ii) at least one bis-resorcinyl triazine compound and (iii) at least one compound accepting the excited triplet level energy of said at least one dibenzoylmethane sunscreen, notably at least one 4-hydroxybenzylidenemalonate compound, 4-hydroxycinnamate compound, fluorene compound, piperidinol salt, or mixture thereof, formulated into (iv) a topically applicable, cosmetically/dermatologically acceptable support therefor.

The invention relates to preparation of a poplar antimicrobial compound and application thereof as an antimicrobial. The antimicrobial compounds are traced and separated from 107 branches of poplar in Europe and America; and through structural analysis, the antimicrobial compounds are para-hydroxy fat alkanol ester cinnamate, 5-hydroxy-7-methoxyflavone, 5, 7-ferrichrysin and 5, 7-dihydroxyflavanol. The invention first defines that flavone compounds are major antimicrobial compositions in the poplar, and simultaneously defines that extracts of the 107 poplars in Europe and America and antimicrobial compositions thereof have obvious inhibition activity to various phytopathogens, and can be used for prevention and treatment of insect pests and plant disease.

A process for producing a phenolic polymerizable compound represented by formula (1) or (2); wherein X¹-X⁹ independently represent a hydrogen atom, a hydroxy group, a saturated or unsaturated linear or branched alkoxy group having 1-10 carbon atoms, or a saturated or unsaturated linear or branched alkyl group having 1-10 carbon atoms; Y represents a hydrogen atom, a hydroxy group, a saturated or unsaturated linear or branched alkoxy group having 1-10 carbon atoms, a saturated or unsaturated linear or branched alkyl group having 1-10 carbon atoms, or a group represented by formula (6); and Z represents a hydrogen atom or a group represented by formula (3), which is characterized by heating a 4-hydroxycinnamic acid compound in the presence of a metal salt.

New ester derivatives of hyaluronic acid with hydroxy-cinnamic acid, their rheological and anti-radical properties are used as protective agents in dermatology.