524 results about "Disulfide compound" patented technology

New thiol and disulfide-containing maytansinoids bearing a mono or di-alkyl substitution on the α-carbon atom bearing the sulfur atom are disclosed. Also disclosed are methods for the synthesis of these new maytansinoids and methods for the linkage of these new maytansinoids to cell-binding agents. The maytansinoid-cell-binding agent conjugates are useful as therapeutic agents, which are delivered specifically to target cells and are cytotoxic. These conjugates display vastly improved therapeutic efficacy in animal tumor models compared to the previously described agents.

The invention relates to the preparation of a rubber composition containing starch/plasticizer composite reinforcement, together with at least one additional reinforcing filler, through the utilization of a combination of an organosilane disulfide compound mixed with a rubber composition in a preparatory, non-productive, mixing stage(s) followed by adding an organosilane polysulfide compound in a subsequent, productive, mixing stage. The invention further relates to the resulting rubber composition and use thereof in rubber products, including tires.

A transparent, non elastomeric, high index, impact resistant polythiourethane/urea material comprising the reaction product of: a) at least one (alpha, omega)-diiso(thio)cyanate cycloaliphatic or aromatic prepolymer having a number average molecular weight ranging from 100 to 3000 gmol-1, and b) at least one primary diamine, in an equivalent molar ratio amine function/iso(thio)cyanate function from 0.5 to 2, preferably from 0.90 to 1.10, wherein, said prepolymer and diamine are free from disulfide (-S-S-) linkage and at least one of the prepolymer or the diamine contains one or more S atoms in its chain.

This invention discloses a method for preparing rubber compositions that exhibit unique combinations of properties that are desirable for tire tread applications for enhanced snow/ice and wet traction, low rolling resistance and increased treadwear performance in comparison with conventional silica compounds. Specifically, a high reactively silane coupling agent, such as a mercaptosilane, is used in combination with a silane coupling typically used for silica tread compounds such as bis(triethoxylsilylpropyl)disulfide to treat silica pellets in a hydrocarbon solvent at elevated temperatures. The treated silica is then blended with solution elastomer cement in a hydrocarbon solvent. The deposited reactive silanes partially react with the elastomer molecules forming a layer of polymer grafted on the silica surfaced. This structure significantly improves the silica retention during the steam stripping operation. Almost 100% (99+%) silica retention has been achieved by this invention. After solvent removal from steam stripping, the treated silica/elastomer mixer is dewatered and dried using conventional equipment such as shaker screens, expellers and expanders to form a well-dispersed silica masterbatch. This technique results in silica compounds with excellent silica dispersion and increased filler-polymer interaction, hence enhanced compound performance such as better physical properties, more desirable dynamic properties (low hysteresis at high temperatures and high hysteresis at low temperatures) and increased abrasion resistance.

An activator composition for the accelerated hardening of cyanoacrylate adhesives, wherein the activator comprises a member selected from the group consisting of: aromatic heterocyclic compounds having at least one N hetero atom in the ring(s) such as pyridines, quinolines and pyrimidines and substituted on the ring(s) with at least one electron-withdrawing group which decreases the base strength of the substituted compound compared to the corresponding unsubstituted compound, mixtures of any of the foregoing with each other, and/or with N,N-dimethyl-p-toluidine, and mixtures of any of the foregoing and/or N,N-dimethyl-p-toluidine with an organic compound containing the structural element, —N═C—S—S—, such as dibenzothiazyl disulfide. 6,6′dithiodinicotinic acid, 2,2′-dipyridyl disulfide, and bis(4-t-butyl-1-isopropyl-2-imidazolyl)disulfide. An activator composition may comprise a solution of one or more activators in a solvent mixture which comprises a volatile hydrocarbon and a cyclic ketone.

The invention relates to the preparation of a rubber composition containing silica-based filler reinforcement through the utilization of a organosilane disulfide compound mixed with a rubber composition in at least one preparatory, non-productive, mixing stage followed by utilization of an organosilane polysulfide compound mixed with the rubber composition in a subsequent, productive, mixing stage. The invention further relates to the resulting rubber composition and use thereof in tires.

The invention provides the compounds of formula (I) or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutical compositions comprising one or more compounds of formula (I) or intermediates thereof and one more of pharmaceutically acceptable carriers, vehicles or diluents. The invention further provides methods of preparation and methods of use of prodrugs including NO-releasing prodrugs, double prodrugs and mutual prodrugs comprising the compounds of formula (I).

A curable composition containing an inorganic compound A having sulfur atom and/or selenium atom, a compound B represented by the following formula 1:

wherein m is an integer from 0 to 4, and n is an integer from 0 to 2,

and a compound C selected from the group consisting of thiol compounds having one SH group and disulfide compounds which are other than the compound B and have one or more disulfide linkages. The inorganic compound A is contained in an amount from 1 to 50 parts by weight and the compound B is contained in an amount from 50 to 99 parts by weight when a total of the inorganic compound A and the compound B is taken as 100 parts by weight. The compound C is contained in an amount from 1 to 20 parts by weight based on 100 parts by weight in total of the inorganic compound A and the compound B. The curable composition causes little increase in the viscosity even when subjected to prepolymerization and deaeration, thereby facilitating the operation of cast polymerization for producing optical materials, etc.

Prodrugs containing lipid moieties attached to drug derivatives, such as anti-cancer drug derivatives, via linkers comprising disulfide groups are described. Also described are nanoparticles coated with a lipid layer containing the prodrugs, formulations comprising the nanoparticles, and the use of the nanoparticles in methods of treating diseases, such as cancer, alone or in combination with additional drug compounds, targeting agents, and/or immunotherapy agents, such as immunosuppression inhibitors that target the CTLA-4, PD-1/PD-L1, IDO, LAG-3, CCR-7 or other pathways, or multiple immunosuppression inhibitors targeting a combination of such pathways. Optionally, the nanoparticles can comprise a photosensitizer or a derivative thereof and can be used in methods involving photodynamic therapy. Synergistic therapeutic effects result from combinations of multiple modalities provided by the disclosed nanoparticles and/or nanoparticle formulations.

A granular polyarylene sulfide; (i) the granular polyarylene sulfide containing an —S— substituent at the terminal, the substituent being formed by cleavage of a disulfide compound; (ii) the granular polyarylene sulfide being an oversize fraction after sifting with a sieve having a mesh size of at least 38 μm; (iii) the granular polyarylene sulfide having a halogen content of at most 1,500 ppm; and (iv) the granular polyarylene sulfide being a granular polyarylene sulfide having a melt viscosity of 3 to 100 Pa·s when measured under conditions at a temperature of 310° C. and a shear rate of 1,200 sec⁻¹. The granular polyarylene sulfide is well balanced in melt viscosity, halogen content, nitrogen content, thermal stability, and yield.

The invention relates to application of a disulfide compound in crop protection. The invention discloses application of the disulfide compound shown by a structural formula (I) in serving as a plant growth regulator, a soil disinfectant or a pesticide synergist, wherein R1 and R2 independently represent C1-C6 alkyl, C3-C6 cycloalkyl, C2-C6 alkenyl, phenyl, tolyl, benzyl, fnrfuryl and furyl respectively. The disulfide compound can promote the growth and the development of plants, promote the formation of flower buds, improve the fruiting rate, protect fruit growth, improve the yield and the quality, kill bacteria, fungi, viruses and nematodes which are harmful to crops in soil, and reduce the using frequency or the dosage of insecticidal and acaricidal agricultural chemicals. 1 to 90 percent of the disulfide compound in percentage by weight and an agriculturally acceptable auxiliary agent are prepared into wettable powder, emulsions, sprayable solutions, concentrated emulsions, aerosols and seed coatings, and are sprayed after being diluted properly, irrigated to roots or splashed to leaf surfaces, stems, fruits or seeds of crops and soil, thus the disulfide compound is a multifunctional green pesticide.

The invention belongs to the technical field of functional materials and particularly relates to intelligent aerogel with dual responses and adjustable response behaviors and a preparation method thereof. Transition metal disulfide compound powder is ultrasonically stripped through a natural polymer water phase, a nanosheet layer of a polymer non-covalent bond modified transition metal disulfide compound is obtained, temperature-sensitive monomers and other comonomers and crosslinking agents are added to further prepare the composite aerogel of the disulfide compound nanosheet layer. The composite aerogel has excellent mechanical performance and has dual response characteristics of the far infrared response and the temperature response, and the response behaviors can be customized and adjusted. The related raw materials are natural polymers and other non-toxic and harmless reagents, water serves as an adopted solvent, the preparation process is environmentally friendly and free of pollution, operation is easy and convenient, the production cost is low, the intelligent aerogel is expected to be industrially produced on a large scale, and the prepared intelligent aerogel has multiple functions and has potential for large-scale preparation and wide commercial application prospects.

A method of increasing the discharge capacity retention of a non-aqueous lithium ion secondary battery having a positive electrode active material, a combination of a lithium element and a complex metal oxide, a negative electrode, and a non-aqueous electrolytic solution comprising an electrolyte dissolved in a non-aqueous solvent which is a combination of a cyclic carbonate and a linear carbonate by incorporating a disulfide derivative having the formula:

R¹—S—S—R²

wherein each of R¹ and R² independently represents a phenyl group, a benzyl group, a tolyl group, a pyridyl group, a pyrimidyl group, an alkyl group having 1 to 12 carbon atom, or a cycloalkyl group having 3 to 6 carbon atoms, in which each group has no substituent groups or has one or more alkyl groups into the non-aqueous electrolytic solution.