1521 results about "Natural polymers" patented technology

The present invention relates to an abuse-proofed, thermoformed dosage form containing, in addition to one or more active ingredients with abuse potential optionally together with physiologically acceptable auxiliary substances, at least one synthetic or natural polymer with a breaking strength of at least 500 N and to a process for the production thereof.

The invention relates to a dosage form that is thermoformed without discoloration and is safeguarded from abuse, comprising at least one synthetic or natural polymer having a breaking strength of at least 500 N in addition to one or more active substances that could be subject to abuse. The invention also relates to a corresponding method for producing said dosage form.

The invention relates to a dosage form comprising a physiologically effective amount of a physiologically active substance (A), a synthetic, semi-synthetic or natural polymer (C), optionally one or more physiologically acceptable auxiliary substances (B) and optionally a synthetic, semi-synthetic or natural wax (D), wherein the dosage form exhibits a resistance to crushing of at least 400 N and wherein under physiological conditions the release of the physiologically active substances (A) from the dosage form is at least partially delayed.

The present invention relates to a process for the production of an abuse-proofed solid dosage form containing at least one active ingredient with potential for abuse and a synthetic or natural polymer with a breaking strength of =500 N, characterized in that a corresponding mixture is processed by melt extrusion with the assistance of a planetary-gear extruder.

The invention discloses nano-silver antibacterial hydrogel and a preparation method thereof, wherein the antibacterial hydrogel does not contain a chemical cross-linking agent, a cross-linking sensitizing agent and a cross-linking initiator; the porosity is above 90%; the cross-linking degree is above 50%; by weight, the nano-silver antibacterial hydrogel comprises 3-20% of natural polymer or a derivative thereof, 0-20% of synthetic polymer and 0..005-0.2% of nano-silver; and the nano-silver antibacterial hydrogel is prepared by blending the natural polymer or the derivative thereof, the synthetic polymer, a compound containing silver ions and water and then adopting a radiation cross-linking method. The nano-silver antibacterial hydrogel disclosed by the utility model has good biocompatibility and uniform nano-silver distribution and slow-release capability and is capable of effectively inhibiting bacteria, such as escherichia coli.

The invention relates to a method for preparing shell-core structured medicament nano fiber by coaxial electrostatic spinning technology, comprising: (1) dissolving high molecular polymer and medicament in mass proportion of 60-99.9:0.1-40 in organic solvent with high volatility, and stirring until complete dissolution to obtain shell solution; (2) dissolving one or more than one of natural polymer, medicament, and bioactive factor in the solvent, or dissolving the same in super pure water under aseptic condition to obtain core solution; and (3) carrying out coaxial electrostatic spinning, setting the spinning voltage at 15-25kv, the reception distance at 8-20cm, the spinning pushing speed at 0.1-1.5mL/h, and the spinning nozzle as 0.9mm, to obtain the shell-core structured medicament nano fiber. The preparation method is simple in operation, mild in reaction condition, low in cost and favorable for economic benefit; in preparing the shell-core structured medicament nano fiber, two or more than two medicaments can be simultaneously loaded and released, thus meeting requirements of tissue regeneration or patients.

The invention discloses a composite natural polymer gel material with a cross-linking agent. The material comprises hydrogel, organogel, aerogel and bioplastics and mainly overcomes the problem of low mechanical strength of conventional natural polymer gel materials. According to the invention, a certain amount of the cross-linking agent is added into a natural polymer water-based solution or dispersion liquid, then stirring is carried out, the obtained mixture is placed in a non-solvent for physical cross-linking, and then washing is carried out so as to obtain composite natural polymer hydrogel; water in the composite natural polymer hydrogel is replaced with an organic solution so as to prepare composite natural polymer organogel; the composite natural polymer hydrogel or organogel is dried so as to prepare composite natural polymer aerogel; the composite natural polymer aerogel is subjected to hydrophobic treatment so as to obtain hydrophobic aerogel; the composite natural polymer aerogel is subjected to heat treatment so as to obtain carbon aerogel; and one or more selected from the above-mentioned gel materials are subjected to high-temperature pressing so as to prepare composite natural polymer bioplastics. The composite natural polymer gel material prepared in the invention has the advantages of excellent mechanical properties, a high specific surface area, high elongation at break, etc., and can be easily processed into molded products of a plurality of forms.

The invention discloses a blumea oil microcapsule textile composite finishing agent and use thereof. Gelatin or acacia of natural polymers is used the main ingredient of a wall material, the blumea oil serving as a Chinese medicinal material is used as a core material, and complex coacervation is adopted to prepare an blumea oil microcapsule aqueous emulsion; a shrink-resistance crosslinker and a catalyst are added to be combined with the blumea oil microcapsule aqueous emulsion into a multifunctional blumea oil microcapsule textile composite finishing agent; researches on the use of blumea oil microcapsules in textile finishing are carried out; and a novel cross linked graft method is used to perform the microcapsule finishing of textiles to form chemical bonds between the microcapsules and the textiles though the shrink-resistance crosslinker and free formaldehyde molecules in 2D resin further participate in a cross-linking and curing reaction as a microcapsule curing agent, so the textiles achieve a long lasting antibacterial and health-care function, a shrink-resistance function and low formaldehyde release content performance.

A biodegradable packaging film is provided. The film is formed from a blend that contains a thermoplastic starch and polylactic acid. Starch is a relatively inexpensive natural polymer that is also renewable and biodegradable. Polylactic acid is likewise an inexpensive synthetic polymer that is biodegradable and renewable, yet also capable of providing increased tensile strength to the film. Although providing a good combination of biodegradability/renewability and increased tensile strength, the polylactic acid is also relatively rigid and can result in films having a relatively high stiffness (e.g., high modulus of elasticity) and low ductility. While more ductile than polylactic acid, the thermoplastic starch is often difficult to melt process in film forming processes and very sensitive to moisture and water vapor, reducing its ability to be used as a stand alone packaging film. In an effort to counteract the effect of such polymers, an aliphatic-aromatic copolyester is also employed in the blend of the present invention. While such copolyesters are biodegradable, they also possess the melt properties and ductility that lend them well to the formation of films. Although the combination of these polymers may achieve a good balance between biodegradability/renewability, high tensile strength, and good ductility (e.g., high peak elongation), it is still often difficult to achieve a precise set of mechanical properties as desired for packaging films. In this regard, the blend also contains a filler. Due to its rigid nature, the amount of the filler may be readily adjusted to fine tune the blend to the desired degree of ductility (e.g., peak elongation) and stiffness (e.g., modulus of elasticity).

Natural fiber welding is a process by which individual fibers are swollen by an appropriate ionic liquid-based solvent system to form a congealed network. Manipulated fibrous materials may be either composed of natural polymers such as cellulose, hemicellulose, silk, et cetera, or synthetic polymers, or mixed materials. The process is principally controlled by the composition of the solvent system which includes an ionic liquid solvent plus additives such as water, methanol, et cetera. Other conditions such as the amount and placement of solvent, as well as time, temperature, and pressure control the extent to which neighboring fibers are fused. Only the material at the outer surface of fibers need be sufficiently mobile to merge with that of neighboring fibers. Material in the fiber core may be left in the native state by controlling process variables. Fibers form a congealed network upon removal of the ionic liquid-based solvent.

Biodegradable polymer blends suitable for laminate coatings, wraps and other packaging materials are manufactured from at least one "hard" biopolymer and at least one "soft" biopolymer. "Hard" biopolymers tend to be more brittle and rigid and typically have a glass transition temperature greater than about 10° C. "Soft" biopolymers tend to be more flexible and pliable and typically have a glass transition temperature less than about 0° C. While hard and soft polymers each possess certain intrinsic benefits, certain blends of hard and soft polymers have been discovered which possess synergistic properties superior to those of either hard or soft polymers by themselves. Biodegradable polymers include polyesters, polyesteramides, polyesterurethanes, thermoplastic starch, and other natural polymers. The polymer blends may optionally include an inorganic filler. Films and sheets made from the polymer blends may be textured so as to increase the bulk hand feel. Wraps will typically be manufactured to have good "dead-fold" properties so as to remain in a wrapped position and not spring back to an "unwrapped" form.

Biodegradable polymer blends suitable for laminate coatings, wraps and other packaging materials are manufactured from a blend of suitable biodegradable polymers, such as at least one “hard” biopolymer and at least one “soft” biopolymer. “Hard” biopolymers tend to be more brittle and rigid and typically have a glass transition temperature greater than about 10° C. “Soft” biopolymers tend to be more flexible and pliable and typically have a glass transition temperature less than about 0° C. While hard and soft polymers each possess certain intrinsic benefits, certain blends of hard and soft polymers have been discovered which possess synergistic properties superior to those of either hard or soft polymers by themselves. Biodegradable polymers include polyesters, polyesteramides, polyesterurethanes, thermoplastic starch, and other natural polymers. The polymer blends may optionally include an inorganic filler. Films and sheets made from the polymer blends may be textured so as to increase the bulk hand feel. Wraps will typically be manufactured to have good “dead-fold” properties so as to remain in a wrapped position and not spring back to an “unwrapped” form.

Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The present invention provides methods, compositions, and systems for synthesizing, selecting, amplifying, and evolving non-natural molecules based on nucleic acid templates. The sequence of a nucleic acid template is used to direct the synthesis of non-natural molecules such as unnatural polymers and small molecules. Using this method combinatorial libraries of these molecules can be prepared and screened. Upon selection of a molecule, its encoding nucleic acid template may be amplified and/or evolved to yield the same molecule or related molecules for re-screening. The inventive methods and compositions of the present invention allow for the amplification and evolution of non-natural molecules in a manner analogous to the amplification of natural biopolymer such as polynucleotides and protein.

The invention relates to a tissue engineering material and a preparation method thereof, in particular to a nano fiber tissue engineering blood vessel and a preparation method thereof. The invention consists of a three-dimensional reticular non-woven film formed by an inner layer of nano fiber and an outer layer of nano fiber; the inner layer of the blood vessel is natural polymer, wherein, calculated by weight, 40 percent to 80 percent is fibroin, 20 percent to 50 percent is gelatine, 0 percent to 20 percent is extracellular matrix protein; while the outer layer of the blood vessel is synthetic polymer. The preparation method is that the natural polymer is dissolved in trifluroroethyl and other solution, while the synthetic polymer is dissolved in hexafluoroisopropanol and other solution, which are respectively prepared into spinning solution; the static electricity spinning technique is adopted to subsequently form the inner and the outer layers on a gather roller; cross-linked treatment is conducted after the inner and the outer layers are taken down, to prepare the nano fiber tissue engineering vessel. The inner layer can simulate the structure of the extracellular matrix, provide good environment for endothelial cells to grow, support adhesion, proliferation and differentiation of the cells, and is good for endothelization of the blood vessel; and the outer layer has good mechanical performance.

The present invention relates to a process for the production of an abuse-proofed dosage form containing, apart from one or more active ingredients with potential for abuse and optionally physiologically acceptable auxiliary substances, at least one synthetic or natural polymer (C) with a breaking strength of at least 500 N, wherein the formulation mixture is combined with a solvent for the polymer (C) at least in quantities such that the formulation mixture is at least uniformly moistened, the at least moistened composition is optionally divided into sub-portions, dried and shaped to yield the dosage form.

The invention relates to a deformable plugging and anti-sloughing agent for drilling fluid, and the deformable plugging and anti-sloughing agent comprises 10-90 parts by weight of non-deformable material, 20-80 parts by weight of nano-scale deformable redispersible polymer and 10-60 parts by weight of natural polymer modified material. The invention further relates to a preparation method of the deformable plugging and anti-sloughing agent for the drilling fluid. The preparation method comprises the following steps: mixing all the components according to the corresponding mixture ratio, mixing by virtue of a mixing and stirring machine for 80-120 minutes and screening by virtue of a 100-300 mesh screen, thus obtaining the deformable plugging and anti-sloughing agent.