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Molybdenum oxide based nano photothermal conversion material and preparation method thereof

A nano-material and nano-light technology is applied in the field of molybdenum oxide nano-photothermal conversion material and its preparation, which can solve the problems of easy deformation of precious metals, high cost of precious metals, and unstable photothermal performance, etc., and achieves strong near-infrared light. absorption effect

Inactive Publication Date: 2013-12-18
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the noble metal is easily deformed after laser irradiation, the photothermal performance is unstable
And the high cost of precious metals also limits their wide application

Method used

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  • Molybdenum oxide based nano photothermal conversion material and preparation method thereof
  • Molybdenum oxide based nano photothermal conversion material and preparation method thereof
  • Molybdenum oxide based nano photothermal conversion material and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0037] 60mL of H 2 o 2 Add dropwise to 4.78g molybdenum powder, and keep stirring to form a yellow solution, and then dilute the solution to 100mL to obtain a molybdenum precursor solution. Add 10g of PEG to 20mL of molybdenum precursor solution, stir to form a transparent yellow solution, transfer it to a polytetrafluoroethylene reactor, seal it, and then raise the temperature to 150°C in a blast oven for 12 hours. After the reaction, the product was collected by centrifugation and washed with deionized water. The prepared MoO 3-x Nanobelts such as figure 1 a,b,c shown. MoO 3-x Nanoribbons can be well dispersed in water, appear blue and have gradually enhanced near-infrared light absorption properties, such as figure 1 d. The energy spectrum under the transmission electron microscope proves that it contains molybdenum and oxygen elements, such as figure 2 . The prepared MoO 3-x XRD patterns of nanobelts and standard MoO 3 (JCPDS, no35-0609) corresponding to the ...

Embodiment 2

[0039] 60mL of H 2 o 2 Add dropwise to 4.78g molybdenum powder, and keep stirring to form a yellow solution, and then dilute the solution to 100mL to obtain a molybdenum precursor solution. Add 10g of PEG to 20mL of molybdenum precursor solution, stir to form a transparent yellow solution, transfer it to a polytetrafluoroethylene reactor, seal it, and then raise the temperature to 90°C in a blast oven for 12h. After the reaction, the product was collected by centrifugation and washed with deionized water. The prepared MoO 3-x Nanospheres such as Figure 6a,b,c shown. MoO 3-x Nanospheres can be well dispersed in water, appear blue and have strong near-infrared light absorption, with a peak at 750nm, such as Figure 6 d. At a power of 2W / cm 2 Excited by an 808nm laser, the MoO 3-x Nanospheres can absorb 808nm laser light and generate heat effectively, raising the ambient temperature by 35°C within 5 minutes, such as Figure 7 .If MoO 3-x Nanospheres were incubated wit...

Embodiment 3

[0041] 60 mL of H 2 o 2 Add dropwise to 4.78g molybdenum powder, and keep stirring to form a yellow solution, and then dilute the solution to 100mL to obtain a molybdenum precursor solution. Dissolve 5g of PVP in 10mL of water, then add it to 10mL of molybdenum precursor solution, stir to form a transparent yellow solution, transfer it to a polytetrafluoroethylene reactor, seal it, and then heat it up to 120°C in a blast oven for 12h. After the reaction, the product was collected by centrifugation and washed with deionized water. The prepared MoO 3-x Nanorods such as Figure 8 shown. MoO 3-x Nanorods have strong near-infrared light absorption, and their absorption peak is at 700nm, such as Figure 9 shown. If MoO 3-x Nanospheres were incubated with cancer cells, and after 10 minutes of 808nm laser irradiation, the local temperature increased rapidly, and MoO 3-x Nanospheres can effectively kill cancer cells.

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Abstract

The invention relates to a molybdenum oxide based nano photothermal conversion material and a preparation method thereof. The photothermal material is a MoO<3-x> nano material, wherein x is not less than 0 and not more than 1. The preparation method of the photothermal material comprises the following steps: adding H2O2 to elementary molybdenum, stirring the materials and then diluting the materials, thus obtaining a molybdenum precursor solution; adding a surfactant to the molybdenum precursor solution, stirring the mixture uniformly and then carrying out hydrothermal reaction and centrifugation, thus obtaining the molybdenum oxide based nano photothermal conversion material. The efficient molybdenum oxide based nano photothermal material is prepared by the simple, environment-friendly and cheap method provided by the invention and shows a huge application value in cancer treatment.

Description

technical field [0001] The invention belongs to the field of photothermal conversion materials and their preparation and application, and in particular relates to a molybdenum oxide nanometer photothermal conversion material and a preparation method thereof. Background technique [0002] As a minimally invasive treatment, photothermal therapy uses photothermal reagents to convert the light energy of a laser into heat energy to kill cancer cells. The near-infrared laser used in photothermal therapy has a wavelength of 700-1100nm and has a tissue penetration depth of several centimeters. Photothermal therapy has attracted great attention as a supplement to traditional therapeutic methods. Noble metal nanomaterials are the most widely explored near-infrared photothermal materials, including Au nanorods, Au nanocages, Au nanoshells, and Pd nanosheets. The near-infrared absorption of noble metals originates from the surface plasmon resonance effect, which depends on the structu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01G39/02A61K41/00A61K33/24A61P35/00B82Y30/00B82Y40/00
Inventor 胡俊青宋国胜周颖李文尧安磊
Owner DONGHUA UNIV
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