The invention discloses a large cross-section and multiple cross-section tunnel lining construction method. Combined type lining trolleys are chosen to carry through the trolley assembly lining to the cross-section, and adding a gantry mounting on the basis of a normal trolley single gantry mounting can form an assembled and detachable lining trolley. Steel molding plates, road wheels, main gantry mountings, etc. are listed in unchanged components in the process of the assembly trolleys with different cross-sections, and lateral adjusting driving screws, upper platform chord members, upper platform upright posts, lining steel arches, etc. are listed in adjustable components. In the process of the construction from one cross-section to another cross-section, the unchanged components do not change, and only the changeable components are carried through the refitting and assembly. The construction method has the characteristics of fast construction progress, low cost, easy control of site construction management, etc., can save a great deal of manpower, physical resources and financial resources and obtain good technical economic effect, and has the remarkable economic, social and environmental benefits; the invention is especially adapted to the large cross-section and multiple cross-section type lining construction of tunnels and underground constructions.