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Implantable medical device for treating cardiac mechanical dysfunction by electrical stimulation

An implantable stimulator and monitor measures a group of heart failure parameters indicative of the state of heart failure employing EGM signals, measures of blood pressure including absolute pressure P, developed pressure (DP=systolic P-diastolic P), and/or dP/dt, and measures of heart chamber volume (V) over one or more cardiac cycles. These parameters include: (1) relaxation or contraction time constant tau (.tau.); (2) mechanical restitution (MR), i.e., the mechanical response of a heart chamber to premature stimuli applied to the heart chamber; (3) recirculation fraction (RF), i.e., the rate of decay of PESP effects over a series of heart cycles; and (4) end systolic elastance (E.sub.ES), i.e., the ratios of end systolic blood pressure P to volume V. These heart failure parameters are determined periodically regardless of patient posture and activity level. The physician can determine whether a particular therapy is appropriate, prescribe the therapy for a period of time while again accumulating the stored patient data for a later review and assessment to determine whether the applied therapy is beneficial or not, thereby enabling periodic changes in therapy, if appropriate. Drug therapies and electrical stimulation therapies, including PESP stimulation, and pacing therapies including single chamber, dual chamber and multi-chamber (bi-atrial and/or bi-ventricular) pacing can be delivered. In patient's prone to malignant tachyarrhythmias, the assessment of heart failure state can be taken into account in setting parameters of detection or classification of tachyarrhythmias and the therapies that are delivered.
Owner:MEDTRONIC INC

Silicon device on Si:C-OI and SGOI and method of manufacture

A semiconductor structure and method of manufacturing is provided. The method of manufacturing includes forming shallow trench isolation (STI) in a substrate and providing a first material and a second material on the substrate. The first material and the second material are mixed into the substrate by a thermal anneal process to form a first island and second island at an nFET region and a pFET region, respectively. A layer of different material is formed on the first island and the second island. The STI relaxes and facilitates the relaxation of the first island and the second island. The first material may be deposited or grown Ge material and the second material may deposited or grown Si:C or C. A strained Si layer is formed on at least one of the first island and the second island.
Owner:IBM CORP

Dispersible alcohol/cleaning wipes via topical or wet-end application of acrylamide or vinylamide/amine polymers

ActiveUS20060003649A1Desired level of strength of the fibrous substrateEnhance a fibrous substrateCosmetic preparationsToilet preparationsFiberPolymer
The present invention is directed to a wet wipe product. The wet wipe product comprises a fibrous substrate and a triggerable binder formulation. The triggerable binder formulation is capable of binding the fibers in the fibrous substrate. The triggerable binder formulation may include acrylamide polymers, vinylamide / amine polymers, and mixtures. The triggerable binder formulation is insoluble in a wetting composition comprising an insolubilizing agent but is dispersible in disposal water.
Owner:MGL TECHNICAL ASSOC LLC
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