371 results about "Antibiotic Drugs" patented technology

A method of processing an acellular tissue matrix to give a particulate acellular tissue matrix includes: cutting sheets of dry acellular tissue matrix into strips; cryofracturing the dry acellular tissue matrix strips at cryogenic temperatures; separating the resulting particles by size at cryogenic temperatures; and freeze drying the fraction of particles desired size to remove any moisture that may have been absorbed to give a dry particulate acellular tissue matrix. Rehydration of the dry particulate acellular tissue matrix may take place just prior to use. The particulate acellular tissue may be applied to a recipient site, by way of injection, spraying, layering, packing, in-casing or combinations thereof. The particulate acellular tissue may further include growth and stimulating agents selected from epidermal growth factor, fibroblast growth factor, nerve growth factor, keratinocyte growth factor, platelet derived growth factor, vasoactive intestinal peptide, stem cell factor, bone morphogetic proteins, chondrocyte growth factor and combinations thereof. Other pharmaceutically active compounds may be combined with the rehydrated particulate material including: analgesic drugs; hemostatic drugs; antibiotic drugs; local anesthetics and the like to enhance the acceptance of the implanted particulate material. The particulate material product may also be combined with stem cells selected from mesenchymal stem cells, epidermal stem cells, cartilage stem cells, hematopoietic stem cells and combinations thereof.

The invention provides a feed fermenting agent, fermented feed and a preparation method thereof, and relates to the technical field of animal product cultivation. The feed fermenting agent is mainly prepared from lactobacillus plantarum, enterococcus faecalis, bacillus subtilis, saccharomyces cerevisiae, lactobacillus cellobiosas, a complex enzyme preparation and the like. The fermented feed is prepared from the feed fermenting agent and fermentation raw materials by using a preparation method of carrying out fermentation in a device which is in one-way exhaust. According to the feed fermenting agent and the fermented feed, disclosed by the invention, the problems of high livestock cultivation cost caused by poor nutritive value, low animal digestion and absorption rate and abuse of antibiotic drugs during cultivation, long fermentation time and slow fermentation starting of existing livestock breeding feed are solved, and high absorption and conversion rate of nutrient contents of the fermented feed are achieved; the fermented feed contains a large amount of probiotics for protecting intestine health of animals, so that the organism immunity of the animals is increased, and the use of antibiotics during livestock cultivation is reduced.

A concentrated inhalable formulation of an antibiotic drug such as ciprofloxacin is disclosed. The antibiotic is formulated with sodium acetate and liposome which incorporate antibiotic. The formulation is aerosolized and inhaled for treatment of respiratory tract infections and other medical conditions.

A detection method for detecting HPLC-ESI-MS / MS of 19 species of quinolone drugs simultaneously belongs to the antibiotic drug analysis technology field. The detection method comprises three steps: sample treatment, liquid-phase separation and mass spectrometric detection, wherein the 19 species of quinolone antibiotics in a tissue fluid is subjected to positive ion MRM scan; norfloxacin-D5 is taken as the internal standard; C18 chromatographic columns are adopted for separation; water-methanol containing formic acid is taken as the mobile phase for gradient elution; and the eluent is subjected to mass spectrometric detection. The detection method is characterized in that the organic solvent extraction method is adopted for carrying out the sample pretreatment according to the practical situation of the sample and the different detection sensitivity requirements; norfloxacin-D5 is taken as the internal standard; the C18 chromatographic columns are adopted for separation; and the water-methanol containing formic acid is taken as the mobile phase for gradient elution. The pretreatment process of the method is rapid and convenient, the detection result is reliable and sensitive, and the method is suitable for the analysis and the detection of the quinolone drug residues in animal food.

The invention discloses a low-protein weanling piglet feed which comprises the following raw materials: corns, bean pulp, calcium hydrogen phosphate, dried porcine soluble, fermented bean pulp, fish meal, soybean oil, a premix, sodium chloride, phytase, a compound antioxidant, a compound acidifier, a compound enzyme preparation, a microecological preparation, limestone, L-lysine hydrochloride, L-threonine, DL-methionine, L-tryptophan and a compound traditional Chinese medicine preparation. According to the feed, the crude protein content of piglet full-price daily ration is reduced to 16% from 19%; the compound acidifier, the compound enzyme preparation, the microecological preparation and the compound traditional Chinese medicine preparation are added, so that the immunity of piglets is comprehensively improved and the use of antibiotic drugs is reduced; low-protein high-growth piglet ration is prepared, so that the misunderstanding to the feed consumption caused by farmers is eliminated, the low-protein ration formula technology is really popularized in local, the use of protein raw materials and the diarrhea of the piglets are reduced, and the cost and the N discharge are reduced.

The present invention relates to the technical field of aquaculture and particularly relates to a grass carp feed and a preparation method thereof. The grass carp feed is prepared from the following raw materials by weight: 90% of basic feed, 8% of Chinese herbal medicinal additives and 2% of a growth accelerator. The basic feed includes rice bran, rapeseed meal, wheat bran, soybean meal and distillers' grains. The Chinese herbal medicinal additives include herba houttuyniae, wild chrysanthemums, radix bupleuri, radix puerariae, rhizoma atractylodis macrocephalae, poria cocos, radix ophiopogonis, haws, garlic powder, radish seeds, etc. The growth accelerator includes shrimp shell powder, fish meal, earthworm powder, compound vitamins, amino acids, sucrose, etc. The grass carp feed is comprehensive and balanced in nutrition, can fully satisfy the growth demands of the grass carps and improves the quality of the grass carps. The Chinese herbal medicinal additives can improve the nutritional structures of the feed, enhance immunity, prevent and treat a variety of fish diseases, and can reduce the morbidity and mortality of the grass carps under the condition of not using any antibiotic drugs. The growth accelerator can improve the digestion and utilization rates of the feed, and promote the growth of the grass carps.

The invention discloses an ecological breeding method for grass carp, wherein the ecological breeding method for the grass carp comprises the following steps: (1) building a fish pond; (2) sterilizing the fish pond; (3) stocking the fingerling; (4) feeding and managing; (5) preventing and treating the diseases and insect pests; (6) catching; the ecological breeding method for the grass carp has beneficial effects as follows: the breeding method can raise the breeding quality and yield for the grass carp, the meat flavor of the grass carp bred by the method is delicious, the taste is good, the scientific breeding management can be realized, the diseases and insect pests can be prevented and treated while the fish has health care function, the diseases and insect pests can be thoroughly prevented and treated, the disease control rate is 100%, the method is ecological and environment-friendly, the production cost is low, the economic benefit is high, the large-scale production can be realized; the natural forage grass and granule crushed from the feed are adopted during the breeding process of the grass carp, the commercial compound feed is not used, the chemical synthetic drug and the antibiotic drugs are not used, so the production cost is reduced, the quality of the grass carp is good and the yield is high.

The invention provides biological health padding and a preparation method thereof. The biological health padding includes: rice husk, sawdust, a compound microbial agent, dandelion, argy wormwood leaves, honeysuckle, mint, cogongrass, liquorice, isatis root and water. The padding is suitable for rural small-scale farming, helps to reduce livestock diseases, is beneficial to improvement of livestock and poultry antibody levels, prevention and control of animal digestive tract, respiratory tract and other diseases, and reduction of antibiotic drug residues in animal organism of livestock and poultry, and helps to promote the sustainable development of breeding industry.

The invention discloses a fermented Chinese herbal immunopotentiator used for snakeheads. With the efficacy of prevention, health care, treatment and immunoregulation, the Chinese herbal immunopotentiator is an ideal, green, environmental friendly, safe and novel feed additive for substituting antibiotic drugs. The fermented Chinese herbal feed additive is prepared by subjecting compound Chinese herbal medicines to a process of ''ultrasonic wave assisted extraction of Chinese herbal medicines and multi-strain two-step fermentation'', has the advantages of both Chinese herbal medicines and probiotics, can efficiently condition the intestinal health of snakeheads, treat both symptoms and root causes, consolidate the basis and foster vitality, maintain intestinal microecological balance and an optimal immune state, improves the digestibility of nutrients, improves the body immunity of snakeheads, improves farming profits, and reduces farming risk. The Chinese herbal immunopotentiator can be used for replacing antibiotics, has no adverse effect on snakeheads, is safe to use, and is free of drug residue, drug resistance and other problems, thus having broad market prospects.

The invention provides a rex rabbit feed. The raw materials of the rex rabbit feed are easily obtained; the rex rabbit feed is rich in multiple nutritional components; the appetite of a rex rabbit can be improved so that the rex rabbit likes to eat; the rex rabbit grows with high speed after eating the feed; a great amount of good furs and leathers can be obtained; the cost of feed for breeding rex rabbits is reduced; the immune function of the rex rabbit is enhanced; and the disease prevention, disease curing and anti-virus capacities of the rex rabbit are improved so that the rex rabbit has no need of taking antibiotics drugs. Therefore, no chemical drug residue exists; meanwhile, the breed fertility of a rex rabbit can be effectively improved; the birth rate of a pregnant rex rabbit is increased; the newborn litter weight is increased; the still birth rate is reduced; and the weanling number and the weaning litter weight of a lactational female rex rabbit are increased.

The invention discloses a live pig cough identification method based on a convolutional neural network, and belongs to the field of voice signal processing. Respiratory diseases are one of the most common diseases affecting the pig breeding industry, which seriously restricts the development of the pig industry, cough is one of the obvious symptoms of respiratory diseases in live pigs, early warning of respiratory diseases can be achieved by monitoring and identifying the cough, thereby effectively reducing the spread of the diseases and the use of antibiotic drugs. For the problem that the identification precision is low in an existing live pig cough identification method, especially obvious for intensive large pig houses, the invention provides the method based on a convolutional neuralnetwork based on Ale*Net to recognize the cough, wherein a voice spectrum of voice signals serves as network input, the network can automatically extract the deep features of the voice spectrum, compared with a conventional voice recognition method, the method can effectively improve the cough recognition accuracy and overall recognition accuracy.

The invention discloses a method of removing sulfonamide antibiotics in water by utilizing an ionization radiation technology, belonging to the technical field of nuclear technology application and environmental protection. The method can be used for effectively removing sulfonamide antibiotic drugs (for example sulfamethazine) in water without adjusting pH of wastewater and adding any chemical agent by applying the ionization radiation (high-power electron beams generated by electron accelerator or gamma rays generated by a radioactive source) technology. The method disclosed by the invention is simple, effective, easy to operate and can be used for treating antibiotic wastewater.

The invention discloses a microecological preparation for treating and preventing digestive tract diseases of livestock and poultry and a preparation method and application thereof. the microecological preparation is dried powder obtained by subjecting bifidobacterium, lactobacillus and bacillus to liquid fermentation, centrifuging and low-temperature lyophilizing and compounding with isomaltooligosaccharide and prebiotics. The microecological preparation contains a lot of bioactivators and various viable organisms, and can be used for treating and preventing bacterial diarrhea and lienteric diarrhea of animals, regulating digestion function of the animals, improving body immunity and stress resistance of the animals, promoting animal growing and increasing survival rate of the animals by means of direct feeding, water drinking or adding into feed. The microecological preparation is green and safe, can replace antibiotic drugs to replace intestinal diseases of the animals and has wide application prospect in the field of prevention and treatment of animal diseases.

The invention belongs to the technical field of antibiotic drug synthesis, in particular to a synthesis methodof cefcapene pivoxil hydrochloride. The invention is mainly used for process improvement and optimization of cefcapene pivoxil, and the advantage of the synthesis process of cefcapene pivoxil are obvious; new catalytic agents are used, such as phenol, boric acid and other reagents, thereby improving the product quality, increasing the yield, simplifying the operating steps and realizing greater productivity effect and social effect.

The invention relates to a cyclosporine-containing composition and a preparation method thereof. The compound eye drops are prepared from cyclosporine, anti-inflammatory or antibiotic drugs, a surfactant, a stabilizer, a thickener, an isoosmotic adjusting agent, a pH adjusting agentr and water or oil, the preparation is a mixed suspension agent or an emulsion, and one or two of a high pressure homogenization method and a wet grinding technique is / are combined for use in the preparation method. The cyclosporine compound eye drops have the advantages that the ophthalmic tolerance is excellent, the drug utilization degree is high, the tear secretion of people suffering from xerophthalmia can be effectively improved, the tear film is stabilized, the anti-inflammation function of the anti-inflammatory or antibiotic drugs and the immunoregulation function of cyclosporine can be synergistically exerted, xerophthalmia can be effectively treated, and the compound eye drops have a better treatment effect compared with the separate application of cyclosporine.

The invention discloses a bacterial drug resistance quick projection system and method. The system comprises bacteria genome DNA extracting equipment, bacteria genome fingerprint typing equipment, an intelligent terminal, a cloud server and a bacteria database server, wherein the bacteria genome DNA extracting equipment and the bacteria genome fingerprint typing equipment are connected; the intelligent terminal is connected with the cloud server through internet; the cloud server is further connected with the bacteria database server. The system and the method utilize technologies of internet and safe cloud computing storage, can be applied to not only antibiotic drug resistance spectrum prediction of clinical separation bacterial strains, but also antibiotic drug resistance spectrum prediction of environment separation bacterial strains, are beneficial to guidance of accurate antibiotic use of specialists, reduce the drug resistance gene spreading speed, and can also be an information platform of a bacterial drug resistance monitoring network.

The invention provides an injectable mineralized collagen bone repair material and a preparing method. The bone repair material is prepared from mineralized collagen, collagen, calcium phosphate particles and an antiwashout agent. The preparing method for the material comprises the steps of preparing mineralized collagen powder; dissolving the antiwashout agent; swelling the collagen; carrying out blending; carrying out mould filling and freeze drying; carrying out cross-linking; carrying out grinding and screening. The bone material can be mixed with autoblood, marrow, normal saline and the like, has a good shape after being kneaded, is formed into dough, and has good cohesiveness, injectability and an antiwashout property. The material can be transplanted into a bone defect part in an injected or open operation mode, has good biocompatibility, promotes new bone generation, and can be used in the bone defect of a non-bearing part, path nailing, tooth fossa pulling, interbody fusion cage interior filling, autogenous bone fragment bonding and prefabricated and formed bone material gap supplementing materials. The bone material can carry antibiotic drugs and has a slow-release effect.

The invention provides a bromhexine hydrochlorie injection, which contains bromhexine hydrochlorie and glucose and does not contain ethanol. Without ethanol, the injection can be used together with antibiotic drugs and has good stability. In accord with national regulations for pharmaceutical preparations, the injection has stable and reliable quality, and therefore can be used safely. The invention also provides a preparation method of the bromhexine hydrochlorie injection, comprising the steps of: preparing an isotonic water solution of glucose, then predissolving the bromhexine hydrochlorie in the isotonic water solution, and conducting an ultrasonic treatment. According to the method of the invention, the use of ethanol in the process of preparing a liquid preparation of bromhexine hydrochlorie can be avoided successfully, and possible adverse reactions during clinical application are avoided. With a process simple for operation, the method provided in the invention improves the stability of the injection.

The invention relates to a veterinary antibacterial drug composition containing lysozyme and oligosaccharide and an application thereof. The composition can be prepared into powder, granules, premixes, suspensions and oral solutions by mixing a pharmaceutically acceptable drug carrier with the main drugs of the lysozyme, the oligosaccharide and an antibacterial drug, as well as the auxiliary ingredients of biotin, phytic acid, trehalose, glycine and the like which are used for coordination, according to a conventional preparation method. The composition not only can enhance the self immunity of animals, equalize the absorption of amino acids and mineral substances in vivo and broaden the antimicrobial spectrum, but also has high efficiency, safety and no toxic and side effect and is not easy to lead to drug tolerance and drug resistance. The composition is used for preventing and treating intestinal diseases and respiratory diseases, such as colibacillosis, salmonellosis, pasteurella multocida, staphylococosis and the like, of livestock and poultry. Meanwhile, the developed drugs can be used for effectively substituting the traditional veterinary antibiotic drugs which are easy to lead to drug tolerance.

The present invention is directed to a method of treating respiratory disorders by delivering an aerosol composition of an antibiotic drug to the lung alveoli.

A method for treatment for conditions in human beings associated with either or both reactive arthritis or bursitis comprising administering a combination of a member from each of the following groups of medications: (1) synthetic purine nucleoside analog antiviral drugs, (2) antibiotic drugs, and (3) imidazole drugs. Alternate embodiments of the invention include dual combinations of (A) a member of the synthetic purine nucleoside analog group of antiviral drugs and a member of the antibiotic group of drugs, (B) a member of the antibiotic group of drugs and a member of the imidazole family of drugs, and (C) a member of the synthetic purine nucleoside analog group of antiviral drugs and a member of the imidazole group of drugs.

The invention discloses a core material of feed for a baby pig. The core material comprises the following substances in parts by weight: 3-18 parts of plant essential oil, 6-20 parts of complex multiple ore, 6-20 parts of active factor, 6-24 parts of skimmed milk powder, 2-12 parts of antibacterial peptide, 2-10 parts of an acidifier and 1-8 parts of an edulcorant. The core material of the feed for the baby pig, which is provided by the invention, does not contain any antibiotic drug, avoids problems of drug remaining and drug tolerance which are caused by an antibiotic, improves the pollution to an environment and soil, and improves the quality and the safety of meat; a ration feeding effect can also replace an antibiotic using effect; the demands of the normal growth and a nutrient substance of the baby pig are completely met.

The invention provides a kit and a method for detecting drug-resistant a mutation site of helicobacter pylori. The kit comprises a quinolone antibiotic drug-resistant mutation site mutation primer probe and the retardant sequence and / or a clarithromycin antibiotics drug-resistant mutation site mutation primer probe and the retardant sequence and / or a PRC reagent panel which is matched with the probes above. The detection method comprises the kit, and fluorescent PCR can be adopted to detect whether drug resistance mutation occurs in a tested sample. The detection method is high in sensitivity, strong in specificity, short in time consumption, and has a great advantage in clinical detection of drug resistance of helicobacter pylori.

The invention belongs to the field of pig feeds, and concretely relates to a drug-free growing-fattening pig feed. Every 1000kg of the feed comprises 997.7-999.4kg of low protein ration, 0.1-0.8kg of an enzyme preparation and 0.5-1.5kg of a probiotic-functional oligosaccharide composition, wherein the low protein ration meets a condition that the content of proteins in the feed is not greater than 15.0%, the enzyme preparation comprises xylanase, mannanase and cellulase, and the probiotic-functional oligosaccharide composition comprises Bacillus subtilis, Clostridium butyricum, Bacillus licheniformis and Chitosan oligosaccharide. The feed disclosed in the invention solves a problem of use of antibiotic drugs in feeds, starts with raw material utilization and intestinal tract flora health, has a good growth performance effect, and brings good benefits to raising households.

The invention relates to a feed additive for preventing and treating enteritis of pikes. The feed additive is characterized by being prepared from the following raw materials: plantain herbs, fresh lespedeza pilosa, fresh camphor tree leaves, fresh acorus calamus, humifuse euphorbia herbs, dry red-knees herbs, portulaca oleracea, garlic bulbs, Chinese brake herbs, lespedeza pilosa, table salt and carries through compatibility. A preparation method of the feed comprises the steps of: placing the components, namely the raw materials, into a mixer; fully mixing the materials to obtain a mixture; grinding the mixture in an ultrafine grinder; and passing the ground material through a sieve net, thereby obtaining the feed additive for preventing and treating enteritis of pikes. After the powder-shaped additive is added into the feed, the immunity, the oxidation resisting capability, the stress and the disease resisting capability of the pikes can be enhanced; feeds applicable to the feed additive do not need to be added with antibiotic drugs, so that the produced fish products are pollution-free and has the effect of environmental protection.

The invention provides a glycan feed additive, which contains 0.001%-5.0% of immune polysaccharide based on weight percentage. Due to using the immune polysaccharide, the invention can improve the immunizing power of the bred animals per se, increase the disease resistance of the organism; according to the combination of the formulation, the health caring function and growth stimulating function of the poultry can be achieved without adding any antibiotic drugs into the feed as a feed additive, thereby, the survival rate can be increased, the drug toxic residue of the animal meal product can be avoided.

The present invention provides an herbal dry-mixed feed and a preparation method thereof. The feed is prepared by mixing the following raw materials: corn flour, soybean meal, rapeseed meal, cottonseed meal, wheat bran, rice bran, zeolite powder, calcium bicarbonate, calcium hydrogen phosphate, common salt, mineral elements, amino acids, vitamins and herbal feed additives, wherein the herbal feed additives comprises the following components: herba plantaginis, andrographis paniculata, radix astragali, fructus amomi, medicated leaven, codonopsis pilosula, herba epimedii, radix phytolaccae, polygonatum sibiricum, mangnolia officinalis, schisandra chinensis, cortex acanthopanacis radicis, cyrtomium fortunei, rheum officinale, cordate houttuynia, ginger, mulberry, mint, lophatherum gracile, cape jasmine fruit, scutellaria baicalensis, rhizoma phragmitis, fructus arctii, hawthorn, licorice, and pine needle powder etc. The feed aims to: 1) solve the problems of adverse drugs and heavy metal residues in animals and poor meat quality; 2) producing safe, green, delicious, fragrant and sweet animal meat; 3) enhancing animal immunity, promoting animal growth, reducing morbidity and mortality without the use of any antibiotic drug additives.

The invention discloses a construction method of a gene engineering strain without plasmid and antibiotic resistance screening marker. A pXKF3T5b plasmid is used as the carrier to transform a target gene into a host cell, and then an auxiliary plasmid for expressing the integrase is removed, a kanamycin resistance gene in the integrated carrier is removed, the chromosome is induced by the triclosan to evolve and the evolved strain is fermented and screened, so as to obtain the gene engineering strain without plasmid but with high gene copy number; moreover, a screen marker of the pXKF3T5b plasmid is the fabI gene (for coding enoyl-acetyl carrier protein reductase) in Escherichia coli and the fabI gene is the triclosan resistance gene, thus the obtained gene engineering strain does not have the antibiotic resistance screening marker, furthermore can not cause the spread of the antibiotics drug-resistant bacteria in the environment and can be suitable for the industrialized production. In addition, the target gene of the gene engineering strain is integrated into the chromosome, thus the gene engineering strain can not be lost during sub cultures, the genetic stability is high, and the production performance is stable.

The invention provides intelligent controlled-release drug-loaded bone cement and a preparation method and application thereof, and relates to the technical field of biomedical materials. The intelligent controlled-release drug-loaded bone cement comprises powder and liquid, wherein the liquid-solid ratio of the powder to the liquid is 1ml to (2-2.2)g. The powder comprises the following componentsin percentage by mass: 79.5+ / -1.0% of polymethyl methacrylate, 0.5+ / -0.1% of an initiator, 10.0+ / -1.0% of hollow polydopamine nanoparticles / antibiotic drug-loaded microspheres and 10.0+ / -1.0% of a developing agent. The problems of uncontrollable drug release, burst release and low drug embedding rate of microsphere carriers in an existing bone-cement-containing product are solved; the hollow polydopamine nanoparticle / antibiotic drug-loaded microspheres are added, so that the drug loading capacity is high and stable, and a drug is prevented from being released too early; the microspheres havethe pH responsiveness and can be used for controlled release of the drug according to the pH change; and in addition, the biological activity of the bone cement is promoted.