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Arteriovenous blood vessel circulation abnormal cell capture device

A technology of abnormal cells and capture devices, which is applied in the field of medical equipment and can solve problems such as complicated operation methods, expensive instruments, and difficult promotion

Pending Publication Date: 2020-10-30
蒋霆辉 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the instruments required for these technologies are not only expensive, but also complicated to operate, making it difficult to popularize

Method used

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  • Arteriovenous blood vessel circulation abnormal cell capture device
  • Arteriovenous blood vessel circulation abnormal cell capture device
  • Arteriovenous blood vessel circulation abnormal cell capture device

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preparation example Construction

[0033] Among them, a certain concentration of Fe 3 o 4 The nanoparticle solution preparation method comprises the following steps:

[0034] Step 1: Prepare a 250mL three-neck bottle, nitrogen bag, electric stirrer, heat-collecting constant temperature magnetic stirrer, glass tube, rubber tube, ground plug, etc., check the air tightness after installation, and weigh FeCl with an analytical balance 3 .6H 2 O4.68g, weigh FeSO 4 .7H 2 O2.6g, the FeCl 3 .6H 2 O was added to the three-necked flask, and 40 mL of pure water was added to the three-necked flask with a measuring cylinder, and nitrogen gas was introduced into the three-necked flask, and the electric stirrer was started (speed: 150r / min), and the mixture in the three-necked flask was stirred to dissolve the solid to obtain the first Five solutions;

[0035] Step 2, the weighed FeSO 4 .7H 2 0 and 40mL of pure water were added into a three-necked flask, and the stirring was continued for 15min to obtain the sixth so...

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Abstract

The invention provides an arteriovenous blood vessel circulation abnormal cell capture device. The device is used for capturing abnormal cells separated from solid tumors and entering arteriovenous vessels, and comprises a magnetic contrast agent and a capturing assembly, wherein the magnetic contrast agent contains immunomagnetic particles with magnetic nanoparticles as inner cores and specific antibodies on the surface layers, and binding particles used for being specifically bound to the abnormal cells to obtain binding particles bound with the abnormal cells; and the capturing assembly isused for capturing the binding particles and comprises a capturing guide wire, a capturing catheter and a telescopic control part. The capture guide wire is provided with a head section, a magnetic guide wire section and a non-magnetic guide wire section which are arranged in sequence; the capture catheter is arranged outside the magnetic guide wire section and the non-magnetic guide wire sectionin a sleeving manner; and the telescopic control part has a fixed sleeve and a telescopic rod, wherein one end of the fixed sleeve is fixed to the other end of the non-magnetic guide wire section, thetelescopic rod is embedded into the other end of the fixed sleeve, the end, facing the fixed sleeve, of the telescopic rod is fixedly arranged at the other end of the non-magnetic guide wire section,and the telescopic rod is used for being screwed into or out of the fixed sleeve to enable the magnetic guide wire section to extend out of the capture catheter.

Description

technical field [0001] The invention belongs to the field of medical equipment, and in particular relates to a device for capturing abnormal cells in arteriovenous blood circulation. Background technique [0002] The metastasis of cancer is largely due to the fact that the cancer cells shed from the primary tumor flow to other organs through the blood, reach the metastases, and form new tumors. At present, a large number of cancer-related researches are based on such abnormal cells with metastatic function. The detection of abnormal cells after capture has been used in a new liquid diagnostic method. Through the detection of such abnormal cells, it is possible to obtain More metastases-related information can track the direction of cancer metastasis and predict the prognosis of treatment. [0003] Currently, fluorescent immunoassays and magnetic immunoassays are mainly used to capture abnormal cells with metastatic function in cancer patients. However, the instruments requ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/00C12M1/42
CPCC12M47/04
Inventor 蒋霆辉宋萍梁晓飞陆珺孙剑玥殷佩浩茅爱武孙贤俊
Owner 蒋霆辉
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