The invention discloses a bio fertilizer that takes nitrogen, phosphorus and potassium as carriers and evericin mixture as desinsection component. The bio fertilizer comprises evericin mixture, ammonium sulphate, monoammonium phosphate, lemery, borax, zinc sulfate, green copperas, calcium powder, rootage agent, brown sugar, chicken manure, pepper powder, peanut cake or castor cake. The invention is suitable for various vegetables and melon and fruit crops; after application, the fruits of the crops grow right, the crops can ripe early and the flower is good-looking; the invention decreases the application of agricultural chemical, improves the output and melon and fruit saccharinity, saves cost about 20-30 percent; besides, the invention can effectively inhibit the increase of root nematode have special effect on white fly, the invention has the advantages of fertilizing effect as well as agricultural chemical effect, thus having very good practicality value.