The invention discloses a synthetic method of beta, beta-disubstituted propionate derivative, and belongs to the field of organic synthesis. An aldehyde compound, an iodide and an alcohol are adoptedto synthesize the beta, beta-disubstituted propionate derivative through a one-pot method, and the synthetic method is used for realizing beta-bit arylation and esterification of carbonyl groups of alpha, beta-unsaturated aldehyde to synthesize beta, beta-disubstituted methyl propionate. The synthesis steps of a traditional method are reduced, the reaction yield is increased, and according to thesynthetic method, raw materials are cheap, the operation steps are simple, the reaction condition is mild, and applicability of reaction substrates is greatly enriched.