The invention belongs to the technical field of medicines, and specifically provides a synthetic method for 8-hydroxyl-2,2,14,14-tetramethyl-pentadecanedioic acid. The synthetic method comprises the following steps: (1) pouring 8-keto-2,2,14,14-tetramethyl-pentadecanedioic acid into purified water, and adding a proper amount of alkali until the 8-keto-2,2,14,14-tetramethyl-pentadecanedioic acid iscompletely dissolved so as to obtain 8-keto-2,2,14,14-tetramethyl-pentadecanediate; (2) adding sodium borohydride into an above-mentioned reaction solution, and carrying out a carbonyl reduction reaction under the condition of 20 to 25 DEG C so as to obtain 8-hydroxyl-2,2,14,14-tetramethyl-pentadecanediate; and (3) adding concentrated hydrochloric acid into an above-mentioned reaction solution until the pH value of the reaction solution is adjusted to 1 to 3 so as to generate the 8-hydroxyl-2,2,14,14-tetramethyl-pentadecanedioic acid. The synthetic method provided by the invention reduces theusage amount of the sodium borohydride, decreases the dangerousness of a reaction, simplifies operation, reduces the cost input amounts of a solvent and raw materials, and is applicable to industrialproduction.