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Applications of vagal stimulation

InactiveUS20050065553A1Prevent electrical remodelingEnhancing and sustaining efficacyHeart defibrillatorsHeart stimulatorsEncephalitisAnesthesia
A method is provided for treating a subject, including applying a current to a site of the subject selected from the list consisting of: a vagus nerve of the subject, an epicardial fat pad of the subject, a pulmonary vein of the subject, a carotid artery of the subject, a carotid sinus of the subject, a vena cava vein of the subject, and an internal jugular vein of the subject. The method also includes configuring the current so as to treat a condition of the subject selected from the list consisting of: an autoimmune disease, an autoimmune inflammatory disease, multiple sclerosis, encephalitis, myelitis, immune-mediated neuropathy, myositis, dermatomyositis, polymyositis, inclusion body myositis, inflammatory demyelinating polyradiculoneuropathy, Guillain Barre syndrome, myasthenia gravis, inflammation of the nervous system, inflammatory bowel disease, Crohn's disease, ulcerative colitis, SLE (systemic lupus erythematosus), rheumatoid arthritis, vasculitis, polyarteritis nodosa, Sjogren syndrome, mixed connective tissue disease, glomerulonephritis, thyroid autoimmune disease, sepsis, meningitis, a bacterial infection, a viral infection, a fungal infection, sarcoidosis, hepatitis, and portal vein hypertension.
Owner:MEDTRONIC INC

Implantable medical device for treating cardiac mechanical dysfunction by electrical stimulation

An implantable stimulator and monitor measures a group of heart failure parameters indicative of the state of heart failure employing EGM signals, measures of blood pressure including absolute pressure P, developed pressure (DP=systolic P-diastolic P), and/or dP/dt, and measures of heart chamber volume (V) over one or more cardiac cycles. These parameters include: (1) relaxation or contraction time constant tau (.tau.); (2) mechanical restitution (MR), i.e., the mechanical response of a heart chamber to premature stimuli applied to the heart chamber; (3) recirculation fraction (RF), i.e., the rate of decay of PESP effects over a series of heart cycles; and (4) end systolic elastance (E.sub.ES), i.e., the ratios of end systolic blood pressure P to volume V. These heart failure parameters are determined periodically regardless of patient posture and activity level. The physician can determine whether a particular therapy is appropriate, prescribe the therapy for a period of time while again accumulating the stored patient data for a later review and assessment to determine whether the applied therapy is beneficial or not, thereby enabling periodic changes in therapy, if appropriate. Drug therapies and electrical stimulation therapies, including PESP stimulation, and pacing therapies including single chamber, dual chamber and multi-chamber (bi-atrial and/or bi-ventricular) pacing can be delivered. In patient's prone to malignant tachyarrhythmias, the assessment of heart failure state can be taken into account in setting parameters of detection or classification of tachyarrhythmias and the therapies that are delivered.
Owner:MEDTRONIC INC

Portable patient monitor

Embodiments of the present disclosure includes a portable pulse oximeter, such as a handheld pulse oximeter, that provides a user with intuitive key navigation for device operation, which reduces an amount of visual concentration needed to handle and operate the oximeter. In various embodiments, the portable pulse oximeter includes one or more of user input keys disposed along curve, an alignment edge providing guidance by feel of a user's digits to the input keys, raised convex keys also providing navigation by feel, a protective boot disposed around various portions of the oximeter housing to protect against impacts, a table-top stand, combinations of the same, or the like.
Owner:MASIMO CORP

Utilization of Yb: and Nd: mode-locked oscillators in solid-state short pulse laser systems

An optimized Yb: doped fiber mode-locked oscillator and fiber amplifier system for seeding Nd: or Yb: doped regenerative amplifiers. The pulses are generated in the Yb: or Nd: doped fiber mode-locked oscillator, and may undergo spectral narrowing or broadening, wavelength converting, temporal pulse compression or stretching, pulse attenuation and / or lowering the repetition rate of the pulse train. The conditioned pulses are subsequently coupled into an Yb: or Nd: fiber amplifier. The amplified pulses are stretched before amplification in the regenerative amplifier that is based on an Nd: or Yb: doped solid-state laser material, and then recompressed for output.
Owner:IMRA AMERICA

Solid-state imaging apparatus and signal processing method for transforming image signals output from a honeycomb arrangement to high quality video signals

A solid-state imaging apparatus includes an image pick-up section in which photosensitive devices are arranged in, e.g., a honeycomb G square lattice, RB full-checker pattern due to shifted pixels. Regions void of the photosensitive devices are assumed to be virtual photosensitive devices. A signal processing section generates data for the virtual photosensitive devices by using the data of surrounding photosensitive devices while attaching importance to accurate color reproduction and horizontal and / or vertical resolution. As a result, the number of pixel data are increased in a square lattice arrangement. Therefore, high quality image signals are readily achievable with a smaller number of photosensitive devices than conventional with a conventional apparatus. Interpolation can be executed with the high quality signals to the limit of resolution with an adequate circuit scale. The honeycomb arrangement guarantees the required size of the individual pixel and thereby the sensitivity of the entire apparatus while increasing yield on a production line. False colors particular to a single photosensitive portion can be reduced by, e.g., uniform interpolation. Particularly, when a digital camera is constructed by using an imaging apparatus including optics operable with a silver halide sensitive type of film, false colors can be reduced without resorting to an optical low pass filter.
Owner:FUJIFILM CORP

Systems for heart treatment

InactiveUS20050187620A1Reduce stressSufficient exposure and visualizationHeart valvesCongestive heart failure chfTherapeutic treatment
Devices and methods for treating degenerative, congestive heart disease and related dysfunction are described. Passive and active cardiac support structures mitigate changes in ventricular structure (i.e., remodeling) and deterioration of global left ventricular performance related to tissue damage precipitating from ischemia, acute myocardial infarction (AMI) or other abnormalities. Cardiac efficiency is improved by providing reinforcement that restores or maintains an elliptical ventricular shape and mimics the position and positive inotropic effects of helical wound myofibrils to provide active contraction of the ventricle in synchrony with the metabolically required cardiac pace or output. In addition, the cardiac support structures compensate or provide therapeutic treatment for congestive heart failure and / or reverse the remodeling that produces an enlarged heart. The structures may be implanted in target heart regions using less invasive surgical techniques, such as those involving port access or small incisions into the thoracic cavity.
Owner:PAI SURESH +1

Method of optimizing cardiac resynchronization therapy using sensor signals of septal wall motion

The present invention relates to monitoring septal wall motion of the atrial and / or ventricular chambers of a heart for optimizing cardiac pacing intervals based on signals derived from said wall motion. At least one lead of medical device is equipped with a motion sensor adapted to couple to septal tissue. The device receives and may post-process (e.g., suitably filter, rectify and / or integrate) motion signals to determine acceleration, velocity or displacement. During pacing interval optimization the wall motion is measured for many pacing intervals and the pacing interval setting(s) that produce minimal wall motion are implemented for therapy delivery. In addition, the present invention provides methods for periodically determining whether to cease or resume delivery of a bi-ventricular pacing therapy to a patient that may have experienced beneficial reverse remodeling of the heart.
Owner:MEDTRONIC INC

Method and apparatus of a self-configured, model-based adaptive, predictive controller for multi-zone regulation systems

A control system simultaneously controls a multi-zone process with a self-adaptive model predictive controller (MPC), such as temperature control within a plastic injection molding system. The controller is initialized with basic system information. A pre-identification procedure determines a suggested system sampling rate, delays or “dead times” for each zone and initial system model matrix coefficients necessary for operation of the control predictions. The recursive least squares based system model update, control variable predictions and calculations of the control horizon values are preferably executed in real time by using matrix calculation basic functions implemented and optimized for being used in a S7 environment by a Siemens PLC. The number of predictions and the horizon of the control steps required to achieve the setpoint are significantly high to achieve smooth and robust control. Several matrix calculations, including an inverse matrix procedure performed at each sample pulse and for each individual zone determine the MPC gain matrices needed to bring the system with minimum control effort and variations to the final setpoint. Corrective signals, based on the predictive model and the minimization criteria explained above, are issued to adjust system heating/cooling outputs at the next sample time occurrence, so as to bring the system to the desired set point. The process is repeated continuously at each sample pulse.
Owner:SIEMENS IND INC
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