93 results about "Molecular function" patented technology

Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The power of Nature and the flexibility of organic synthesis are combined in nucleic acid-templated synthesis. The present invention provides a variety of template architectures for performing nucleic acid-templated synthesis, methods for increasing the selectivity of nucleic acid-templated reactions, methods for performing stereoselective nucleic acid-templated reactions, methods of selecting for reaction products resulting from nucleic acid-templated synthesis, and methods of identifying new chemical reactions based on nucleic acid-templated synthesis.

Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The power of Nature and the flexibility of organic synthesis are combined in nucleic acid-templated synthesis. The present invention provides a variety of template architectures for performing nucleic acid-templated synthesis, methods for increasing the selectivity of nucleic acid-templated reactions, methods for performing stereoselective nucleic acid-templated reactions, methods of selecting for reaction products resulting from nucleic acid-templated synthesis, and methods of identifying new chemical reactions based on nucleic acid-templated synthesis.

Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The present invention provides methods, compositions, and systems for synthesizing, selecting, amplifying, and evolving non-natural molecules based on nucleic acid templates. The sequence of a nucleic acid template is used to direct the synthesis of non-natural molecules such as unnatural polymers and small molecules. Using this method combinatorial libraries of these molecules can be prepared and screened. Upon selection of a molecule, its encoding nucleic acid template may be amplified and / or evolved to yield the same molecule or related molecules for re-screening. The inventive methods and compositions of the present invention allow for the amplification and evolution of non-natural molecules in a manner analogous to the amplification of natural biopolymer such as polynucleotides and protein.

Modulating agents and methods for enhancing or inhibiting cadherin-mediated functions are provided. The modulating agents comprise at least an HAV binding motif, an analogue or peptidomimetic thereof, or an antibody or fragment thereof that specifically binds to such a motif. Modulating agents may additionally comprise one or more cell adhesion recognition sequences recognized by cadherins and / or other adhesion molecules. Such modulating agents may, but need not, be linked to a targeting agent, drug and / or support material.

A method for inhibiting or blocking molecular generating and / or inducing functions of molecules using an inhibitory or blocking agent of the formula:wherein R1-6 are as defined herein.

The present disclosure provides advantageous systems and methods for identifying molecular vulnerabilities in biological pathways and networks. The present disclosure generally involves conceptualizing a disease / disorder at the molecular level as a faulty physiological system, wherein one or more molecules in the complex intracellular signaling network are dysfunctional. This is accomplished by modeling a given physiological system as a digital logic circuit. More particularly, in exemplarily embodiments, binary logic equations are derived by analyzing the interactions between the input and output nodes of a target biological system. These equations are then used to produce a digital circuit representation for the system. Once a digital circuit representation is created, this circuit may advantageously be analyzed, using fault analysis techniques, in order to determine the vulnerability levels of the molecules of the targeted system.

An aquatic slurry of nano-TiO2 features its durable stability and dispersity without layering and depositing. Its preparing process features that the high-powder shearing-grinding apparatus is used to decoagulate the sintered TiO2 nanoparticles to become separated TiO2 nanoparticles, the proper molecular function groups and the surface covering agent are added for binding them with the acidic surface of TiO2, and the sterical hindering action and elestrostatic repelling action can make said TiO2 nanoparticles be dispersed in water-phase system stably.

The invention provides a multi-disease variable site analysis platform based on a function network. The multi-disease variable site analysis platform comprises a variable gene sequencing detection module, a function enrichment analysis module, a function network construction module, a function network mining module and a shared molecular network identification module, wherein the variable gene sequencing detection module is used for finishing the fundamental analysis of sequencing data; the function enrichment analysis module is used for utilizing a function enrichment analysis tool to analyze a variable gene function; the function network construction module is used for constructing the function network according to a function enrichment analysis result; the function network mining module is used for screening stable network modules from the function network; and the shared molecular network identification module is used for identifying molecular modules shared by different diseases according to the network module. The multi-disease variable site analysis platform analyses differences of different diseases on an aspect of genomic level, establishes an incidence relationship among the diseases from the perspective of molecular function, can systematically identity a shared modular function module among different diseases, effectively analyzes the nosogenesis of similar phenotype diseases, discloses differences between the diseases from the level of genome, increases the comprehensive understanding of the diseases and is favorable for clinic diagnosis and treatment.

The invention discloses a preparation method of a high molecule functionalized rare earth / mesoporous fluorescent nano-material. The preparation method comprises the following steps of: functionalizing organic high molecules with active functional groups by using a chemical modification and synthesis method at first; grafting to an inorganic and ordered mesoporous body SBA-15 or SBA-16 framework through a covalent bond; and then introducing rare earth europium ions to synthesize to obtain the highly ordered high molecule functionalized rare earth / mesoporous fluorescent nano-material with stable chemical and thermodynamic properties. The preparation method of the high molecule functionalized rare earth / mesoporous fluorescent nano-material is mild in experiment conditions that are easily controlled, an overall preparation system is easy to construct, is simple and convenient to operate, the obtained product has the advantages of stable quality, strong practicability and good repeatability.