193 results about "Phenoxyacetic acid" patented technology

This invention provides methods and devices for spatially separating at least first and second components in a sample which in one exemplary embodiment comprises introducing the first and second components into a first microfluidic channel of a microfluidic device in a carrier fluid comprising a spacer electrolyte solution and stacking the first and second components by isotachophoresis between a leading electrolyte solution and a trailing electrolyte solution, wherein the spacer electrolyte solution comprises ions which have an intermediate mobility in an electric field between the mobility of the ions present in the leading and trailing electrolyte solutions and wherein the spacer electrolyte solution comprises at least one of the following spacer ions MOPS, MES, Nonanoic acid, D-Glucuronic acid, Acetylsalicyclic acid, 4-Ethoxybenzoic acid, Glutaric acid, 3-Phenylpropionic acid, Phenoxyacetic acid, Cysteine, hippuric acid, p-hydroxyphenylacetic acid, isopropylmalonic acid, itaconic acid, citraconic acid, 3,5-dimethylbenzoic acid, 2,3-dimethylbenzoic acid, p-hydroxycinnamic acid, and 5-br-2,4-dihydroxybenzoic acid, and wherein the first component comprises a DNA-antibody conjugate and the second component comprises a complex of the DNA-antibody conjugate and an analyte.

Described is a method for freshening fabric articles by means of spraying the articles with an aqueous slurry of microcapsules having rupturable melamine-formaldehyde polymeric walls, containing substantive and efficacious functional substances, e.g., malodour counteractants and / or fragrances. The slurry may optionally contain non-confined functional substances, e.g. malodour counteractants and / or fragrances. The method is effective for the deposition of effectively-rupturable malodour suppressant and / or fragrance emitting microcapsules onto fabrics wherein the resulting emitted fragrance activity and / or malodour counteractant activity is long-lasting and where the resulting substantive aroma is aesthetically pleasing over the long period of time for which it is effective. Also described are efficacious and substantive malodour counteractant compositions useful for the aforementioned process containing a malodour composition composed of zinc ricinoleate and at least one of: 1-cyclohexylethan-1-yl butyrate; 1-cyclohexylethan-1-yl acetate; 1-cyclohexylethan-1-ol; 1-(4′-methylethyl)cyclohexylethan-1-yl propionate; and / or 2′-hydroxy-1′-ethyl(2-phenoxy)acetate. In addition, described are efficacious microcapsule slurries useful for the aforementioned process containing microcapsules having melamine-formaldehyde polymeric capsule walls with the microcapsules being in contact with one or more polymeric silicone phospholipids.

The invention discloses a weeding composition for a wheat field. The active ingredients of the weeding composition comprise (A): any one of carfentrazone and clodinafop-propargyl, and (B): any one or two of tribenuion methyl, bensulfuron methyl, fluroxypyr, florasulam, pyrazosulfuron, isoproturon and MCPA-Na (2-methyl-4-chloro-phenoxyacetic acid-sodium); or comprise two ingredients of A and any one of B. The ratio of two ingredients is 1-70:1-70, and the ratio of three ingredients is 1-50:1-50:1-50. The composition of the invention can be prepared into missible oil, oil suspension agent, wettable powder, water dispersible granules and the like, and has the advantages of good weeding effect, wide weeding spectrum, small use amount, low residue, safety to crops and low cost. Moreover, the composition has good prevention and control effect in removing broadleaf weeds and partial grass family weeds, the prevention and control rate is over 90%, and the harm of weeds in the wheat field can be essentially controlled throughout the season by once application.

Described are synergistically-effective compositions consisting essentially of zinc ricinoleate or solutions thereof and one or more of the substituted monocyclic organic compounds: 1-cyclohexylethan-1-yl butyrate; 1-cyclohexylethan-1-yl acetate; 1-cyclohexylethan-1-ol; 1-(4′-methylethyl)cyclohexylethan-1-yl propionate; and / or 2′-hydroxy-1′-ethyl(2-phenoxy)acetate and uses of same and compositions containing same for preventing and / or suppressing malodors. Also described for the purpose of application to an inanimate laminar substantially solid surface are malodor-suppressing composition-containing stick articles containing an ester-terminated polyamide or an amide-terminated polyamide structural support polymer in combination with the aforementioned synergistically-effective zinc ricinoleate-substituted monocyclic organic compound composition. Also described is a package for conveniently handling the aforementioned stick article.

The invention relates to a herbicide composite used in a paddy field. The active ingredient of the composite is formed by one or two of metamifop, bensulfuron-methyl, pyrazosulfuron, quinclorac, bentazone, bispyribac-sodium, 2-methyl-4-chloro-phenoxyacetic acid, penoxsulam and imidazolinone herbicides so as to form a binary herbicide composite or a ternary herbicide composite. The herbicide composite used in the paddy field can effectively remove various weeds in grass family, broad leaf weeds and cyperaceae weeds in the paddy field in a disposable way, and has special effects on cockspur grasses, moleplant seeds, crabgrass and the like which are difficult to be prevented in the directly-sown paddy fields.

The invention relates to a new pharmacotherapeutical strategy, to an anti-stress, anti-impairment and anti-aging drug and to a process for its manufacturing. The drug has an etio-pathogenic and homeostatic action, was preclinically tested and clinically checked up in geriatric, neurologic, psychiatric and stress-dependent pathology. The drug achieves a synergistic biological, neurometabolic and cell-trophic composition, being elaborated by the association of the following active principles: a) against oxidative and catabolic stress; methionine with aminoethanol phenoxyacetates and / or aminoethyl phenoxyacetamides; b) against anabolic stress; hydroxopyrimidine carboxylates and / or oxopyrrolidine acetamides with potassium, zinc and lithium; c) vasodilative and normolipidemic; nicotinic, alcohol and / or acid, or its derivatives, with magnesium and iodine; d) energo-active and e) anti-toxic; aspartate; fructose; vitamin B1; vitamin B6; monoacid phosphate and sulfate. The process for manufacturing the drug stipulates; a) pharmaceutical preparation in two complementary types of capsules or coated tablets, gastrosoluble and enterosoluble, the last being enteric coated; b) prolonged-release of vasodilator from the enterosoluble unit.

The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.

The invention relates to a method for synthesizing a phenoxyacetic acid derivative. The method comprises the steps of mixing a salt compound of phenol or methyl phenol and a salt compound of chloroacetic acid, putting the mixture in a solvent to carry out a heating reaction, acidifying with an inorganic acid to obtain phenoxyacetic acid, dissolving the phenoxyacetic acid in a solvent, adding a catalyst to the solvent, passing chlorine in the solvent and carrying out a heating chlorination, cooling and crystallizing to obtain a chlorinated phenoxyacetic acid derivative or a methyl phenoxyacetic acid derivative. Compared with a conventional method, the method provided by the invention can recycle the solvent of the reaction system and wastewater for cycle use during the reaction process, can meet self-production balance and realize recycle and reuse of a sealed system, and has a yield higher than 95%, a content larger than 98%, the recycle and reuse utilization rate of the solvent higher than 95% and emission reduction of the waste water in the whole production process higher than 95%.

The invention provides a chloration method for phenoxyacetic acid and derivatives thereof, which comprises the following steps that: raw materials of the phenoxyacetic acid or the derivatives of the phenoxyacetic acid and chlorinating agents take reaction at a certain temperature in organic solvents under the effect of catalysts, wherein the chlorinating agents can be chlorine gas, sodium hypochlorite, calcium hypochlorite and sulfuryl chloride, the catalysts can be lewis acid and sulfurated substances, and solvents can be dichloromethane, dichloroethane, trichloromethane, carbon tetrachloride, formic acid, ethyl acetate, benzene, toluene, dimethylbenzene, chlorobenzene and o-dichlorobenzene. The method has the advantages that the operation can be carried out under the waterless condition, the generation of a large amount of industrial waste water is avoided, the used catalysts are safe and are easy to obtain, the solvents can be cyclically used, and the industrialization is easy.

The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.

The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.

The rooting agent suitable for stem planting of golden camellia branch consists of 2, 4-dichloro phenoxyacetic acid, 3-indole butyric acid, sodium guaiacol mononitrate, sodium hydroxide and borax. It is diluted before being used for stem planting of golden camellia branch in spring, summer and autumn, and survival rate of golden camellia seedling may reach 93-98 %. The present invention makes it possible to protect, develop and utilize golden camellia via fast industrial seedling growing.

The invention provides humic acidic ammonium and a preparation method and application thereof. the preparation method of humic acidic ammonium comprises the following steps: mixing weathered coal and ammonium bicarbonate in a weight ratio of 2-4:1, and stirring and rolling at 16-35 DEG C to perform amination reaction and prepare humic acidic ammonium, wherein the the stirring rate is 30-40r / min, the stirring time is 1-2hr, and the rolling pressure is 1.6-2kg / cm<2>. The invention also provides the humic acidic ammonium prepared by the above method and the application thereof in the complex synergism of the herbicide. The invention also provides a herbicide complex which is the aqueous solution combined by the humic acidic ammonium and organophosphorus herbicide, and another herbicide complex which is the aqueous solution combined by the humic acidic ammonium, sulfonylurea herbicide and phenoxyacetic acid herbicide. The solubility of the humic acidic ammonium prepared by the method of the invention is more than 90%, and the humic acidic ammonium has various active components and can ensure that the herbicide effect of the herbicide complex is exerted.

The invention relates to microbial bactericide with plant additives. The technical scheme is that: the microbial bactericide comprises 20 to 30 percent of bacillus cereus, 20 to 30 percent of bacillus subtilis, 2 to 5 percent of DA-6, 1 to 5 percent of titanium dioxide, 15 to 25 percent of validamycin, 1 to 5 percent of heteroauxin, 1 to 5 percent of compound sodium nitrophenolate, 1 to 5 percent of sodium phenoxyacetate, 1 to 5 percent of nitrophenosodium, 1 to 5 percent of 4-iodine phenoxyacetic acid and 15 to 20 percent of polyaspartic acid. Microbial sterilization is adopted, so that the using amount of chemical pesticide is reduced, environmental pollution is reduced, soil is activated and absorption and utilization of organic fertilizer by crops are improved. Trace elements for plant growth are provided, so that diseases and insect damage are eliminated, drought resistance, cold resistance, lodging resistance and the like are achieved, aims of increasing yield, and improving crop quality and reducing cost are fulfilled. Popularization and application of the microbial bactericide contribute to stable production and production increase of grains in China.

The preparation of an intermediate, a process for the preparation thereof and the process of preparing [4-[3,3-Bis-(4-bromo-phenyl)-allyloxy]-2-methyl-phenoxy]-acetic acid using this intermediate are described.

The invention relates to soluble granules or tablets which take 2-methyl-4-chloro-phenoxyacetic acid salt as active component and comprises an auxiliary additive, wherein the auxiliary additive is acceptable in the aspect of pesticide; the weight percent of the 2-methyl-4-chloro-phenoxyacetic acid salt active component is 2-98%; the auxiliary additive which is acceptable in the aspect of pesticide comprises one or combination of more than two in wetting agent, adhesive, disintegrating agent, defoaming agent, filler and the like. The invention also relates to a preparation method of the 2-methyl-4-chloro-phenoxyacetic acid salt soluble granules (tablets). The method comprises the steps of enabling 2-methyl-4-chloro-phenoxyacetic acid to have reaction with alkaline matter to produce salt, and then directly feeding the auxiliary additive into the product without taking out the product, or feeding the auxiliary additive into 2-methyl-4-chloro-phenoxyacetic acid salt raw powder, and pelleting or tabletting to obtain the 2-methyl-4-chloro-phenoxyacetic acid salt soluble granules (tablets).

The invention discloses a herbicide composition containing glyphosate, MCPA (2-methyl-4-chloro-phenoxyacetic acid) and carfentrazone-ethyl. The herbicide composition is characterized in that the pesticide active ingredients of the composition are glyphosate or salts thereof, MCPA or salts or esters thereof and carfentrazone-ethyl; based on the herbicide composition, the weight percent of the pesticide active ingredients is 31.1-85%, wherein the weight percent of the glyphosate or salts thereof is 30-70%, the weight percent of the MCPA or salts or esters thereof is 1-30%, the weight percent of the carfentrazone-ethyl is 0.1-20% and the balance is non-pesticide ingredients. The dosage forms of the herbicide composition are wettable powder, water dispersible granules, soluble powder, soluble granules, aqueous solutions, emulsion in water and microemulsion. The composition has the advantages that after compounding, the herbicide composition has obvious synergistic effects, expands the weed control spectrum, increases the weed control speed, obviously reduces the usage amount and numbers of use of herbicides and can be applied to controlling imperata cylindrica, Bidens pilosa, dicranopteris dichotoma, eleusine indica, erigeron canadensis and other weeds in arable lands and non-arable lands.

The purpose in this invention is to providing drugs for treating or preventing duplication of hypertension with serum hyperuricemia and / or hypercholesterolemia that is much frequency among the duplication onset in geriatric diseases. This invention is related to drugs for treating or preventing duplication of hypertension with serum hyperuricemia and / or hypercholesterolemia of which active principles are 2-propyl-3- {[2'-(1H-tetrazole -5-yl) biphenyl -4-yl]methyl}-5, 6, 7, 8-tetrahydrocyclohepta imidazole -4-(3H) - one and that prodrug or that salt. Pratosartan is able to use in combination with one or more than two diuretics chosen from sulfonamide-, phenoxyacetic acid- and thiazide-type diuretics, triamterene, amiloride, spironolactone, potassium canrenoate and traxanox sodium. Also, pratosartan is able to use in combination with one or more than two hypolipidemic drugs chosen from statins, fibrates, cholesterol absorption inhibitors, cholesterol sequestrants and cholesterol excretion enhancers.

The invention discloses a phenoxyacetic acid derivative, a preparation process thereof and use thereof as medicaments, and provides a compound shown as formula (I) and a physiologically acceptable salt thereof, wherein the symbols are as defined in the specification. The compound or physiologically acceptable salt thereofhas GPR40 (G-protein-coupled receptor) regulation function, can cause increase in insulin release, and is useful to be used as an insulin secretagogue or medicaments for prevention or treatment of diabetes and the like.

A process for recovering residual amounts of 6-APA, on the order of 10 g / L or less, from a predominantly aqueous liquor containing phenoxyacetic acid and less than about 2% organic solvents.

The invention provides a novel water-insoluble porphyrin, namely 5-(4-phenoxyacetic acid)-10,15,20-triphenyl zinc porphyrin. The water-insoluble porphyrin is obtained by adopting 5-(4-hydroxyphenyl)-10,15,20-triphenyl zinc porphyrin as a raw material through coordination with zinc acetate, ethyl chloroacetate substitution reaction and acid neutralization reaction. Because the hydroxyl in the 5-(4-phenoxyacetic acid)-10,15,20-triphenyl zinc porphyrin is converted into soluble carboxyl, the 5-(4-phenoxyacetic acid)-10,15,20-triphenyl zinc porphyrin can be dissolved into water to a certain extent and particularly has favorable dissolubility under the alkaline condition. Compared with the hydroxyl, the carboxyl is better qualified for a task of electronic transmission, and the invention provides a good platform for further researching a photoelectronic functional material.

The invention discloses a chlorination method for phenoxyacetic acid, which mainly solves the problems of high cost, low yield, poor selectivity and environment pollution of the existing phenoxyacetic acid prepared with the existing chlorination method for phenoxyacetic acid. The chlorination method comprises the following operation steps of: 1. preparing a phenoxyacetic acid solution; 2. carrying out electrolysis; and 3. purifying. The chlorination method has the advantage of simple step, is convenient to operate, is operated at the room temperature and does not need any catalyst so as to lower preparation cost; in addition, the chlorination method has good selectivity, and methyl 4-chlorophenoxyacetic acid, 2,4-dichlorophenoxy aceticaci and 2,4,6-trichlorophenoxyacetic acid can be prepared respectively under different electrolysis conditions with the respective yield of over 90%; and in the chlorination method, chlorine does not serve as a raw material, thereby causing small environment pollution. The chlorination method is mainly used for preparing methyl 4-chlorophenoxyacetic acid, 2,4-dichlorophenoxy aceticaci and 2,4,6-trichlorophenoxyacetic acid.

The invention discloses a method for rapidly detecting a phenoxyacetic acid herbicide in soil. The method comprises the following four steps of: extracting a target object in the soil, purifying N-propyl ethanediamine, preparing a standard storage solution and a standard working solution, and carrying out liquid chromatogram-tandem mass spectrum determination. The method disclosed by the invention overcomes the disadvantages of a sample processing method in the prior art; and aiming at a tobacco-planting soil sample, an enzymolysis condition, a solid-phase extraction condition and relative detection conditions of LC-MS / MS are optimized, and mainly an ion source condition, a chromatographic column and a mobile phase system are optimized. Compared with a traditional gas chromatography, a base material dispersed solid-phase extraction method is used for detecting dicamba, 2,4-D and 2,4,5-T. The pre-treatment process is simplified and the analysis sensitivity is improved.

The invention discloses an open tubular capillary column of a zirconium-containing metal organic framework material NH2-UiO-66 and application of the open tubular capillary column. A preparation method of the open tubular capillary column includes the following steps: feeding a GLYMO-IDA-silane solution in a pretreated capillary column, and modifying a carboxyl on the surface of a capillary tube; and then successively feeding zirconium chloride, a 2-aminoterephthalic acid solution and a mixture of the zirconium chloride and the 2-aminoterephthalic acid solution in the capillary column successively, and enabling the zirconium-containing metal organic framework material NH2-UiO-66 to grow on the surface of the capillary column in situ. The preparation method is simple in process, easy to operate and low in cost, and is pollution-free to the environment. The prepared NH2-UiO-66 modified capillary column has good separating effect on phenoxyacetic acids water quality pollutants and nucleosides analytes.

The invention provides a 2,4-dichlorophenoxyacetic acid preparation method including the following steps: A) providing phenoxyacetic acid; B) mixing hydrochloric acid, an oxidizing agent and the phenoxyacetic acid of the step A), carrying out a chlorination reaction in the presence of a chlorination catalyst, to obtain 2,4-dichlorophenoxyacetic acid, wherein the molar ratio of the phenoxyacetic acid to the hydrochloric acid to the oxidizing agent is 1 to (2-200) to (2-200), and the molar ratio of the hydrochloric acid to the oxidizing agent is 1 to (0.1-10). The 2,4-dichlorophenoxyacetic acid preparation method provided by the invention only needs one-step chlorination reaction, and then the 2,4-dichlorophenoxyacetic acid can be obtained; while the purity and yield of the 2,4-dichlorophenoxyacetic acid are ensured, the production process of the 2,4-dichlorophenoxyacetic acid is simplified. Moreover, the preparation method provided by the invention has no 'three wastes' emissions and achieves greenization of synthesis of the product.

The invention relates to a novel active multi-composite microfertilizer and a preparation method thereof. The technical scheme is that: the novel active multi-composite microfertilizer comprises 25 to 35 percent of organic humic acid, 12 to 15 percent of amino acid, 12 to 20 percent of vegetable protein, 20 to 30 percent of plant activating enzyme, 3 to 5 percent of heteroauxin, 3 to 5 percent of compound sodium nitrophenolate, 3 to 5 percent of phenoxyacetic acid sodium salt and 22 to 30 percent of bacillus cereus. The novel active multi-composite microfertilizer overcomes the defects of the conventional chemical fertilizer, increases the utilization ratio of the chemical fertilizer, reduces the using amount of the chemical fertilizer, reduces cost, increases yield obviously, reduces environmental pollution, activates soil, increases absorption and utilization ratio of the organic fertilizer by crops, and fulfills the aims of increasing yield, improving efficiency, protecting environment and reducing cost.

The invention relates to a synergistic weeding composition, and particularly relates to the synergistic weeding composition which is a ternary composition of pyribenzoxim, 2-methyl-4-chloro-phenoxyacetic acid or a derivative thereof, and bentazone, and used in rice fields. The synergistic weeding composition comprises three active ingredients consisting of (a) the pyribenzoxim, (b)the 2-methyl-4-chloro-phenoxyacetic acid or the derivative thereof, and (c)the bentazone in a weight ratio of 1-100: 1-100:1-100. The weeding composition also can comprise a safety agent. The weeding composition is prepared through ternary complex formulation of the pyribenzoxim, the 2-methyl-4-chloro-phenoxyacetic acid or the derivative thereof, and the bentazone, so that defects caused by single use of the pyribenzoxim can be effectively overcome, a weed killing spectrum for weeds is enlarged, and at the same time generation of drug resistance is postponed. The weeds in the rice fields can be basically removed by using the weeding composition for once, so that the weeding composition is labor saving, time saving, and effort saving, can alleviate some of the rural labor shortage, and at the same time can play a certain role in increase in both production and income of rice. The weeding composition shows an enhanced effect on the control of broadleaf weeds, gramineae weeds and cyperaceae weeds in the rice fields.

Novel compounds having excellent PPAR α / γ agonist effects and having desirable properties for medicaments are provided. Peroxisome proliferator-activated receptor α / γ agonists of the general formula (I): (wherein Q is an optionally-substituted benzene or pyridine ring; R1 and R2 each are an optionally-substituted phenyl group or 5- or 6-membered aromatic heterocyclic group; X Y, and Z are independently C, O, S or N; R3 to R9 each are a hydrogen atom, a lower alkyl group, etc.; n is an integer of 0 to 3).

In order to solve problems that an existing phenoxyacetic acid production process of low yield and environment pollution caused by a great deal of generated wastewater, the invention provides a ternary-cycle type no-waste-free preparing method for phenoxyacetic acid. The method is characterized by being a production process which takes ferrous chloride-EDTA (Ethylene Diamine Tetraacetic)-sodium iodide as a catalyst and adopts a ternary-cycle mode. The method comprises the following steps: in two phases of a water phase and an organic phase, condensing sodium phenate and sodium chloroacetate to generate sodium phenoxyacetate, wherein the sodium phenate is excessive, and excessive phenol is dissolved in a solvent for being cycled to realize mother liquor circulation; washing the sodium phenoxyacetate in a solvent to recycle entrained phenol to realize washing liquor circulation; producing the phenoxyacetic acid from the sodium phenoxyacetate by virtue of a four-phase reaction, cooling and crystallizing to realize acidification circulation. The method disclosed by the invention can be used for realizing effective separation of the sodium chloride and the phenoxyacetic acid, and is free of wastewater in the whole process; and moreover, the yield in the circulating process can be over 98%.

The invention provides a method for preparing 2,4-dichlorphenoxyacetic acid. The method comprises the step S1 of causing haloacetic acid and alkali metal alkoxide react in an alcohol solvent toobtain halogenated acetate, the step S2 of causing the halogenated acetate and phenoxide to react in the alcohol solvent to obtain phenoxyacetic acid salt, the step S3 of causing the phenoxyacetic acid salt to undergo chlorination in the alcohol solvent, and obtaining 2,4-dichlorobenzene acetate, and the step S4 of acidizing 2,4-dichlorobenzene acetate to obtain 2,4-dichlorphenoxyacetic acid. Compared with the prior art, the method enables chlorination to be performed in an anhydrous system, reaction selectivity is good, by-products are fewer, the yield is high, the 2,4-dichlorphenoxyacetic acid can be obtained after acidification, and the 2,4-dichlorphenoxyacetic acid is simple to prepare.