45results about How to "Avoid premature release" patented technology

Nanocapsules are disclosed which comprise (a) a drug-containing core and (b) a polyelectrolyte multilayer encapsulating the drug-containing core. The nanocapsules include particles whose largest dimension typically ranges between 50 nm to 10000 nm. In some embodiments, the nanocapsules contain a single drug. In others, the nanocapsules contain multiple drugs, either within the same nanocapsules or within separate populations of nanocapsules. In some embodiments, the nanocapsules comprise surfaces that are functionalized, for example, with ligands that allow for attachment to bodily tissue. In some embodiments of the present invention, the nanocapsules are rendered magnetic or are rendered susceptible to magnetic fields. Also disclosed is a drug delivery method that comprises the steps of (a) providing nanocapsules such as those above; and (b) placing the nanocapsules at a desired location within the body of a subject using an implantable or insertable medical device.

The present invention relates to a tissue clamp, a tool for grasping the clamp and a method of using the clamp for surgical procedures. The clamp has a fixture or fixtures positioned on the proximal end of the arms of the clamp so that a tool can be used by the surgeon to securely grasp the clamp during placement thereof on the vasculature or other tissue of the patient. The fixture can have a plurality of channels so that the user can select the angular orientation of the tool relative to the damp.

A simple, disposable sensing device for sensing an analyte is housed in a single case. The sensing device can transmit sensor data to monitoring device(s). The sensing device includes: a case having a lower major wall adapted to be mounted against a patient's skin, and an upper opposing major wall; a sensor extending from the case and having a distal end sensitive to the analyte to produce an electrical signal, and a proximal end within the case having electrical contacts; a printed circuit board assembly within the case supported by one of the major walls to receive the electrical signal via the electrical contacts; and an elastomeric pad disposed in the case and biased by the other major wall to urge the proximal end of the sensor into contact with the printed circuit board assembly and maintain an electrical connection between the electrical contacts and the printed circuit board assembly.

A polymeric, surgical clip having first and second curved leg members joined at their proximal end by a hinge portion and movable from an open position to a closed position for clamping a vessel between curved opposing inner surfaces which are substantially parallel when the clip is closed. An interlocking mechanism is formed by a portion of the inner surfaces of the first and second legs. The interlocking mechanism may be a tongue-in-groove mechanism, formed by a lip or tongue protruding from a portion of the inner surface of one leg and a groove formed in a corresponding portion of the inner surface of the other leg, or a lock-step mechanism, formed by complementary L-shaped notches wherein a notch is provided in a portion of the inner surface of each leg. The interlocking mechanism acts to impede longitudinal movement of the clip relative to the vessel being clamped.

A polymeric, surgical clip having first and second curved leg members joined at their proximal end by a hinge portion and movable from an open position to a closed position for securing and maintaining a desired amount of tension on a suture. A ridge protrudes from a portion of the inner surface of one leg and a groove is formed in a corresponding portion of the inner surface of the other leg. An eyelet extends through the ridge to engage a portion of a suture.

The invention relates to the preparation of a rubber composition containing starch / plasticizer composite reinforcement, together with at least one additional reinforcing filler, through the utilization of a combination of an organosilane disulfide compound mixed with a rubber composition in a preparatory, non-productive, mixing stage(s) followed by adding an organosilane polysulfide compound in a subsequent, productive, mixing stage. The invention further relates to the resulting rubber composition and use thereof in rubber products, including tires.

The invention discloses thermosensitive hydrogel loaded with copper metal organic skeleton nanoparticles and a preparation method of the thermosensitive hydrogel. The preparation method comprises thesteps that an amino group on gelatin and methacrylic anhydride are subjected to acylation reaction to synthesize methylacrylic esterified gelatin with a branch containing a carbon-carbon double bond,the carbon-carbon double bond on the branch and N-isopropyl acrylamide are subjected to free radical polymerization, and methylacrylic esterified gelatin-g-poly N-isopropyl acrylamide is prepared; 1,3,5-benzene tricarbonic acid and copper acetate monohydrate are used for preparing copper-based MOF nanoparticles; the copper-based MOF nanoparticles are added to a methylacrylic esterified gelatin-g-poly N-isopropyl acrylamide solution, and a product is prepared. Copper ions are embedded in the biodegradable thermosensitive hydrogel in the form of HKUST-1 NPs, controlled slow release of the copperions is achieved, cytotoxicity is effectively reduced, migration of in-vitro dermal cells is promoted, angiogenesis is induced, and wound healing is promoted.

An apparatus useful for preventing the release of residual liquid in a beverage brewing device prior to and after the brewing process, and for preventing the premature release of liquid during the heating process is disclosed. The apparatus includes a flexible member, a closing member and a recess. The apparatus is fabricated such that the pressure of the liquid being delivered to the brewing chamber displaces or depresses the closing member sufficiently into the recess to form a first fluid passage. The pressure of the fluid also creates a channel or cavity on a surface of the flexible member. The first fluid passage and the channel or cavity form a second fluid passages which provide fluid communication between the fluid inlet and the brewing chamber. Preferably, the flexible member, closing member and recess is formed as an integral unit.

The pick-up device provides an elongated hollow cylindrical body including a handle at one end and a bail arrangement at the other end. The handle includes a trigger mechanism extending through the hollow body and terminating in a crank coupling the pair of bails in the bail assembly, so that one bail is fixed and the other bail is movable with respect to the fixed bail. The body includes a roller upon which a supply of litter bags is placed, and the body includes an elongated slot with finger openings so that a single bag from the supply can be withdrawn from the roll, separated from the roll, and installed on the pair of bails in the bail arrangement. A cable is employed for releasably actuating the bail and mechanism is provided for rotatably mounting the handle and trigger mechanism onto one end of the body so that the handle can be rotated as to expose the aft end of the body permitting a new roll of bags to be installed. Alternately, a bag supply cartridge may be installed through the side of the body.

A toothbrush holder includes an outer body with a bottom section coupled thereto. A seal is intercalated therebetween and extends along the circumference of the outer body. An inner body is seated within the outer body and includes a plurality of chambers equidistantly aligned with a center thereof. The inner body has a diameter less than a diameter of the outer body and has a vertically oriented central shaft formed with the chambers. A top plate is attached to the chambers and is provided with a plurality of apertures counter-sunk therein and vertically aligned above the chambers. A dome-shaped lid is connected to an outer perimeter of the outer body, and disposed adjacent to the top plate. The apparatus includes a mechanism for automatically locking the lid to the outer body after the lid is adapted to a closed position.

The invention relates to a polypeptide-protein-drug-carried solid particulate matter and a double-enteric solid preparation containing the same, and preparing methods and application of the polypeptide-protein-drug-carried solid particulate matter and the double-enteric solid preparation. The solid particulate matter contains polypeptide protein drugs, absorption enhancers and protease inhibitors.The prepared double-enteric solid preparation can resist degradation of gastric acid and gastric intestinal enzymes to the polypeptide protein drugs during oral administration and meanwhile has the colon-specific effect, and absorption of polypeptide proteins in an intestinal tract can be effectively promoted.

The present invention relates to a device (1) for producing electrical energy from the exhaust gas of an internal combustion engine (2), comprising a generator (3) with an exhaust gas inlet nozzle (4) and an exhaust gas exit nozzle (5) and at least one heat exchange section (6) therebetween, wherein at least one flow diverter (7) and flow distributor (8) is provided between the exhaust gas inlet nozzle (4) and the heat exchange section (6), and furthermore the heat exchange section (6) is designed with a plurality of flow paths (9) perpendicular to the exhaust gas inlet nozzle (4), said pathsable to be assigned to a plurality of heat exchange assemblies (10), wherein furthermore at least a section of the heat exchange assembly (10) is designed with at least one thermoelectric element (11) and one cooling device (12) and the at least one thermoelectric element (11) is connected to the cooling device (12) undetachably.

The invention discloses a copper metal organic framework nanoparticle functionalized hydrogel, a preparation method and application thereof. The preparation method comprises the following steps: dissolving carboxymethyl chitosan, and adding reduced glutathione and N-hydroxysuccinimide which are mixed and dissolved in deionized water; adding 1-(3-dimethylaminopropyl)-3-ethyl carbodiimide hydrochloride to prepare glutathione modified carboxymethyl chitosan; preparing copper metal organic framework nanoparticles; then mixing the copper metal organic framework nanoparticles with deionized water; and adding the glutathione modified carboxymethyl chitosan, acrylamide, polyethylene glycol diacrylate, polyethylene glycol diglycidyl ether and an initiator to prepare the copper metal organic framework functionalized hydrogel. According to the invention, the obtained hydrogel has the capabilities of slowly and controllably releasing copper ions, removing active oxygen of a wound surface, always keeping the wound surface free of hydrops and a wet 3D microenvironment, protecting the wound from external injury and promoting wound healing.

A hand-held setting tool (10) includes a connection element (16) for connecting the setting tool (10) with a positioning device (20) having an actuation element (24), a switching link (30) for connecting the actuation element (24) to the actuation switch (13) of the setting tool (10) and having a first switching element (34) axially displaceable relative in a structural component (33), and a safety device (50) for preventing actuation of the actuation switch (13) at an orientation of the setting tool (10) other than a predetermined orientation and including at least three blocking members (55a, 55b, 55c) displaceable in at least three separate channels (56) respectively, and receivable in a recess (51) formed in the first, switching element (34) and opening toward the structural component, with the channels (56) being inclined with respect to a plane (E) extending perpendicular to a longitudinal axis (A), of the positioning device, and with at least three channels (56) intersecting, in some regions, an axial projection of the switching element (34) in form of a secant and opening toward the first, switching element (34) in respective overlapping regions (59).

The invention discloses a knitting support capable of being completely recycled. The knitting support comprises a support body of a tubular structure as a body for supporting a blood vessel, a pushing recycling device and a cutting component. The body comprises a cutting component and a knitting component, the cutting component is close to the near end of the support, and the knitting component is close to the far end of the support; the push recycling device is detachably connected with the support body for pushing and recycling the support body inside a guide pipe, the near end of the cutting component is connected with the pushing recycling device, and the far end of the cutting component is connected with the knitting component, wherein a crossing hole is formed in the cutting component for crossing and knitting knitted wires of the knitting component. The knitting support capable of being completely recycled has the advantages that compared with the prior art, after the knitting support is completely released, if the problems that positioning of the support is not accurate and wall adhesion is poor appear, the support can be recycled into a micro guide pipe and positioned and released again, and therefore operation safety is ensured.

Improved formulations that combine chemical permeation enhancers with additional agents so that the formulations simultaneously penetrate both lipid and cellular matrices provide effective transdermal delivery of active agents.