The invention relates to a pH / reduction dual-sensitive multifunctional nano-
micelle for
tumor chemotherapy and photothermal
combined therapy and application of the pH / reduction dual-sensitive multifunctional nano-
micelle. The pH / reduction dual-sensitive multifunctional nano-
micelle is characterized in that a PCL-
acetal-PEG
polymer with pH sensitive characteristic, a PCL-ss-PEG-ss-PCL
polymer withreduction sensitive characteristic and a
phospholipid DSPE-PEG-NH2 with an
active group are used as raw materials and are blended to prepare a pH / reduction intelligent
responsive polymer nano-micelleas a carrier; a chemotherapeutic
drug and a
photosensitizer coat a hydrophobic core of the micelle; a casing is made of hydrophilic PEG and has the characteristic of long circulation and space stability; a
folic acid targeting group is modified on the surface of the micelle by a
covalent bond; the
drug loading capacity is 4 to 10 percent, and the
mass ratio of the chemotherapeutic
drug to the
photosensitizer is 0.5 to 2; the particle size is smaller than 200 nm. The pH / reduction dual-sensitive multifunctional nano-micelle disclosed by the invention has the advantages of good
dispersity, smallparticle size, better
photothermal conversion effect and high drug loading capacity and encapsulation efficiency; the effect of improving tumor suppression by
tumor targeted administration,
fluorescence imaging of a
tumor site, pH / reduction triggered
drug release and
chemotherapy and photothermal
combined therapy can be realized; the pH / reduction dual-sensitive multifunctional nano-micelle has a broad clinical application prospect in combined
targeting therapy of tumors.