66results about How to "Shorten the relaxation time" patented technology

An implantable stimulator and monitor measures a group of heart failure parameters indicative of the state of heart failure employing EGM signals, measures of blood pressure including absolute pressure P, developed pressure (DP=systolic P-diastolic P), and / or dP / dt, and measures of heart chamber volume (V) over one or more cardiac cycles. These parameters include: (1) relaxation or contraction time constant tau (.tau.); (2) mechanical restitution (MR), i.e., the mechanical response of a heart chamber to premature stimuli applied to the heart chamber; (3) recirculation fraction (RF), i.e., the rate of decay of PESP effects over a series of heart cycles; and (4) end systolic elastance (E.sub.ES), i.e., the ratios of end systolic blood pressure P to volume V. These heart failure parameters are determined periodically regardless of patient posture and activity level. The physician can determine whether a particular therapy is appropriate, prescribe the therapy for a period of time while again accumulating the stored patient data for a later review and assessment to determine whether the applied therapy is beneficial or not, thereby enabling periodic changes in therapy, if appropriate. Drug therapies and electrical stimulation therapies, including PESP stimulation, and pacing therapies including single chamber, dual chamber and multi-chamber (bi-atrial and / or bi-ventricular) pacing can be delivered. In patient's prone to malignant tachyarrhythmias, the assessment of heart failure state can be taken into account in setting parameters of detection or classification of tachyarrhythmias and the therapies that are delivered.

Disclosed is an implantable or insertable medical device comprising (a) a substrate and (b) a hydrogel polymer coating at a least a portion of the surface of the substrate, wherein the hydrogel polymer is adapted to render the medical device visible under magnetic resonance imaging (MRI) upon insertion or implantation of the medical device into a patient. Also disclosed is the use of such a hydrogel coated implantable or insertable medical device in a medical procedure, wherein during or after insertion or implantation of the medical device in a patient, the position of the medical device is viewed under MRI. The use of a hydrogel polymer for coating a medical device wherein the hydrogel polymer is adapted to render a medical device coated with the hydrogel polymer visible under MRI and a hydrogel polymer adapted to render a medical device coated therewith visible under MRI are also disclosed.

A dielectric element is formed of a dielectric material exhibiting a magnetic resonance relaxation time, with a relaxation agent incorporated in the dielectric material that reduces the relaxation time of the dielectric material. The dielectric element is adapted for placement on a subject while magnetic resonance data are acquired from the subject, and locally influences the B1 field distribution in the subject during the acquisition of magnetic resonance data.

Gadolinium+3 (Gd3+) containing (or incorporated) Prussian blue lattice contrast agents that can be used as an MRI contrast agent have unexpectedly improved r1 relaxivities of 1 or 2 magnitudes higher than the commercial Gd3+-chelates as well as exceedingly, non-toxic, low release of the Gd3+ ions into an aqueous environment at a pH of about 2 to about 7.5. The Prussian blue lattice containing Gd3+ ions therein can be used for clinical diagnosis intravenously to human beings for medical imaging. The particle sizes of the doped Prussian blue lattices are of a nanosize scale and are very stable against agglomeration.

Rheologically-modified functionalized polyolefins and tie-layer adhesive blends formulated therewith which exhibit improved adhesion in multi-layer barrier films are provided. Multi-layer barrier shrink films having improved adhesion are also disclosed.

The invention discloses a device for electronic device transfer. The device comprises an upper electrode layer, a lower electrode layer, a viscous layer and an electrical active layer, wherein the upper electrode layer and the lower electrode layer are arranged oppositely in a spaced mode, an electric field can be generated between the upper electrode layer and the lower electrode layer after electrification, the viscous layer is fixedly connected to the lower surface of the lower electrode layer, the electrical active layer is arranged between the upper electrode layer and the lower electrode layer and can be squeezed to deform longitudinally or horizontally under the action of the electric field generated between the two electrode layers after electrification, the deformation of the electrical active layer drives the electrode layers and the viscous layer to deform so that shearing force and / or concave-convex ejecting force can be generated, and then the electrode layers and the viscous layer are debonded to be placed on a receptor substrate. The invention further discloses a method for electronic device transfer by means of the device and the application of the device. The method and device can be used for active placing of electronic devices. The device is simple in structure, quick and reliable in use, easy to control and the like. The method and device can be used for transfer of ordinary ultrathin and flexible electronic devices in various specifications as well as transfer of large-area array micro-electronic devices / structures.

The invention relates to a rare earth-based nanoparticle magnetic resonance contrast agent and a preparation method thereof. The rare earth-based nanoparticle magnetic resonance contrast agent are rare earth-based inorganic nanoparticles having the surface coated with a hydrophilic ligand, firstly rare earth-based nanoparticles are obtained through a high-temperature oil phase reaction, and then the surface is coated with hydrophilic molecules to obtain the rare earth-based nanoparticle magnetic resonance contrast agent. Compared with a conventional clinical contrast agent, the magnetic resonance contrast agent has the relaxation rate greatly improved, is good in imaging effect, low in required injection dose, and relatively long in time staying in a body. In addition, a rigid structure of the inorganic nanoparticles can effectively reduce the free possibility of gadolinium ions. The rare earth-based nanoparticle magnetic resonance contrast agent has the advantages of simple preparation method, good repeatability and stable property, and easily realizes clinical commercial applications.

A mass spectrometer has an ion source (10) with a plurality of atmospheric pressure sample ioniser (20) mounted in a front face (15) thereof. Each sample ioniser (20) extends into a corresponding sample region (30) and the tip of each sample ioniser is mounted at right-angles to a corresponding one of a plurality of entrance cones (50) each having an entrance orifice (40) therein. Each entrance cone (50) in turn opens into an inlet channel having first and second parts (60, 70). The two parts of the inlet channel are separated by an electrical gate (65). The inlet channels corresponding to each entrance cone (50) all merge into a common exit channel (90) to a mass spectrometer. By appropriate operation of the gates (65) dividing the inlet channels, rapid switching between the samples that are analysed in the mass analyser can be achieved.

The invention relates to a zwitter ion modified dendritic macromolecular composite material, as well as preparation and application thereof. The composite material is dendritic macromolecular, and ismodified with zwitter ions and a targeting reagent RGD and chelated with gadolinium ions on the surface, and a gold nanoparticle is wrapped therein. The composite material is prepared by the followingsteps: preparing a G5-DOTA-(PEG-RGD) aqueous solution, adding an HAuCl4 solution and NaBH4 for reduction, adding dropwise a gadolinium nitrate solution, performing stirring for 12 h, adding dropwise1,3-PS, performing reaction for 24 h, and performing dialysis and lyophilization. The method is simple and has industrial and commercial potential, and the prepared nanoparticle is long in blood half-life in a mouse, and has a tumor CT / MRI dual-mode tomographic function at the animal level.

The invention discloses an ion migration tube. The ion migration tube comprises an ionization source device, an ion reaction device, an ion drifting device, an ion detection device and an outer tube,wherein the ion reaction device, the ion drifting device and the ion detection device are sequentially arranged in the outer tube; the ionization source device is connected with one end of the outer tube by threads, and is jacked against the ion reaction device; the outer casing is connected with the other end of the outer tube by threads, and is jacked against the ion detection device; the ion drifting device consists of insulation rings and electrode rings which are sequentially crossed and arranged; the two adjacent electrode rings are welded and connected together by a voltage division resistor; an ion migration zone is formed in an inner pore space of the insulation rings and electrode rings; the outer tube and the insulation rings of the ion migration tube are made of ceramic material with high heat conductivity. The ion migration tube has the beneficial effects that the sealing structure of the migration tube is improved; the heating rate is increased; the relaxation time is shortened when the positive and negative ion modes of the migration tube are switched; the technology is simplified; the uniformity and reliability of the migration tube are improved.

Multifunctional probes are synthesized in a single step using peptide scaffold-based multifunctional single-attachment-point reagents. To obtain multifunctional probes using the methods of the invention, a substrate (e.g., a nanoparticle, polymer, antibody, protein, low molecular weight compound, drug, etc.) is reacted with a multifunctional single-attachment-point (MSAP) reagent. The MSAP reagents can include three components: (i) a peptide scaffold, (ii) a single chemically reactive group on the peptide scaffold for reaction of the MSAP with a substrate having a complementary reactive group, and (iii) multiple functional groups on the peptide scaffold. The peptide scaffold can include any number of residues; however, for ease of synthesis and reproducibility in clinical trials, it is preferred to limit the residues in the peptide to 20 or less. The reagent can be prepared to yield a predetermined stoichiometric ratio of the functional groups on the scaffold such that the probe has a fixed stoichiometric ratio of the functional groups.

A dielectric element for positioning on an examination subject for locally influencing the B1 field distribution during magnetic resonance data acquisition contains a relaxation agent bound to mutually separated particles. The relaxation agent incorporates a paramagnetic substance. In a corresponding method for acquiring magnetic resonance data from an examination subject, such a dielectric element is positioned on the examination subject for locally influencing the B1 field distribution, by homogenizing the B1 field of a magnetic resonance apparatus.

The invention relates to a method for preparing a CT / MR dual-mode imaging contrast agent based on hyperbranched polyethyleneimine molecules. The method comprises the following steps: (1) adding an m-PEG-COOH solution activated by EDC / NHS into a hyperbranched polyethyleneimine solution, adding a DOTA-NHS solution, stirring, and reacting, thereby obtaining the functionalized polyethyleneimine PEI-mPEG-DOTA; (2) adding an HAuCl4 solution into the aqueous solution of PEI-mPEG-DOTA, reducing by using a NaBH4 solution, adding a Gd(NO3)3 solution, continuously stirring, and finally adding triethylamine and acetic anhydride, and reacting for 20-30 hours; and (3) dialyzing the solution obtained in the step (2), performing freeze drying, thereby obtaining the CT / MR dual-mode imaging contrast agent. According to the method disclosed by the invention, the low-price and readily available polyethyleneimine molecules are taken as carriers, so that the cost of the material is reduced, and the prepared CT / MR dual-mode imaging contrast agent has high biocompatibility and has good in-vivo and in-vitro CT and MR imaging effects.

A liposome containing a phosphatidylcholine and a phosphatidylserine in combination as membrane components at a phosphatidylcholine:phosphatidylserine molar ratio of 3:1 to 1:2, and said liposome containing superparamagnetic particles having a mean particle size not less than 1 nm and not more than 50 nm. A means for selectively accumulating an MRI contrast medium in a lesion of a vascular disease caused by abnormal proliferation of vascular smooth muscle cells such as arteriosclerosis and restenosis after PTCA is provided.

A dielectric element for positioning on an examination subject for locally influencing the B1 field distribution during magnetic resonance data acquisition contains a relaxation agent bound to mutually separated particles. The relaxation agent incorporates a paramagnetic substance. In a corresponding method for acquiring magnetic resonance data from an examination subject, such a dielectric element is positioned on the examination subject for locally influencing the B1 field distribution, by homogenizing the B1 field of a magnetic resonance apparatus.

In a magnetic recording device adopting a microwave assisted recording method, a microwave frequency on a positive polarity side and a microwave frequency on a negative polarity side are adjusted to be optimal.The magnetic recording device of the invention supplies to a magnetic head a write current of which a current waveform on the positive polarity side and a current waveform on the negative polarity side are asymmetric.

The invention provides a transition temperature method for detecting the aggregative state of asphalt with ultraviolet aging, which relates to a transition temperature method for detecting the aggregative state of the asphalt with the ultraviolet aging. The invention overcomes the defects that the existing transition method for detecting the aggregative state of the asphalt with the ultraviolet aging has complicated operation, high cost and disagreement with time-temperature equivalence principle. The transition performance method for the aggregative state of the asphalt with the ultraviolet aging is proceeded as the following steps: 1. frequency scanning is carried out, and the frequency scanning is carried out again after temperature rise or temperature drop; 2. the principal curve of the frequency scanning is obtained; 3. the time-temperature equivalent invalidation temperature of the aging asphalt is found out, and the temperature is the aggregative state transition temperature of the asphalt with the ultraviolet aging. The method has simple operation, low cost and conformity with time-temperature equivalence principle.

Gadolinium+3 (Gd3+) containing (or incorporated) Prussian blue lattice contrast agents that can be used as an MRI contrast agent have unexpectedly improved r1 relaxivities of 1 or 2 magnitudes higher than the commercial Gd3+-chelates as well as exceedingly, non-toxic, low release of the Gd3+ ions into an aqueous environment at a pH of about 2 to about 7.5. The Prussian blue lattice containing Gd3+ ions therein can be used for clinical diagnosis intravenously to human beings for medical imaging. The particle sizes of the doped Prussian blue lattices are of a nanosize scale and are very stable against agglomeration.

The invention relates to a preparation method of a high-biocompatibility dual-target modified Fe3O4 nano material, which comprises the following steps: dissolving ferric chloride and ferrous chloride ( the mole ratio of Fe<3+> to Fe<2+> is 2:1) in water by stirring, introducing an inert gas protective atmosphere, sequentially adding ammonia water and hyaluronic acid into the solution, reacting at room temperature for some time, carrying out cleaning purification on the obtained Fe3O4 nano material, dissolving the Fe3O4 nano material in a PBS (phosphate buffer solution), sequentially adding EDC (1-ethyl-3-(3-dimethylaminopropyl)carbodiimide) and NHS, stirring to react, and adding a targeted protein molecule to continue the reaction; and after the reaction finishes, carrying out cleaning purification on the obtained product again, dissolving the product in the PBS, and preserving at 4 DEG C. The method has the advantages of simple preparation process, environment-friendly raw materials and mild conditions. The obtained product has the advantages of favorable water solubility, favorable nuclear magnetism, high biocompatibility and high tumor targeted recognition capability, is convenient for large-scale production, and has great development potential and application value in the field of biological imaging.

The present invention discloses a nano composite. The nano composite is characterized by comprising photothermal conversion nanoparticles, a fusion agent, a paramagnetic component and an active targeting antibody; wherein the active targeting antibody contains carboxyl groups and the fusion agent contains amino groups; the carboxyl groups of the active targeting antibody is linked to the amino groups in the fusion agent. The nano composite has an active targeting property, integrates a magnetic effect and a photothermal effect in one, and particularly has better affinity for CD 133 receptor high-expression pancreatic cancer and related cancers. The present application also discloses a preparation method and an application of the nano composite. The method is mild in conditions, not high inrequirements on equipment, operation, environment, etc., economic and easily-obtained in raw materials, easy for implementation and good in stability and reproducibility. When the nano composite is used for magnetic resonance imaging and photothermal integration materials, the nano composite can effectively shorten T1 relaxation time, remarkably improves magnetic resonance T1 relaxation rate, andis better in T1 imaging, higher in contrast and also excellent in a near infrared photothermal effect.

Disclosed is an implantable or insertable medical device comprising (a) a substrate and (b) a hydrogel polymer coating at a least a portion of the surface of the substrate, wherein the hydrogel polymer is adapted to render the medical device visible under magnetic resonance imaging (MRI) upon insertion or implantation of the medical device into a patient. Also disclosed is the use of such a hydrogel coated implantable or insertable medical device in a medical procedure, wherein during or after insertion or implantation of the medical device in a patient, the position of the medical device is viewed under MRI. The use of a hydrogel polymer for coating a medical device wherein the hydrogel polymer is adapted to render a medical device coated with the hydrogel polymer visible under MRI and a hydrogel polymer adapted to render a medical device coated therewith visible under MRI are also disclosed.

The invention discloses a solid defect color center polarizability detection system and method. According to one embodiment of the present invention, a diamond material containing a high-concentrationNV (nitrogen-vacancy) center is adopted as a sensitive component; a sample is operated, the polarization of electron spin is realized; and the measurement of polarizability is realized through optical polarization pulses and an optimal pulse spin projection detection method. Compared with methods, such as methods for detecting spin-related fluorescence intensity, single-state infrared absorptionand current, the method provided by the invention can accurately measure the electron polarization and optical pumping rate of a solid defect color center, greatly improve a signal-to-noise ratio andgreatly shorten relaxation time, has a high application value for analyzing the performance of a quantum principle-based magnetic field measurement system, and will serve engineering practice such assensing measurement and control feedback.

The invention belongs to the technical field of drilling equipment, and particularly relates to a rapid drilling clamp for a round pipe, which comprises a bottom plate, a support block, a first roller, a first rotating shaft, a first motor, a positioning mechanism and a length fixing mechanism; a drilling mechanism moves downwards, a first spring is compressed, elastic force generated by the firstspring enables a positioning block to press the round pipe, a V-shaped groove automatically guides the round pipe, automatic positioning and clamping of the round pipe are achieved, and the positioning and clamping time is shortened; the drilling mechanism continues to move downwards for drilling; the drilling mechanism moves upwards to drive the upper end of the first spring to move upwards, when the tension of the first spring is larger than the gravity of the positioning block and a sliding block, the positioning block moves upwards, automatic loosening of the round pipe is achieved, and the loosening time is shortened; and after the round pipe is loosened, the first motor drives a second chain wheel to rotate, drives a first chain wheel to rotate and drives the first roller to rotate,so that the round pipe moves to the position determined by the length fixing mechanism, the drilling mechanism conducts drilling again, circulating drilling is achieved, and time is saved.

The invention discloses a novel rare earth nanometer bimodal developer, and a preparation method thereof and an application thereof. The novel rare earth nanometer bimodal developer is NaHoF4@CeO2 nanoparticles, and the preparation of the developer comprises the following steps: 1) preparation of NaHoF4 nanoparticles, 2) preparation of CeO2 nanoparticles, 3) adding nanometer CeO2 into NaHoF4 to obtain NaHoF4@CeO2 nanometer particles, the imaging agent is used in CT and MRI bimodal imaging. Physical and chemical characterization and toxicity test showed that the nanoparticles had good biological safety. In vitro experiment showed that the nanoparticles had good CT and MRI bimodal imaging effect, and had radiotherapy sensitization effect on pancreatic cancer cells.

The invention discloses a high-gain solar blind ultraviolet light detector based on a (GaY)2O3 amorphous film and a preparation method of the high-gain solar blind ultraviolet light detector. The detector sequentially comprises a c-plane sapphire, an active layer and a pair of parallel electrodes from bottom to top, wherein the active layer is the amorphous (GaY)2O3 film. According to the invention, Y3+ ions are used for partially replacing Ga3+ ions in Ga2O3, so that the band gap of Ga2O3 is increased, and the thin film is converted into amorphous from single crystal. The amorphous (GaY)2O3 film with a higher band gap can effectively reduce the dark current of the device, and enables the cut-off wavelength to be blue-shifted to be within 280nm. Meanwhile, the amorphous (GaY)2O3 film has higher defect concentration, and the defects not only can improve the gain, but also can be used as a recombination center to promote carrier recombination, so that compared with a pure Ga2O3 device, an amorphous (GaY)2O3 device has the advantages that the responsivity is obviously improved, the relaxation time is obviously shortened, and the detection capability on deep ultraviolet light is greatly improved.

The invention relates to medical hollow nanosphere with a double-shell porous structure and a preparation method thereof, the hollow nanosphere is of the double-shell structure, an inner shell is porous nano Zn (Fe, Ce) 2O4 ferrite, and an outer shell is formed by wrapping the surface of the inner shell with porous CeO2. The preparation method comprises the following steps: determining the molar ratio of each component according to Zn (Fe, Ce) 2O4; preparing a Zn (Fe, Ce) 2O4 ferrite precursor solution; adding the material into alcohol dispersed with phenolic resin microspheres and deionized water, regulating a pH value of a system to 9-10 for at least 3 hours, carrying out solid-liquid separation, washing the solid, carrying out vacuum drying, heating the material in air to 400-600 DEG C,and carrying out heat preservation to obtain the medical Zn (Fe, Ce) 2O4 / CeO2 porous structure hollow nanospheres. The prepared porous hollow nanosphere has the advantages of short relaxation time, good transverse relaxation efficiency, good fluorescence effect, excellent superparamagnetism, large specific surface area, high drug loading capacity, and realization of effective drug loading and release, and cavities and pores of the porous hollow nanosphere can accommodate loaded drugs.

A method of preparing a malleable and / or self-healing polymeric or composite material is provided. The method includes providing a polymeric or composite material comprising at least one alkene-containing polymer, combining the polymer with at least one homogeneous or heterogeneous transition metal olefin metathesis catalyst to form a polymeric or composite material, and performing an olefin metathesis reaction on the polymer so as to form reversible carbon-carbon double bonds in the polymer. Also provided is a method of healing a fractured surface of a polymeric material. The method includes bringing a fractured surface of a first polymeric material into contact with a second polymeric material, and performing an olefin metathesis reaction in the presence of a transition metal olefin metathesis catalyst such that the first polymeric material forms reversible carbon-carbon double bonds with the second polymeric material. Compositions comprising malleable and / or self-healing polymeric or composite material are also provided.

The invention relates to a medical instrument that can be inserted into a human or animal body, said medical instrument comprises an instrument body, and the instrument body comprises at least one poor electrically conducting rod-type body made of a matrix material and non-metallic filaments. The medical instrument is characterised in that the rod-shaped body is doped with X-ray marker particles, and the medical instrument comprises an MR-marker, or that the instrument body comprises an immobilised active MR marker in the surface area.

A dielectric element is formed of a dielectric material exhibiting a magnetic resonance relaxation time, with a relaxation agent incorporated in the dielectric material that reduces the relaxation time of the dielectric material. The dielectric element is adapted for placement on a subject while magnetic resonance data are acquired from the subject, and locally influences the B1 field distribution in the subject during the acquisition of magnetic resonance data.

The invention relates to polyacrylonitrile fibers and a wet spinning method thereof. According to the main technical scheme, the wet spinning method of the polyacrylonitrile fibers comprises the following steps: spinning: extruding a spinning solution through a spinning hole of a spinning assembly to obtain a spinning fine flow; solidifying and forming: enabling the spinning fine flow to enter a coagulation bath for coagulation forming to obtain nascent fibers; hot drafting treatment: carrying out multi-stage thermal drafting treatment on the nascent fibers; washing: washing the fibers subjected to hot drafting treatment; and drying and heat setting treatment: sequentially drying and heat-setting the washed fibers to obtain the polyacrylonitrile fibers. The polyacrylonitrile fibers are prepared by the wet spinning method of the polyacrylonitrile fibers. The polyacrylonitrile fibers are mainly used for ensuring the spinnability of the spinning solution in the spinning process, and the mechanical property of polyacrylonitrile fibers is improved.