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Nano composite, preparation method and application thereof

A technology of nanocomposites and complexes, applied in materials, biomaterials, and biological fields, can solve problems such as difficulty in accurate diagnosis, achieve high contrast, excellent photothermal effect, and improve T1 relaxation rate.

Inactive Publication Date: 2019-11-26
THE AFFILIATED HOSPITAL OF MEDICAL SCHOOL NINGBO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the bottleneck problems of traditional pancreatic cancer diagnosis and treatment include two aspects. One is that it is difficult to diagnose accurately in the early stage, and the other is its resistance to radiotherapy and chemotherapy.

Method used

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  • Nano composite, preparation method and application thereof
  • Nano composite, preparation method and application thereof
  • Nano composite, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0107] Example 1 Preparation of nanocomposite

[0108] 1 # Nanocomposite preparation

[0109] 1) According to the mass ratio of 1:5, weigh the black titanium dioxide and aminopolyethylene glycol carboxyl groups in sequence, and disperse them in an equal volume of deionized water to form a transparent solution. The concentration of black titanium dioxide is 2 grams per liter. Take 5 milliliters of each to mix, stir at 500 rpm for 24 hours at room temperature, and centrifuge to collect the precipitate.

[0110] 2) Dissolve the precipitate obtained in step 1) and gadoterate megluminate (DOTA-NHS) at a mass ratio of 50:1 in 10 ml of deionized water, mix well with ultrasound and stir for 48 hours, centrifuge to take the precipitate and vacuum dry .

[0111] 3) Take the dried precipitate obtained in step 2) and dissolve the CD133 antibody in 5 ml deionized water at a mass ratio of 400:1, mix well with ultrasound, stir for 24 hours, centrifuge to remove the supernatant to obtain a nanocomp...

Embodiment 2

[0153] Example 2 Structural Characterization of Nanocomposites

[0154] The structure of each nanocomposite prepared in the examples was characterized.

[0155] Take 1 # Nanocomposite samples are typical, figure 2 The 1 prepared in Example 1 is given # TEM image of the nanocomposite sample. It can be seen from the figure that the particle size of the nanocomposite is about 80nm. Figure 4 Is 1 # Physical image of the nanocomposite sample.

[0156] TEM photos and particle size of other nanocomposite samples and 1 # The samples are similar.

Embodiment 3

[0157] Example 3 Photothermal heating performance of nanocomposite

[0158] Take 1 # The nanocomposite sample is a typical sample, and the photothermal heating experiment is carried out.

[0159] Place 100 mg per liter of the compound described in Example 1 under a 808 nm laser, and observe its temperature with an infrared camera. Irradiate for 5 minutes each time, cool for 5 minutes, and repeat six times to observe the temperature rise and fall. The result is image 3 Shown. by image 3 It can be seen that the material can be stabilized at about 70°C after repeated heating for many times, and there is no obvious photothermal instability after five repeated heating, and it has the ability of repeated heating for many times, and it has good repeated heating for light and heat. effect. It can be seen that the nanocomposite still has good stability after repeated light and thermal heating.

[0160] The same photothermal heating experiment was performed on other nanocomposite samples...

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Abstract

The present invention discloses a nano composite. The nano composite is characterized by comprising photothermal conversion nanoparticles, a fusion agent, a paramagnetic component and an active targeting antibody; wherein the active targeting antibody contains carboxyl groups and the fusion agent contains amino groups; the carboxyl groups of the active targeting antibody is linked to the amino groups in the fusion agent. The nano composite has an active targeting property, integrates a magnetic effect and a photothermal effect in one, and particularly has better affinity for CD 133 receptor high-expression pancreatic cancer and related cancers. The present application also discloses a preparation method and an application of the nano composite. The method is mild in conditions, not high inrequirements on equipment, operation, environment, etc., economic and easily-obtained in raw materials, easy for implementation and good in stability and reproducibility. When the nano composite is used for magnetic resonance imaging and photothermal integration materials, the nano composite can effectively shorten T1 relaxation time, remarkably improves magnetic resonance T1 relaxation rate, andis better in T1 imaging, higher in contrast and also excellent in a near infrared photothermal effect.

Description

Technical field [0001] This application relates to a nanocomposite, its preparation method and application, and belongs to the fields of materials, biomaterials, and biotechnology. Background technique [0002] Pancreatic cancer has the characteristics of high malignancy, rapid metastasis, and poor prognosis, and is considered the king of cancer. According to the latest data from the American Cancer Society, about 80% of pancreatic cancer patients cannot survive for more than one year after diagnosis, and their five-year survival rate is less than 6%. At present, the bottleneck of traditional pancreatic cancer diagnosis and treatment includes two aspects. One is that it is difficult to diagnose accurately in the early stage, and the other is its resistance to radiotherapy and chemotherapy. Recently, a series of reports have confirmed that pancreatic cancer stem cells (PCSC), a subset of pancreatic cancer cells, not only show resistance to radiotherapy and chemotherapy, but are a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K49/16A61K49/12A61K49/10A61K49/18A61P35/00A61P1/18
CPCA61K41/0052A61K41/0057A61K49/101A61K49/126A61K49/16A61K49/1857A61K49/1875A61P1/18A61P35/00
Inventor 汪建华王思齐任文智蒋振奇吴爱国
Owner THE AFFILIATED HOSPITAL OF MEDICAL SCHOOL NINGBO UNIV
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