79 results about "Flurbiprofen axetil" patented technology

The invention provides a flurbiprofen axetil emulsion for injection and a preparation method thereof. The preparation method comprises the following steps: under the protection of nitrogen, the oil phase is added into the aqueous phase step by step and shearing and mixing for many times to obtain colostrum; 40-60wt% of total oil phase is added into that water phase, shear and mixing are carried out for 10-30min to obtain crude emulsion A, wherein the crude emulsion A is obtained by adding 40-60 wt% of total oil phase into the water phase and mixing for 10-30min; 20-30wt% of total oil phase isadded into that crude emulsion A, and the crude emulsion B is obtained by shear and mixing for 10-30min; Shearing and mixing the crude emulsion B and the remaining oil phase for 10 to 30 minutes; Theoil phase includes flurbiprofen esters, oil phase solvents, emulsifiers and stabilizers, and the aqueous phase includes water for injection and / or osmotic pressure regulators. Under the precondition of the presence of the stabilizer in the oil phase, the invention adopts the oil phase step-by-step and multiple emulsification technology, which can effectively improve the emulsification effect, makethe particle size of the obtained emulsion more uniform, the encapsulation efficiency of the drug higher, and the targeting of the drug to the wound tissue better.

The invention relates to a preparation method of flurbiprofen axetil. The method comprises the following steps of: preparing 4-bromine-2-fluoroanili from fluoroaniline under the action of 1,3- dibromo-5,5-dimethyl hydantoin; condensing 4-bromine-2-fluoroanili with benzene under the action of a catalyst and sodium nitrite to synthesize 4-bromine-2-fluorobiphenyl; carrying out grignard reaction and acidity reaction on the 4-bromine-2-fluorobiphenyl and 2-bromine sodium propionate under the action of a catalyst to generate 2-(2- fluorine-4-biphenylyl) propionic acid; condensing the 2-(2- fluorine-4-biphenylyl) propionic acid with 1-chloroacetic ethyl acetate to generate a target compound flurbiprofen axetil; and carrying out molecular distillation on the flurbiprofen axetil crude product to obtain a flurbiprofen axetil final product.