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459results about How to "Increase contractility" patented technology

Implantable medical device for treating cardiac mechanical dysfunction by electrical stimulation

An implantable stimulator and monitor measures a group of heart failure parameters indicative of the state of heart failure employing EGM signals, measures of blood pressure including absolute pressure P, developed pressure (DP=systolic P-diastolic P), and/or dP/dt, and measures of heart chamber volume (V) over one or more cardiac cycles. These parameters include: (1) relaxation or contraction time constant tau (.tau.); (2) mechanical restitution (MR), i.e., the mechanical response of a heart chamber to premature stimuli applied to the heart chamber; (3) recirculation fraction (RF), i.e., the rate of decay of PESP effects over a series of heart cycles; and (4) end systolic elastance (E.sub.ES), i.e., the ratios of end systolic blood pressure P to volume V. These heart failure parameters are determined periodically regardless of patient posture and activity level. The physician can determine whether a particular therapy is appropriate, prescribe the therapy for a period of time while again accumulating the stored patient data for a later review and assessment to determine whether the applied therapy is beneficial or not, thereby enabling periodic changes in therapy, if appropriate. Drug therapies and electrical stimulation therapies, including PESP stimulation, and pacing therapies including single chamber, dual chamber and multi-chamber (bi-atrial and/or bi-ventricular) pacing can be delivered. In patient's prone to malignant tachyarrhythmias, the assessment of heart failure state can be taken into account in setting parameters of detection or classification of tachyarrhythmias and the therapies that are delivered.
Owner:MEDTRONIC INC

Heart Valve Stent

InactiveUS20120283824A1Precise positioningSecure fixationSuture equipmentsStentsHeart chamberHeart valve stenosis
A heart valve stent having a section equipped to receive a heart valve implant and several proximally disposed anchoring elements, characterized by several anchoring threads, which with the one end thereof are fastened to the stent, and also with a brace fastening the anchoring threads with the other end thereof to the distal chamber wall to provide tension between the heart chamber wall and the proximally anchored anchoring elements.
Owner:LUTTER GEORG +1

Pacing with hemodynamic enhancement

Apparatus (170) for heart pacing with hemodynamic improvement, including one or more electrodes (36), which convey electrical signals to respective cardiac muscle segments. Signal generation circuitry (50) applies an extended pacing signal (60, 61), having an overall duration greater than three times a chronaxie time, to the one or more electrodes so as to pace the heart. The signal preferably includes a train of a plurality of biphasic pulses, and has an amplitude at least three times as great as a threshold for pacing the heart, but not sufficient for cardioversion.
Owner:IMPULSE DYNAMICS NV

Method of inotropic treatment of circulatory failure using hypothermia

A method for treating cardiac failure such as congestive heart failure by application of hypothermia. Hypothermia may be applied by endovascular cooling using a heat exchange catheter circulating heat exchange fluid between an external heat exchanger controlled using temperature feedback from a temperature probe on or in the patient to cool the heart to a sufficiently low temperature for a sufficient length of time to increase cardiac output and improve the vascular condition of the patient. The patient may be maintained in the hypothermic condition for a period of time and is then re-warmed slowly and controllably. The endovascular temperature management may be controlled automatically in response to a temperature probe on the patient, and shivering while the patient is cool may be combated using surface warming and anti-shivering drugs. The method is applicable to treat congestive heart failure and may be used repeatedly on the same patient to restore that patient to adequate heart function when the vascular condition of that patient has become unacceptable. The method may be used to maintain a patient until a heart transplant becomes available. The method may be used to stabilize a patient's condition to allow needed surgery or intervention. The method may be used in conjunction with other treatments including drugs, balloon pumps, pacing devices and ventricular assist devices.
Owner:ZOLL CIRCULATION

Aromatic-aliphatic polyester hot melt adhesives for roll-applied labels

Disclosed are hot-melt adhesives prepared from aromatic-aliphatic polyesters containing terephthalic acid in combination with adipic acid, glutaric acid, or a mixture thereof, as diacid components and a diol component containing 1,4-butanediol, 1,6-hexanediol, or a combination thereof. These adhesives set up rapidly within a well-defined temperature window. The hot-melt adhesives can be used in a variety of applications, but are especially suited as seaming adhesives for roll-applied labels. These adhesives have melting temperatures and crystallization properties that allow their application at temperatures cool enough to prevent curling and premature shrinkage of the shrink label during seaming, and yet produce strong label seams that can withstand the elevated temperatures of a shrink tunnel without sacrificing line speed. Also disclosed are labeled containers and a process for applying a roll-on, shrink label to a container using the hot-melt adhesives of the invention.
Owner:EASTMAN CHEM CO
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