33 results about "Magnetic contrast" patented technology

An EUV Lithography mask, a fabrication method, and use method thereof is provided. A preferred embodiment comprises a substrate, a Bragg reflector disposed upon the substrate, a buffer disposed upon the Bragg reflector, and an absorber layer disposed upon the buffer. The materials in the mask have selected magnetic properties. In a preferred embodiment, the buffer is a hard magnetic material, and the absorber is a soft magnetic material. Another preferred embodiment includes a mask manufacturing method further including a mask step. In a preferred embodiment, an electron mirror microscope is used to inspect the mask by imaging its topography with respect to its magnetic properties in an applied magnetic field.

A system and method for using electron beams with engineered phase dislocations as scanned probes in electron probe beam instruments such as scanning transmission electron microscopes. These types of electron beams have unique properties and can provide better information about a specimen than conventional electron beams. Phase dislocations may be created based on a pattern disposed on a nanoscale hologram, which may be placed in the electron optical column of the electron probe beam instrument. When an electron beam from the instrument is directed onto the hologram, phase dislocations may be imprinted onto the electron beam when electrons are diffracted from these holograms. For example, electron probe beams with spiral phase dislocations may occur. These spiral phase dislocations are formed using a hologram with a fork-patterned grating. Spiral phase dislocations may be used to provide magnetic contrast images of a specimen.

Method and system for background suppression in magneto-motive photoacoustic imaging of labeled target objects.

A document may include a non-magnetic substrate, a first colorant mixture printed as a first image upon the substrate, the first colorant mixture including a magnetic ink, and a second colorant mixture printed as a second image upon the substrate in substantially close spatial proximity to the printed first colorant mixture. The second colorant mixture may consist essentially of one or more non-magnetic inks and exhibit properties of both low visual contrast and high magnetic contrast against the first colorant mixture, such that the resultant printed substrate does not reveal the first image to the human eye, but will reveal the first image to a magnetic image reader.

The invention relates to a method for preparing ultrasonic magnetic resonance couple contrast agent. Wherein, it uses modified macromolecule polymer bubble case and the couple contrast agent that packs the magnetic contrast agent and biological active gas. The contrast agent is formed by bubble case of modified macromolecule polymer to pack magnetic resonance contrast agent and biological active gas, while the bubble case comprises macromolecule polymer, target antibody, surface activator; and in the couple contrast agent, as mass percentages, the macromolecule polymer is 10-30%, the carbowax is 1-10%, the surface activator is 0.01-5%, the target antibody is 5-10%, the magnetic resonance contrast agent is 0.4-1%, the biological active gas alorbatalotane is 1-5%m and the left is solvent. The invention can improve the stability and effect.

The invention discloses water-soluble NaYF4:Yb, Er@NaGdF4 core-shell nanocrystalline as well as a preparation method and applications of the water-soluble NaYF4:Yb, Er@NaGdF4 core-shell nanocrystalline in nuclear magnetic resonance. The preparation method of the water-soluble NaYF4:Yb, Er@NaGdF4 core-shell nanocrystalline is characterized by comprising the following steps: under the condition with excessive fluorinated ammonia and sodium hydroxide, rapidly injecting a compound formed by mixing ytterbium oleate, erbium oleate and yttrium oleate at a certain ratio at high temperature, thus preparing 10-sub-nanometer NaYF4: Yb, Er nanocrystalline, further rapidly injecting a certain amount of gadolinium oleate compound at high temperature, thus preparing oil-soluble NaYF4:Yb, Er@NaGdF4 core-shell nanocrystalline with a thin shell layer, and carrying out water-soluble surface modification on the oil-soluble NaYF4:Yb, Er@NaGdF4 core-shell nanocrystalline by adopting polyethylene glycol-polyacrylic acid (PEG-PAA), thus obtaining the target product. The preparation method of the water-soluble NaYF4:Yb, Er@NaGdF4 core-shell nanocrystalline is simple, the obtained product as a T1 nuclear-magnetic contrast agent has very high longitudinal Moore relaxation rate r1, wherein r1 is 15-25 mM<-1>S<-1>, and thus the product has a great clinical application value.

A magnetic contrast medium composite for nuclear magnetic resonance image diagnosis has magnetite and other magnetic matters as main raw materials. Magnetic material is powdered into 2-20 micron fine pwoder, and mixed with surfactant, stabilizer, excipient, chelating agent, corrective and other assistant; and the mixutre is further processed through surface shaping, dispersing and homogenization to produce a stable and homogeneous mixture suspension used as contrast medium for the nuclear magnetic resonance inspection of gastrointestinal tract and its peripheral tissue. The constrast medium is safe and absorption resistant, can be used to fill gastrointestinal tract continuously and has excellent usage effect. The present invention makes it possible to raise diagnosis level and expand the application range of nuclear magnetic resonance.

A system and method for using electron beams with engineered phase dislocations as scanned probes in electron probe beam instruments such as scanning transmission electron microscopes. These types of electron beams have unique properties and can provide better information about a specimen than conventional electron beams. Phase dislocations may be created based on a pattern disposed on a nanoscale hologram, which may be placed in the electron optical column of the electron probe beam instrument. When an electron beam from the instrument is directed onto the hologram, phase dislocations may be imprinted onto the electron beam when electrons are diffracted from these holograms. For example, electron probe beams with spiral phase dislocations may occur. These spiral phase dislocations are formed using a hologram with a fork-patterned grating. Spiral phase dislocations may be used to provide magnetic contrast images of a specimen.

Disclosed herein are photosensitizer particle contrast agents suitable for medical imaging and / or photodynamic therapy. The photosensitizer particle contrast agent has a shell and a core encased by the shell. The shell consists essentially of multiple photosensitizer conjugates. Each photosensitizer conjugate consists of a photosensitizer and at least one biodegradable polymer covalently bound to the photosensitizer. According to certain examples, the core has an echogenic contrast-enhancing material loaded therein. In alternative examples, the photosensitizer of at least one of the multiple photosensitizer conjugates has a magnetic contrast-enhancing agent, e.g., a paramagnetic ion, chelated thereto. Also disclosed herein are methods for medical imaging which use imaging compositions containing the photosensitizer particle contrast agents taught in the present disclosure.

The invention relates to a gold@gadolinium-based coordination polymer core-shell structure multifunctional nano compound material (Au@GdCP) prepared by compounding GdCP:Yb<3+> with up-conversion luminescence performance, Er<3+>(GdCP) nanoparticles and gold nanoparticles (AuNPs) by means of a one-pot method and application of the gold@gadolinium-based coordination polymer core-shell structure multifunctional nano compound material (Au@GdCP) in T1 weighted magnetic resonance imaging (T1-MRI). According to the gold@gadolinium-based coordination polymer core-shell structure multifunctional nano compound material (Au@GdCP) and the application thereof, due to a strong plasma resonance effect (LRET), the gold nanoparticles can improve the magnetic field strength on the periphery of the GdCP and thus play a part in improving the contrast relaxation rate and MRI effect; an adopted hydrothermal synthesis method has the advantages of simple synthesis route, easy adjustment and control, greenness,efficiency and the like; the Au@GdCP can be applied to magnetic contrast imaging due to good biocompatibility, and thus a new pathway is provided for obtaining an efficient magnetic resonance imagingmaterial.

The invention relates to a temperature changing detection system and method for a nuclear magnetic contrast agent. The system comprises a sample pipe fixing device, a circulation water tank and an automatic control system, wherein the sample pipe fixing device is a cylindrical member which is internally provided with multiple slots, each slot is internally fixed with a sample pipe containing the contrast agent, a temperature control sensor is attached to an outer wall of each sample pipe, an opening end of each slot is embedded with a circulation water pipeline, the circulation water tank is externally communicated with the multiple circulation water pipelines and is internally provided with a circulation pump, the automatic control system has a control circuit which is electrically connected with the circulation water tank and the temperature control sensors of the multiple sample pipes, the control circuit is used for monitoring deviation of temperature values of the sample pipes acquired by the temperature control sensors and preset temperature and adjusting temperature of circulation water according to deviation till the temperature values acquired by the temperature control sensors reach the preset temperature. The system is advantaged in that through automatically adjusting the temperature of the contrast agent in the sample pipes, and a relaxation rate measurement error caused by internal and external temperature difference can be eliminated.

Disclosed is a lymph targeting nuclear magnetic contrast agent using a brown algae polysaccharide as a carrier, and a preparation method and a use thereof. A macromolecular contrast agent with good water solubility was prepared by using the brown algae polysaccharide as the carrier, using mannose or mannose derivatives as a mannose receptor (MBP) recognition group, and using a paramagnetic metal ion chelate as a nuclear magnetic resonance imaging group. The binding capacity of lymphoid tissue was improved. The mannose or mannose derivative group introduced into the synthesized contrast agent molecule achieves the goal of binding to the enriched mannose receptors in the lymphoid tissues. At the same time, after the contrast agent is injected subcutaneously, both lymph vessels and lymph nodes were clearly visualized under MRI scanning The intensification rate and enhancement time of the lymph node signal at one side of the animal body injected with the contrast agent was significantly enhanced, so as to achieve a clear mapping and precise positioning of the lymph nodes and the lymph vessels. It is of great significance for the detection and diagnosis of lymph system diseases.

Method and system for background suppression in magneto-motive photoacoustic imaging of labeled target objects.

The invention discloses a targeted nuclear magnetism contrast agent and a preparation method thereof. The contrast agent is ferroferric oxide (Fe3O4) composite magnetic nanoparticles coated with chitosan (CS) modified by folic acid (FA) grafted with amine-PEG-carboxyl (NH2-PEG-COOH). The method comprises the steps: under an environment of a DMSO solvent, activated FA and NH2-PEG-COOH are subjected to dicyclohexylcarbodiimide (DCC) crosslinking, dialysis and freeze-drying, and an FA-PEG-COOH compound is obtained; then the FA-PEG-COOH compound is added into a solution containing Fe3O4 coated with CS, crosslinking and dialysis are carrying out, and the functionalized Fe3O4 composite magnetic nanoparticles coated with FA-PEG-CS are obtained, wherein crosslinking agents are 1-(3-dimethyl aminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) and N-hydroxy succinimide (NHS). The multifunctional composite magnetic nanoparticle preparation is spherical-like in shape, has the particle size distributed between 100 and 250 nm in a water environment, has the electric potential of +20 mV, and has good stability, strong targeting property, and excellent image enhancement effect.

The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and iron stabilized micelles comprising the same, as magnetic contrast agents. Compositions herein are useful for diagnostic and drug-delivery applications.

The invention discloses a method for producing a sub 10-nanometer calcium fluoride core-shell nanocrystal, and application thereof in nuclear magnetic resonance. The method comprises the following steps: rapidly injecting a complex of ytterbium oleate, erbium oleate and calcium oleate at high temperature under excess amount of ammonium fluoride and sodium hydroxide, to obtain a sub 10-nanometer CaF2: Yb, Er nanocrystal; then continuously rapidly injecting the complex of ytterbium oleate, erbium oleate and calcium oleate to obtain a larger-size sub10-nanometer CaF2: Yb, Er nanocrystal; rapidlyinjecting a complex of gadolinium oleate and calcium oleate at high temperature to prepare a sub 10-nanometer CaF2: Yb / Er @ CaF2: Gd core-shell nanocrystal; and performing water-soluble surface modification to obtain the water-soluble target product. The preparation method of the core-shell nanocrystal, provided by the invention, is simple, and the obtained product as a T1 nuclear magnetic contrast agent has the very high vertical molar relaxation rate r1, and has the relatively great clinical application value.

The invention relates to a gadolinium ion based zeolite metal organic frame material, and a preparation method and an application of the material. The material has a formula of [Gd48(NO3)48(bpdc)48]*Gx, wherein bpdc is 2,2'-6,6'-pyridine diacid salt; G is a solvent molecule; the organic solvent is a mixture of methanol and trichloromethane at a volume ratio of 1:1 or a mixture of alcohol and dichloromethane at a volume ratio of 1:1; x is solvent molecule quantity with a scope of greater than 1; and the prepared gadolinium ion based zeolite metal organic frame material is used for a thermal imaging technology as a nuclear magnetic contrast agent. The material has the advantages that the material prepared by the method shows a high highfield relaxation rate and temperature selectivity; the highfield relaxation rate is higher than that of a clinical contrast agent; the preparation method is simple; industrial amplification is easy; the treatment is simple; and the material is applicable to the common clinical nuclear magnetic imaging and hyperthermia physiotherapy imaging, good in compatibility and wide in application.

A document may include a non-magnetic substrate, a first colorant mixture printed as a first image upon the substrate, the first colorant mixture including a magnetic ink, and a second colorant mixture printed as a second image upon the substrate in substantially close spatial proximity to the printed first colorant mixture. The second colorant mixture may consist essentially of one or more non-magnetic inks and exhibit properties of both low visual contrast and high magnetic contrast against the first colorant mixture, such that the resultant printed substrate does not reveal the first image to the human eye, but will reveal the first image to a magnetic image reader.

A triphenylamine terpyridine manganese complex having double functions including two-photon development and magnetic resonance development and a synthetic method thereof are disclosed. The structure formula of the complex is shown in the description. The complex has a two-photon development function and a magnetic resonance development function, and can be adopted as a contrast medium for double modes. Compared with a commercial nuclear magnetic contrast medium that is Gd-DTPA, the complex can be ingested by cells well so that magnetic resonance signals are enhanced.

The invention discloses a method for preparing a nano-silica / ferric oxide magnetic contrast particle reinforced biological magnesium-based composite material, and relates to a method for preparing a magnesium-based composite material. The invention aims to solve the technical problems of poor targeting and positioning ability and low forming ability of existing biomedical magnesium-based composite materials. The present invention: 1. Preparation of nano-magnetic imaging particle combination; 2. Ultrasonic coupling and stirring self-regulating treatment, graded and variable temperature impregnation and hot pressing forming. In the present invention, high-temperature mechanical ball milling is beneficial to improve the interfacial activity of nano-silica hollow microspheres and ferroferric oxide magnetic particles, and the ultrasonic coupling and stirring self-regulating treatment can reduce magnesium liquid inclusions, improve tissue uniformity, and enhance targeting and positioning capabilities. Graded variable temperature hot pressing can further improve the infiltration capacity, reduce casting defects and refine grains, and under the action of ultrasonic coupling stirring self-regulation treatment and graded variable temperature impregnation hot pressing, the strength and toughness of magnesium matrix composites can be significantly improved .

A method and system for performing simultaneous topographic and elemental chemical and magnetic contrast analysis in a scanning, tunneling microscope. The method and system also includes nanofabricated coaxial multilayer tips with a nanoscale conducting apex and a programmable in-situ nanomanipulator to fabricate these tips and also to rotate tips controllably.

Disclosed is a lymph targeting nuclear magnetic contrast agent using a brown algae polysaccharide as a carrier, and a preparation method and a use thereof. A macromolecular contrast agent with good water solubility was prepared by using the brown algae polysaccharide as the carrier, using mannose or mannose derivatives as a mannose receptor (MBP) recognition group, and using a paramagnetic metal ion chelate as a nuclear magnetic resonance imaging group. The binding capacity of lymphoid tissue was improved. The mannose or mannose derivative group introduced into the synthesized contrast agent molecule achieves the goal of binding to the enriched mannose receptors in the lymphoid tissues. At the same time, after the contrast agent is injected subcutaneously, both lymph vessels and lymph nodes were clearly visualized under MRI scanning. The intensification rate and enhancement time of the lymph node signal at one side of the animal body injected with the contrast agent was significantly enhanced, so as to achieve a clear mapping and precise positioning of the lymph nodes and the lymph vessels. It is of great significance for the detection and diagnosis of lymph system diseases.

The invention provides an arteriovenous blood vessel circulation abnormal cell capture device. The device is used for capturing abnormal cells separated from solid tumors and entering arteriovenous vessels, and comprises a magnetic contrast agent and a capturing assembly, wherein the magnetic contrast agent contains immunomagnetic particles with magnetic nanoparticles as inner cores and specific antibodies on the surface layers, and binding particles used for being specifically bound to the abnormal cells to obtain binding particles bound with the abnormal cells; and the capturing assembly isused for capturing the binding particles and comprises a capturing guide wire, a capturing catheter and a telescopic control part. The capture guide wire is provided with a head section, a magnetic guide wire section and a non-magnetic guide wire section which are arranged in sequence; the capture catheter is arranged outside the magnetic guide wire section and the non-magnetic guide wire sectionin a sleeving manner; and the telescopic control part has a fixed sleeve and a telescopic rod, wherein one end of the fixed sleeve is fixed to the other end of the non-magnetic guide wire section, thetelescopic rod is embedded into the other end of the fixed sleeve, the end, facing the fixed sleeve, of the telescopic rod is fixedly arranged at the other end of the non-magnetic guide wire section,and the telescopic rod is used for being screwed into or out of the fixed sleeve to enable the magnetic guide wire section to extend out of the capture catheter.

The invention provides a nuclear magnetic contrast agent with oligomer specificity as well as a preparation method and application of the nuclear magnetic contrast agent. The nuclear magnetic contrastagent with oligomer specificity comprises ferroferric oxide ferromagnetic nanoparticles and a single-chain antibody; the ferroferric oxide ferromagnetic nanoparticles are coated in polyethylene glycol dicarboxylate; and the single-chain antibody is connected to the outer surface of polyethylene glycol dicarboxylate. The nuclear magnetic contrast agent with oligomer specificity, prepared by usingthe preparation method provided by the invention, is capable of penetrating through a blood brain barrier, identifying and bonding with various brain oligomers, good in specificity, high in stability,good in biocompatibility and relaxation property and capable of reducing the toxicity of the oligomers and has a good application prospect and a relatively high application value in a preparation fortreating or diagnosing amyloid protein diseases.

The invention discloses a permanent magnet synchronous motor. The technical scheme is that the permanent magnet synchronous motor includes a rotor iron core; irregularly shaped cage strips are arranged on the outer side of the rotor iron core along the axial direction of a rotor. The bottom corner of a radial part of each irregularly shaped cage strip is clamped in a slot of a corresponding shapein a silicon steel sheet on the rotor iron core. Two ends of each irregularly shaped cage strip are connected with end rings fixedly and permanent magnets are embedded between the irregularly shaped cage strips. The magnetic properties of the permanent magnets between two adjacent poles are opposite. The magnetic properties of the permanent magnets between adjacent H-shaped irregularly shaped cagestrips in one polar zone are identical. The invention has beneficial effects that irreversible mechanical deformation due to extrusion of a magnetic path can be avoided effectively and structure reliability is realized.

A method and system for performing simultaneous topographic and elemental chemical and magnetic contrast analysis in a scanning, tunneling microscope. The method and system also includes nanofabricated coaxial multilayer tips with a nanoscale conducting apex and a programmable in-situ nanomanipulator to fabricate these tips and also to rotate tips controllably.