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Preparation method and application of polycaprolactone/natural polymer composite porous scaffold

A technology of natural macromolecules and polycaprolactone is applied in the field of preparation of medical porous stents, which can solve the problems of unsatisfactory histocompatibility and cell affinity, and achieve the effect of being beneficial to spreading and improving hydrophilicity.

Inactive Publication Date: 2011-12-14
NANCHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, compared with natural biomaterials, its histocompatibility and cell affinity cannot meet the needs of rapid development in tissue engineering and other biomedical fields.

Method used

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  • Preparation method and application of polycaprolactone/natural polymer composite porous scaffold
  • Preparation method and application of polycaprolactone/natural polymer composite porous scaffold
  • Preparation method and application of polycaprolactone/natural polymer composite porous scaffold

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] In this embodiment, NaOH is selected to treat the modified polycaprolactone electrospun nanofiber membrane, type gelatin, and coat the gelatin solution. The crosslinking agent is a mixture of EDC / NHS for crosslinking. The specific steps are as follows:

[0051] The first step, the preparation of polycaprolactone electrospun nanofiber membrane: Dissolve PCL in methanol / chloroform mixed solvent with a volume ratio of 1 / 1 to prepare an electrospinning solution with a concentration of 12 wt%, and fill the solution with In the feeding device of the electrospinning equipment, the feeding rate of the solution is set to 20 l / min, the acceptance distance is 8 cm, and the electrostatic voltage is 15 kV, the biodegradable ultrafine electrospun nanofiber membrane can be obtained (attached figure 1 ).

[0052] In the second step, the surface of polycaprolactone electrospun nanofiber membrane is modified by alkali treatment: the polycaprolactone electrospun nanofiber membrane is pla...

Embodiment 2

[0057] In this embodiment, the KOH-treated modified polycaprolactone electrospun nanofiber membrane is selected, the mixed solution of water-soluble chitosan, coated gelatin and chitosan is input, and the cross-linking agent is a mixture of EDC / NHS. Specific steps are as follows:

[0058] The first step, the preparation of polycaprolactone electrospun nanofiber membrane: dissolve PCL in DMF / chloroform with a volume ratio of 3 / 2 to prepare an electrospinning solution with a concentration of 18 wt%, and put the solution into the electrospinning In the feeding device of silk equipment, set the feeding rate of the solution to 20 l / min, the acceptance distance is 8 cm, and the electrostatic voltage is 15 kV, the biodegradable ultrafine electrospun nanofiber membrane can be obtained.

[0059] In the second step, the polycaprolactone electrospun nanofiber membrane is subjected to surface alkali treatment modification: the polycaprolactone electrospun nanofiber membrane is placed ...

Embodiment 3

[0064] In this embodiment, NaOH is selected to treat the modified polycaprolactone electrospun nanofiber membrane, gelatin is added, gelatin and sodium alginate mixed solution are coated, and the dehydrating agent is selected from a mixture of EDC / NHS for crosslinking. The specific steps are as follows:

[0065] The first step, the preparation of polycaprolactone electrospun nanofiber membrane: Dissolve PCL in methanol / chloroform mixed solvent with a volume ratio of 1 / 1 to prepare an electrospinning solution with a concentration of 15 wt%, and fill the solution with In the feeding device of the electrospinning equipment, the feeding rate of the solution is set to 20 l / min, the acceptance distance is 8 cm, and the electrostatic voltage is 15 kV, the biodegradable ultrafine electrospun nanofiber membrane can be obtained.

[0066] In the second step, the polycaprolactone electrospun nanofiber membrane is modified by surface alkali treatment: the polycaprolactone electrospun nano...

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Abstract

Preparation method and application of polycaprolactone / natural polymer composite porous scaffold, method: including preparation of polycaprolactone electrospun nanofiber membrane; (1) placing polycaprolactone electrospun nanofiber membrane in alkaline solution reaction, soaking and rinsing in deionized water; (2) putting the fiber membrane obtained in (1) into DMTMM or natural polymer solution of DTMMM to react, immersing and rinsing in deionized water, and then immersing in natural polymer for room temperature reaction, to remove Ionized water soaking and rinsing; (3) Evenly coating and casting the mixed solution of natural polymer materials on the fiber membrane obtained in (2), freeze-drying, and extracting the solvent; (4) Applying the double-layer scaffold obtained in (3) After soaking in the cross-linking room temperature reaction, soaking in deionized water, rinsing, and freeze-drying. The porous scaffold prepared by the invention is stable, has suitable pore diameter, good biocompatibility and fast degradation rate, and can be used for skin and clinical tissue and organ defect repair, reconstruction or wound dressing.

Description

technical field [0001] The invention belongs to the field of medical porous bracket materials, and relates to a preparation method and application of a medical porous bracket. Background technique [0002] With the continuous development of nanofiber preparation technology, the nano-nonwoven fabric prepared by the electrostatic spraying method is a geometric space composed of randomly oriented nanofibers, and has an extracellular matrix structure imitating the nano-scale collagen in the body. The large surface area makes it a good scaffold material. Its preparation process is simple, the fiber mesh is light and soft, and it is convenient for operation; when it is implanted in the body, it can reduce the hardness mismatch with the body's own tissue, and a very small amount of polymer will reduce the side effects of implanted materials; and its great The specific surface area and surface area to volume ratio, high porosity and microporous structure on the fiber surface endow ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D06M13/358D06M15/01C08J9/28C08J3/24B32B5/18A61L27/18A61L27/34A61L15/26A61L15/28A61L15/32D06M101/32
Inventor 陈义旺周志华聂华荣汪泱周魏华李璠
Owner NANCHANG UNIV
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