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Medical hollow nanosphere with double-shell porous structure and preparation method thereof

A technology of hollow nanometer and porous structure, applied in the field of biomedical magnetic materials, can solve unseen problems, achieve uniform size, facilitate imaging and medical imaging diagnosis, and have good transverse relaxation efficiency

Active Publication Date: 2020-01-10
CENT SOUTH UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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  • Medical hollow nanosphere with double-shell porous structure and preparation method thereof
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  • Medical hollow nanosphere with double-shell porous structure and preparation method thereof

Examples

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Embodiment 1

[0049] (1) Preparation of phenolic resin microspheres. Measure 200ml of deionized water, 10ml of absolute ethanol and 1ml of ammonia water into a dry 500ml three-neck flask and mix, add 1g of resorcinol, slowly add 2ml of formaldehyde solution, and stir in an oil bath at 30°C for 10h. After the reaction, the mixed solution was transferred to a high-pressure reactor, and placed in a vacuum drying oven at 80° C. for hydrothermal reaction for 22 hours for aging. Then the solid and liquid were separated, and the solid was vacuum-dried at 80° C. for 24 hours to obtain phenolic resin (PF) microspheres with a size of about 200 nm.

[0050] (2) Preparation of rare earth ion Ce 3+ Doped Zn(Fe,Ce) 2 o 4 Ferrite precursor solution. According to Zn(Fe,Ce) 2 o 4 Molar ratio, respectively weigh appropriate amount of nitrate, including Zn(NO 3 ) 2 , Fe(NO 3 ) 3 and Ce(NO 3 ) 3 , Put the weighed several nitrates into the beaker, and add an appropriate amount of deionized water at ...

Embodiment 2

[0059] (1) Preparation of phenolic resin microspheres. Measure 300ml of deionized water, 40ml of absolute ethanol and 10ml of ammonia water into a dry 500ml three-necked flask and mix, add 10g of resorcinol, then slowly add 6ml of formaldehyde solution to the mixed solution, and stir in an oil bath at 40°C for 12h. After the reaction, the mixed solution was transferred to a high-pressure reactor, and placed in a vacuum drying oven at 100° C. for hydrothermal reaction for 26 hours for aging. Then the solid and liquid were separated, and the solid was vacuum-dried at 80° C. for 24 hours to obtain phenolic resin (PF) microspheres with a size of about 800 nm.

[0060] (2) Preparation of rare earth ion Ce 3+ Doped Zn(Fe,Ce) 2 o 4 Ferrite precursor solution. According to Zn(Fe,Ce) 2 o 4 Molar ratio, respectively weigh appropriate amount of nitrate, including Zn(NO 3 ) 2 , Fe(NO 3 ) 3 and Ce(NO 3 ) 3 , Put the weighed several nitrates into the beaker, and add an appropria...

Embodiment 3

[0069](1) Preparation of phenolic resin microspheres. Measure 270ml of deionized water, 25ml of absolute ethanol and 5ml of ammonia water into a dry 500mL three-neck flask and mix, add 6g of resorcinol, slowly add 3ml of formaldehyde solution, and stir in an oil bath at 30°C for 12h. After the reaction, the mixed solution was transferred to a high-pressure reactor, and placed in a vacuum oven at 100° C. for hydrothermal reaction for 24 hours for aging. Separation of solid and liquid, take the solid and vacuum dry at 70°C to obtain phenolic resin (PF) microspheres with a size of about 500nm.

[0070] (2) Preparation of rare earth ion Ce 3+ Doped Zn(Fe,Ce) 2 o 4 Ferrite precursor solution. According to Zn(Fe,Ce) 2 o 4 Molar ratio, respectively weigh appropriate amount of nitrate, including Zn(NO 3 ) 2 , Fe(NO 3 ) 3 and Ce(NO 3 ) 3 , Put the weighed several nitrates into the beaker, and add an appropriate amount of deionized water at the same time, fully dissolve in a...

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Abstract

The invention relates to medical hollow nanosphere with a double-shell porous structure and a preparation method thereof, the hollow nanosphere is of the double-shell structure, an inner shell is porous nano Zn (Fe, Ce) 2O4 ferrite, and an outer shell is formed by wrapping the surface of the inner shell with porous CeO2. The preparation method comprises the following steps: determining the molar ratio of each component according to Zn (Fe, Ce) 2O4; preparing a Zn (Fe, Ce) 2O4 ferrite precursor solution; adding the material into alcohol dispersed with phenolic resin microspheres and deionized water, regulating a pH value of a system to 9-10 for at least 3 hours, carrying out solid-liquid separation, washing the solid, carrying out vacuum drying, heating the material in air to 400-600 DEG C,and carrying out heat preservation to obtain the medical Zn (Fe, Ce) 2O4 / CeO2 porous structure hollow nanospheres. The prepared porous hollow nanosphere has the advantages of short relaxation time, good transverse relaxation efficiency, good fluorescence effect, excellent superparamagnetism, large specific surface area, high drug loading capacity, and realization of effective drug loading and release, and cavities and pores of the porous hollow nanosphere can accommodate loaded drugs.

Description

technical field [0001] The invention discloses a hollow nanosphere with a double-shell porous structure for medical use and a preparation method; in particular, it relates to a medical superparamagnetic Zn(Fe,Ce) 2 o 4 / CeO 2 A hollow nanosphere with a double-shell porous structure and a preparation method thereof. The invention belongs to the technical field of biomedical magnetic materials. Background technique [0002] At present, the incidence of cancer is increasing year by year. The key clinical problems that need to be solved in the treatment of cancer include: accurate in vivo fluorescence imaging of tumors, magnetic resonance imaging (MRI) visualized precise resection, and precise targeted drug delivery chemotherapy for laryngeal squamous cell carcinoma cells. . The current organic fluorescent dyes used in fluorescence imaging have disadvantages such as short fluorescence lifetime of dye molecules, lack of tumor tissue specificity, and poor photochemical stabili...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K47/02A61K31/704A61P35/00A61K49/00A61K49/18
CPCA61K9/5115A61K31/704A61K49/0002A61K49/0093A61K49/1818A61P35/00
Inventor 李丽娅邓茹心高智葛毅成
Owner CENT SOUTH UNIV
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