The invention relates to health-care wine and a preparation method thereof. The health-care wine is prepared from the following traditional Chinese medicine raw materials in parts by weight: 5-20 parts of ginseng, 1-10 parts of cornu cervi pantotrichum, 5-30 parts of broomrape, 5-30 parts of cornus officinalis sieb et zucc, 20-60 parts of longspur epimedium, 20-60 parts of polygonum multiflorum, 5-30 parts of fenugreek, 5-30 parts of cynomorium, 5-30 parts of milletia speciosa champ, 5-30 parts of philippine flemingia root, 1-20 parts of rhizoma curculiginis, 5-30 parts of rhizoma cibotii, 5-10 ursine seal testes and penis, 1-3 dog testes and penis, 5-10 ox testes and penis, 5-10 pairs of geckoes and other traditional Chinese medicines, wherein the proportion of the traditional Chinese medicine components to the wine is 1:(5-40). The health-care wine jointly prepared from dozens of specific medicinal materials has the effects of nourishing liver and kidney, replenishing essence and blood, strengthening bone and musculature, nourishing heart and spleen, replenishing essence, supplementing qi and promoting the production of body fluid, replenishing blood for nourishing heart, soothing the nerves and stabilizing the mind, improving hearing and vision, nourishing yin and tonifying yang, resisting aging, enhancing immunity, and the like. According to the preparation method of the health-care wine, the medicinal materials are stewed and placed into the wine with decoction together for soaking, so that the effective components contained in the medicinal materials are easily released during brewing, and the wine brewing time is shortened; the produced health-care wine is high in nutritional component content.