The invention discloses a T1 strengthened nanometer
magnetic contrast agent having the function of activating targeting properties of blood platelets and a preparation method of the T1 strengthened nanometer
magnetic contrast agent belonging to the field of
nuclear magnetic resonance contrast agents. The characteristics of "dissociation-self-
assembly" and surface modificability of an apoferritin nanometer cage under different pH environment are utilized, paramagnetic Gd-
DOTA is loaded into the apoferritin nanometer cage, ligand-KGDS
tetrapeptide specifically targeting and activating the bloodplatelets is coupled to the surface of Gd-loaded apoferritin, and therefore, nanometer particles which can actively target and activate the blood platelets and have
nuclear magnetic resonance T1 weighted imaging strengthened contrast effects can be obtained. The particle
diameter of the nanometer contrast agent is about 10nm, the nanometer contrast agent has favorable contrast effects, targeting properties for activating the blood platelets, and
biocompatibility; precise
visualization of
thrombosis is hopefully realized through targeting and activating the blood platelets, and more comprehensive molecule information is provided for early prevention, diagnosis and treatment of cardiovascular diseases.