329 results about "Abnormal cell" patented technology

Disclosed are a 2,7-substituted thieno[3,2-d]pyrimidine compound having a protein kinase inhibition activity, a pharmaceutically acceptable salt, and a pharmaceutical composition for prevention and treatment of diseases caused by abnormal cell growth comprising the compound as an effective ingredient.

Since the novel 2,7-substituted thieno[3,2-d]pyrimidine compound exhibits superior inhibition activity against various protein kinases involved in growth factor signal transduction, it is useful as an agent for preventing or treating diseases caused by abnormal cell growth.

The invention discloses a segmentation method of pathological section unconventional cells based on a multi-scale hybrid segmentation model. The method comprises steps that positive and negative samples are respectively scaled to low-resolution, medium-resolution and high-resolution images, the full convolutional network algorithm is utilized for training to acquire a convergent low-resolution segmentation model, a medium-resolution segmentation model and a high-resolution model; a multi-scale hybrid segmentation model is acquired through fusion by a model integration method; after the effective discriminating area of a new pathological section is processed through utilizing the data enhancement method during testing, the processed effective discriminating area is inputted to the multi-scale hybrid segmentation model, the probability of each pixel in the effective segmentation area is outputted, pixels with probability values greater than the threshold t are taken as abnormal cell pixels and are recorded as 1, remaining pixels are taken as normal cell pixels and are recorded as 0, binary images predicted by the multi-scale hybrid segmentation model are acquired, and post-processingon the binary images is carried out to acquire the final segmentation result. The method is advantaged in that high precision is realized, and a Dice value is above 0.869.