164 results about "Flurbiprofen" patented technology

The present invention provides a transdermal external patch, which is an external patch in which an adhesive layer is laminated on a support, wherein the adhesive layer contains styrene-isoprene-benzene as an essential component. An ethylene block copolymer (SIS), a tackifying resin, and a softener, and flurbiprofen as an active ingredient are mixed therein. The external patch containing flurbiprofen makes possible the long-term stable release of the flurbiprofen contained, and the preparation has high stability and very high drug release.

The invention discloses a flurbiprofen-containing external preparation for skin. The preparation is composed of a backing layer, a drug reservoir matrix layer and a protective film, the flurbiprofen-containing external preparation contains 1-10 parts of flurbiprofen, 30 to 100 parts of a gel skeleton component; 0.2-3.5 parts of a cross-linking agent, 1-4 parts of a cross-linking regulator, 1-15 parts of an accelerator, 5.0-52.5 parts of a filling agent, 1-10 parts of a bacteriostatic agent, 5.5-50 parts of a solubilizer and 40-160 parts of a tackifiers. The invention provides the flurbiprofen-containing external preparation, which is safe, effective, non-irritant, good in adhesion and not easy to fall off.

The invention provides a flurbiprofen axetil emulsion for injection and a preparation method thereof. The preparation method comprises the following steps: under the protection of nitrogen, the oil phase is added into the aqueous phase step by step and shearing and mixing for many times to obtain colostrum; 40-60wt% of total oil phase is added into that water phase, shear and mixing are carried out for 10-30min to obtain crude emulsion A, wherein the crude emulsion A is obtained by adding 40-60 wt% of total oil phase into the water phase and mixing for 10-30min; 20-30wt% of total oil phase isadded into that crude emulsion A, and the crude emulsion B is obtained by shear and mixing for 10-30min; Shearing and mixing the crude emulsion B and the remaining oil phase for 10 to 30 minutes; Theoil phase includes flurbiprofen esters, oil phase solvents, emulsifiers and stabilizers, and the aqueous phase includes water for injection and / or osmotic pressure regulators. Under the precondition of the presence of the stabilizer in the oil phase, the invention adopts the oil phase step-by-step and multiple emulsification technology, which can effectively improve the emulsification effect, makethe particle size of the obtained emulsion more uniform, the encapsulation efficiency of the drug higher, and the targeting of the drug to the wound tissue better.