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Flurbiprofen axetil fat emulsion injection

A technology of flurbiprofen axetil and fat emulsion, applied in the fields of emulsion delivery, making medicines into special physical or taking forms, organic active ingredients, etc.

Inactive Publication Date: 2015-04-08
BEIJING LANDAN PHARMA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no relevant literature reporting that flurbiprofen axetil injection is used for reducing fever

Method used

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  • Flurbiprofen axetil fat emulsion injection
  • Flurbiprofen axetil fat emulsion injection
  • Flurbiprofen axetil fat emulsion injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] prescription:

[0037]

[0038] Process:

[0039] (1) Preparation of water phase: add glycerin to water to dissolve, heat to 70°C, and set aside;

[0040] (2) Preparation of oil phase: Refined soybean oil is heated to 70°C, egg yolk lecithin (80% phosphatidylcholine content, 17% phosphatidylethanolamine content) is added to dissolve respectively, and flurbiprofen axetil is added, stirred to make its dissolution;

[0041] (3) Preparation of colostrum: Add the oil phase of step (2) into the water phase of step (1), at a temperature of 70°C, high-speed shear dispersion, shear speed of 10,000 rpm, and time of 15 minutes, to form colostrum;

[0042] (4) pH value adjustment: quickly cool down the colostrum in step (3) below 30°C, and adjust the pH value to 4.5-6.5 with disodium hydrogen phosphate citric acid buffer solution (the molar ratio of disodium hydrogen phosphate to citric acid is 4:1) ;

[0043] (5) High-pressure homogenization: the colostrum in step (4) is ho...

Embodiment 2

[0047] prescription:

[0048]

[0049] Process:

[0050] (1) Preparation of water phase: add glycerin to water to dissolve, heat to 70°C, and set aside;

[0051] (2) Preparation of oil phase: Refined soybean oil is heated to 70°C, egg yolk lecithin (80% phosphatidylcholine content, 17% phosphatidylethanolamine content) is added to dissolve respectively, and flurbiprofen axetil is added, stirred to make its dissolution;

[0052] (3) Preparation of colostrum: Add the oil phase of step (2) into the water phase of step (1), at a temperature of 70°C, high-speed shear dispersion, shear speed of 10,000 rpm, and time of 15 minutes, to form colostrum;

[0053] (4) pH value adjustment: quickly cool down the colostrum in step (3) below 30°C, and adjust the pH value to 4.5-6.5 with disodium hydrogen phosphate citric acid buffer solution (the molar ratio of disodium hydrogen phosphate to citric acid is 4:1) ;

[0054] (5) High-pressure homogenization: the colostrum in step (4) is ho...

Embodiment 3

[0058] prescription:

[0059]

[0060]

[0061] Process:

[0062] (1) Preparation of water phase: add glycerin to water to dissolve, heat to 70°C, and set aside;

[0063] (2) Preparation of oil phase: Heat soybean oil, olive oil and medium-chain triglycerides to 70°C, add egg yolk lecithin (80% phosphatidylcholine content, 17% phosphatidylethanolamine content) to dissolve, add fluorine Biprofen axetil drug, stir to dissolve;

[0064] (3) Preparation of colostrum: Add the oil phase of step (2) into the water phase of step (1), at a temperature of 70°C, high-speed shear dispersion, shear speed of 10,000 rpm, and time of 15 minutes, to form colostrum;

[0065] (4) pH value adjustment: quickly cool down the colostrum in step (3) below 30°C, and adjust the pH value to 4.5-6.5 with disodium hydrogen phosphate citric acid buffer solution (the molar ratio of disodium hydrogen phosphate to citric acid is 4:1) ;

[0066] (5) High-pressure homogenization: the colostrum in step ...

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Abstract

The invention relates to flurbiprofen axetil fat emulsion injection which comprises flurbiprofen axetil, oil and egg yolk lecithin, wherein the concentration of the flurbiprofen axetil is 0.1-1.0mg / ml. The flurbiprofen axetil fat emulsion injection prepared by the invention can be used for fever abatement of yeast-induced febrile rats.

Description

technical field [0001] The invention relates to a flurbiprofen axetil fat emulsion injection, in particular to a flurbiprofen axetil fat emulsion capable of reducing fever. Background technique [0002] Flurbiprofen axetil, its chemical name is: (±) 2-(2-fluoro-4-biphenyl)propanoic acid-1-acetoxyethyl ester [0003] Its structural formula is: [0004] [0005] Molecular formula: C 19 h 19 FO 4 [0006] Molecular weight: 330.36 [0007] Flurbiprofen axetil is insoluble in water and needs to be prepared as a liquid emulsion suitable for intravenous injection. Flurbiprofen axetil fat emulsion injection (trade name Kaifen) is a preparation based on the research and development of the concept of drug delivery system, which uses fat emulsion as a drug carrier and encapsulates flurbiprofen axetil. The injection is less irritating and relieves pain. It acts quickly. The advantages of flurbiprofen axetil fat emulsion injection mainly include the following aspects: 1) Targe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/192A61P29/00A61J3/00
Inventor 不公告发明人
Owner BEIJING LANDAN PHARMA TECH
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