The invention provides a high-yield culture method for planting cotton in a high-risk cotton region. The technology adopts double-wide-film mulching, the influence caused by low temperature, rain damage, wind damage and the like in spring on the seedling emerging is effectively resisted, and the seedling emerging is fast, regular and uniform; the multi-time intertillage and few-time chemical control technology in the seedling period is combined, the earth temperature is raised, the early emerging of strong seedlings is effectively promoted, and the seedling retaining rate and the strong seedling rate are improved; the water control is used as a main measure, the chemical control is used as an auxiliary measure, the water is saved, the pesticide is saved, and the premature senility is prevented; organic fertilizers (humic acid) and special fertilizers (special drip-irrigation fertilizers) are heavily applied, few chemical fertilizers are applied, the fertilizer effect is enhanced, and the soil and environment pollution is reduced; first watering is carried out later at proper time, the watering is stopped early, the water utilization rate is improved, and the early ripeness is promoted; top pruning is carried out early at proper time, the useless fruit branch number is reduced, the plant height is reduced, and the falling is prevented; maturity acceleration is carried out early at proper time, the harvesting can be carried out for many times in the early period, the loss rate is reduced by 5 to 10 percent, and the yield is improved.