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Method for preparing sodium alginate-chitosan nano-grade medical dressing

A technology of chitosan nanometer and sodium alginate, which is applied in medical science, conjugated synthetic polymer artificial filament, conjugated artificial filament, etc., can solve the problems of damage to new tissue and iatrogenic pollution, and achieve accelerated Effects of healing, growth and regeneration, and low cost

Active Publication Date: 2014-10-01
江苏开源康达医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many inconveniences in the use of medical dressings. Some dressings use non-degradable materials as scaffold materials, causing iatrogenic pollution; at the same time, the dressing absorbs wound exudate and adheres to the wound surface, causing damage to newborns during removal. organization, causing great pain to the patient

Method used

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  • Method for preparing sodium alginate-chitosan nano-grade medical dressing
  • Method for preparing sodium alginate-chitosan nano-grade medical dressing
  • Method for preparing sodium alginate-chitosan nano-grade medical dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] (1) preparation volume fraction is the aqueous solution of 20% ethanol; Preparation volume fraction is the aqueous solution of 1% acetic acid

[0028] (2) Disperse sodium alginate and polyoxyethylene in a 20% ethanol solution with a mass ratio of 3:7, the solution concentration is 4wt%, then fully stir the solution so that it is completely dissolved, and place the solution under ultrasonic waves for 1 After ~2 hours, all the bubbles are separated out to obtain a transparent sodium alginate electrospinning solution.

[0029] (3) The molecular weight is 5×10 4 The chitosan powder of g / mol was dispersed in 1% acetic acid solution, the solution concentration was 5wt%, and CaCl was added to the solution 2 As a cross-linking agent, the concentration is 5%, stirred until it is completely dissolved, and the solution is placed in an ultrasonic wave for 1 to 2 hours so that all the bubbles are precipitated to obtain a transparent chitosan receiving solution;

[0030] (4) Add th...

Embodiment 2

[0032] (1) preparation volume fraction is the aqueous solution of 20% ethanol; Preparation volume fraction is the aqueous solution of 2% acetic acid

[0033] (2) Disperse sodium alginate and polyoxyethylene in a 20% ethanol solution with a mass ratio of 3:7, the solution concentration is 4wt%, then fully stir the solution so that it is completely dissolved, and place the solution under ultrasonic waves for 1 After ~2 hours, all the bubbles are separated out to obtain a transparent sodium alginate electrospinning solution.

[0034] (3) Set the molecular weight to 1.0×10 5 The chitosan powder of g / mol was dispersed in 2% acetic acid solution, the solution concentration was 5wt%, and CaCl was added to the solution 2 As a cross-linking agent, the concentration is 5%, stirred until it is completely dissolved, and the solution is placed in an ultrasonic wave for 1 to 2 hours so that all the bubbles are precipitated to obtain a transparent chitosan receiving solution;

[0035] (4) ...

Embodiment 3

[0037] (1) preparation volume fraction is the aqueous solution of 30% ethanol; Preparation volume fraction is the aqueous solution of 2% acetic acid

[0038](2) Disperse sodium alginate and polyoxyethylene in a 30% ethanol solution with a mass ratio of 4:6, the solution concentration is 4wt%, then the solution is fully stirred so that it is completely dissolved, and the solution is placed in an ultrasonic wave for 1 After ~2 hours, all the bubbles are separated out to obtain a transparent sodium alginate electrospinning solution.

[0039] (3) Set the molecular weight to 1.0×10 5 The chitosan powder of g / mol is dispersed in 2% acetic acid solution, the solution concentration is 5wt%, adds MgCl to the solution 2 As a cross-linking agent, the concentration is 10%, stirred until it is completely dissolved, and the solution is placed in ultrasonic for 1 to 2 hours so that all the bubbles are precipitated to obtain a transparent chitosan receiving solution;

[0040] (4) Add the pr...

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Abstract

The invention relates to a method for preparing a sodium alginate-chitosan nano-grade medical dressing, and belongs to the field of natural biological polymer materials. The method comprises the following steps: dispersing sodium alginate and synthesized polymer in an ethanol solution; and preparing a chitosan solution containing a crosslinking agent to serve as a receiving liquid, wherein fibers are cross-linked by the crosslinking agent after the sodium alginate fibers are received in the chitosan solution, the electrolyte property of the chitosan is adsorbed to the surfaces of the sodium alginate fibers due to the electrostatic effect, and the prepared sodium alginate-chitosan composite nano-fibers have good air permeability and antibacterial and hemostasis effects, is advantageous to wound tissue growth and regeneration when being applied to a wound dressing, and can be used for accelerating wound healing. The method adopts a natural polymer matrix as a raw material, and the medical dressing has low cost, no toxicity and good biocompatibility.

Description

technical field [0001] The invention belongs to the technical field of natural biopolymer materials, and relates to a preparation method for preparing sodium alginate-chitosan nanoscale medical dressing technical background [0002] Chitosan (Chitosan, CS) is an abundant natural alkaline polysaccharide, second to cellulose in nature as the second largest biological resource, with good biocompatibility, biodegradability, human affinity and It has excellent properties such as antibacterial, hemostasis and promotion of wound healing. It can be absorbed by itself after use, does not cause allergies, can also accelerate wound healing, has a protective effect on large area burns, and can promote skin regeneration; the medical non-woven fabric produced by it can be Used on burn wounds and skin donor areas, it not only covers and protects the wounds, but also has low antigenicity. Therefore, chitosan biological dressing has been paid more and more attention in recent years, and is ...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/44D01F8/18D01F8/16D01F8/10D01F8/14D01F11/00
Inventor 孙开源
Owner 江苏开源康达医疗器械有限公司
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