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Method for producing shell-core structure medicament nano-fibre with coaxial electrostatic spinning technology

A technology of coaxial electrospinning and nanofibers, which is applied in the direction of spinning solution preparation, drug delivery, fiber treatment, etc., to meet the needs of tissue regeneration or patients, with low cost and mild reaction conditions

Inactive Publication Date: 2009-08-19
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no relevant report on the nanonization of drugs by coaxial electrospinning technology to achieve the control and release of drugs.

Method used

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  • Method for producing shell-core structure medicament nano-fibre with coaxial electrostatic spinning technology
  • Method for producing shell-core structure medicament nano-fibre with coaxial electrostatic spinning technology
  • Method for producing shell-core structure medicament nano-fibre with coaxial electrostatic spinning technology

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Weigh 0.3g of gelatin, 0.3g of bovine serum albumin and 0.01mg of VEGF with an electronic balance, and dissolve them in 10ml of ultrapure water at the same time under sterile conditions, stir and oscillate to dissolve completely to obtain a core layer solution;

[0028] Weigh 0.8g poly(lactic acid-caprolactone) P(LLA-CL)[50:50] and 0.01g heparin with an electronic balance, dissolve them together in 10ml of trifluoroethanol, stir and oscillate until completely dissolved, and obtain the shell solution;

[0029] For coaxial electrospinning, set the flow rate of the core layer solution to 0.2ml / h, the diameter of the spinneret to be 0.9mm, the flow rate of the shell solution to 1.0ml / h, and the diameter of the spinneret to be 1.2mm; 12 cm, and spinning; obtain "shell-core" structure nanofibers with a diameter of about 650 nm, wherein the core layer is about 100 nm.

Embodiment 2

[0031] Weigh 0.1g doxorubicin with an electronic balance, dissolve it in 10ml ultrapure water, stir and oscillate to dissolve completely to obtain a core layer solution;

[0032] Weigh 0.8g poly(lactic acid-caprolactone) P(LLA-CL)[50:50] and 0.05g paclitaxel respectively with an electronic balance, dissolve them together in 10ml of trifluoroethanol, stir and oscillate until completely dissolved, and obtain the shell solution;

[0033] For coaxial electrospinning, set the flow rate of the core layer solution to 0.4ml / h, the diameter of the spinneret to be 0.9mm, the flow rate of the shell solution to 1.0ml / h, and the diameter of the spinneret to be 1.2mm; 12 cm, and spinning; obtain a "shell-core" structure nanofiber with a diameter of about 500 nm, wherein the core layer is about 150 nm.

Embodiment 3

[0035] Weigh 0.3g tetracycline hydrochloride with an electronic balance, and dissolve it in 10ml ultrapure water under sterile conditions, stir and oscillate to dissolve completely to obtain a core layer solution;

[0036] Weigh 0.6g poly-L-lactic acid PLLA and 0.2g griseofulvin respectively with an electronic balance, dissolve them together in 10ml of chloroform, stir and oscillate until completely dissolved, and obtain a shell solution;

[0037] For coaxial electrospinning, set the flow rate of the core layer solution to 0.2ml / h, the diameter of the spinneret to be 0.9mm, the flow rate of the shell solution to 0.8ml / h, and the diameter of the spinneret to be 1.2mm; 12 cm, and spinning; obtain "shell-core" structure nanofibers with a diameter of about 800 nm, wherein the core layer is about 180 nm.

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Abstract

The invention relates to a method for preparing shell-core structured medicament nano fiber by coaxial electrostatic spinning technology, comprising: (1) dissolving high molecular polymer and medicament in mass proportion of 60-99.9:0.1-40 in organic solvent with high volatility, and stirring until complete dissolution to obtain shell solution; (2) dissolving one or more than one of natural polymer, medicament, and bioactive factor in the solvent, or dissolving the same in super pure water under aseptic condition to obtain core solution; and (3) carrying out coaxial electrostatic spinning, setting the spinning voltage at 15-25kv, the reception distance at 8-20cm, the spinning pushing speed at 0.1-1.5mL / h, and the spinning nozzle as 0.9mm, to obtain the shell-core structured medicament nano fiber. The preparation method is simple in operation, mild in reaction condition, low in cost and favorable for economic benefit; in preparing the shell-core structured medicament nano fiber, two or more than two medicaments can be simultaneously loaded and released, thus meeting requirements of tissue regeneration or patients.

Description

technical field [0001] The invention belongs to the field of preparing drug nanofibers with shell-core structure, in particular to a method for preparing drug nanofibers with shell-core structure by coaxial electrospinning technology. Background technique [0002] The electric method is to charge the polymer solution under a high-voltage electrostatic field, and to form filaments in the process of spraying to a low electric field, so that ultra-fine and uniform fibers with diameters from nanometers to micrometers can be obtained. Electrospinning first appeared in 1934. Formhals first introduced the method of using electrostatic repulsion to obtain polymer filaments in a patent. The principle is to use an external electric field force to make the polymer solution or melt overcome the surface tension in the capillary of the spinning nozzle. The tip forms a jet. When the electric field strength is high enough, under the joint action of electrostatic repulsion, Coulomb and surfa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D01D5/34D01D1/02A61K9/00
Inventor 莫秀梅苏艳李晓强周倩
Owner DONGHUA UNIV
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