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Intelligent controlled-release drug-loaded bone cement and preparation method and application thereof

A bone cement and drug-loading technology, which is applied in the fields of pharmaceutical formulation, drug delivery, and medical science, can solve problems such as sudden release of drugs, "burst release of antibiotics, waste, etc., and achieve simple and easy preparation methods, prevent premature release, Improve the effect of biological activity

Pending Publication Date: 2020-10-02
BEIJING BONSCI TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] 1. The drug release is not complete enough, and the internal antibiotics cannot be released well, resulting in waste
[0005] 2. Drug release cannot be controlled on demand
[0006] 3. There is a phenomenon of "sudden drug release": after the implantation of the existing commercial antibiotic-containing bone cement, the phenomenon of "burst release" of antibiotics will occur at the initial stage of implantation, so a local high concentration environment of antibiotics will be formed in the early stage of implantation
For infections or inflammations that occur after a period of time after implantation, the initial large-scale release of antibiotics causes a waste of antibiotics, and then cannot achieve timely therapeutic effects. In severe cases, it may face the risk of secondary revision
[0007] In addition, the biological activity of PMMA bone cement loaded with antibiotics needs to be further improved

Method used

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  • Intelligent controlled-release drug-loaded bone cement and preparation method and application thereof
  • Intelligent controlled-release drug-loaded bone cement and preparation method and application thereof
  • Intelligent controlled-release drug-loaded bone cement and preparation method and application thereof

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preparation example Construction

[0091] According to the second aspect of the present invention, there is provided a method for preparing the above intelligent drug-loaded bone cement, comprising the following steps:

[0092] (a) preparing hollow polydopamine nanoparticles / antibiotic drug-loaded microspheres;

[0093] (b) mixing polymethyl methacrylate, initiator, hollow polydopamine nanoparticles / antibiotic drug-loaded microspheres and developer according to the proportioning ratio to obtain a powder;

[0094] (c) Intelligent drug-loaded bone cement composed of powder and liquid.

[0095] Further, step (a) comprises the following steps:

[0096] Dissolving the hollow polydopamine nanoparticles in buffer solution containing antibiotics to avoid light reaction, separating and washing to obtain hollow polydopamine nanoparticles / antibiotic drug-loaded microspheres;

[0097] Preferably, the antibiotic concentration in the buffer solution containing the antibiotic is 0.1-0.3%.

[0098] Taking gentamicin as an e...

Embodiment 1

[0116] An intelligent controlled-release drug-loaded bone cement includes powder and liquid; the liquid-solid ratio of the powder and liquid is 1(ml):2.12(g).

[0117] The powder comprises the following components in mass percentage: 79.5% of polymethyl methacrylate, 0.5% of benzoyl peroxide, 10.0% of hollow polydopamine nanoparticles / microspheres loaded with antibiotics, and 10.0% of barium sulfate.

[0118] The solution includes the following components in mass concentration: 98% of methyl methacrylate monomer, 2% of N,N-dimethyl-p-toluidine, and 70ppm of hydroquinone.

Embodiment 2

[0120] An intelligent controlled-release drug-loaded bone cement includes powder and liquid; the liquid-solid ratio of the powder and liquid is 1(ml):2.15(g).

[0121] The powder comprises the following components in mass percentage: 78.5% of polymethyl methacrylate, 0.6% of benzoyl peroxide, 11% of hollow polydopamine nanoparticles / microspheres loaded with antibiotics, and 9.9% of barium sulfate.

[0122] The solution includes the following components in mass concentration: 97.5% of methyl methacrylate monomer, 2.5% of N,N-dimethyl-p-toluidine, and 60 ppm of hydroquinone.

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Abstract

The invention provides intelligent controlled-release drug-loaded bone cement and a preparation method and application thereof, and relates to the technical field of biomedical materials. The intelligent controlled-release drug-loaded bone cement comprises powder and liquid, wherein the liquid-solid ratio of the powder to the liquid is 1ml to (2-2.2)g. The powder comprises the following componentsin percentage by mass: 79.5+ / -1.0% of polymethyl methacrylate, 0.5+ / -0.1% of an initiator, 10.0+ / -1.0% of hollow polydopamine nanoparticles / antibiotic drug-loaded microspheres and 10.0+ / -1.0% of a developing agent. The problems of uncontrollable drug release, burst release and low drug embedding rate of microsphere carriers in an existing bone-cement-containing product are solved; the hollow polydopamine nanoparticle / antibiotic drug-loaded microspheres are added, so that the drug loading capacity is high and stable, and a drug is prevented from being released too early; the microspheres havethe pH responsiveness and can be used for controlled release of the drug according to the pH change; and in addition, the biological activity of the bone cement is promoted.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to an intelligent controlled-release drug-loaded bone cement and its preparation method and application. Background technique [0002] PMMA bone cement (polymethyl methacrylic, polymethyl methacrylate) is a typical representative of bio-organic polymer bone cement materials. It has the characteristics of filling the gap between bone and prosthesis and has the characteristics of spontaneous solidification due to polymerization reaction. It is mainly used in artificial joint replacement surgery . Antibiotics are added to the bone cement to form a high-concentration antibiotic environment locally at the implantation site, thereby reducing postoperative infection or treating postoperative infection after artificial joint replacement. [0003] At present, the PMMA bone cement carrying antibiotics also has the following defects: [0004] 1. The drug release is not complete ...

Claims

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Application Information

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IPC IPC(8): A61L27/48A61L27/50A61L27/54A61L27/58
CPCA61L27/48A61L27/50A61L27/54A61L27/58A61L2300/406A61L2300/624A61L2430/02C08L33/10
Inventor 聂洪涛张凯张洪玮
Owner BEIJING BONSCI TECH CO LTD
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