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5013results about How to "Reduced response" patented technology

Cryotreatment device and method

Devices and methods for cooling vessel walls to inhibit restenosis in conjunction with medical procedures such as coronary artery angioplasty. Stenosed vessel walls can be cooled prior to angioplasty, after angioplasty, or both. The invention is believed to inhibit restenosis through cooling to a temperature near freezing, preferably without causing substantial vessel wall cell death. One catheter device includes a distal tube region having coolant delivery holes radially and longitudinally distributed along the distal region. In some devices, holes spray coolant directly onto the vessel walls, with the coolant absorbed into the blood stream. In other embodiments, a balloon or envelope is interposed between the coolant and the vessel walls and the coolant returned out of the catheter through a coolant return lumen. Some direct spray devices include an occlusion device to restrict blood flow past the region being cooled. Pressure, temperature, and ultrasonic probes are included in some cooling catheters. Pressure control valves are included in some devices to regulate balloon interior pressure within acceptable limits. In applications using liquid carbon dioxide as coolant, the balloon interior pressure can be maintained above the triple point of carbon dioxide to inhibit dry ice formation. Some cooling catheters are coiled perfusion catheters supporting longer cooling periods by allowing perfusing blood flow simultaneously with vessel wall cooling. One coiled catheter is biased to assume a coiled shape when unconstrained and can be introduced into the body in a relatively straight shape, having a stiffening wire inserted through the coil strands.
Owner:BOSTON SCI SCIMED INC

Sulfonated block copolymers, method for making same, and various uses for such block copolymers

The present invention is a, solid block copolymer comprising at least two polymer end blocks A and at least one polymer interior block B wherein each A block is a polymer block resistant to sulfonation and each B block is a polymer block susceptible to sulfonation, and wherein said A and B blocks do not contain any significant levels of olefinic unsaturation. Preferably, each A block comprising one or more segments selected from polymerized (i) para-substituted styrene monomers, (ii) ethylene, (iii) alpha olefins of 3 to 18 carbon atoms; (iv) hydrogenated 1,3-cyclodiene monomers, (v) hydrogenated monomers of conjugated dienes having a vinyl content less than 35 mol percent prior to hydrogenation, (vi) acrylic esters, (vii) methacrylic esters, and (viii) mixtures thereof; and each B block comprising segments of one or more polymerized vinyl aromatic monomers selected from (i) unsubstituted styrene monomers, (ii) ortho-substituted styrene monomers, (iii) meta-substituted styrene monomers, (iv) alpha-methylstyrene, (v) 1,1-diphenylethylene, (vi) 1,2-diphenylethylene and (vii) mixtures thereof. Also claimed are processes for making such block copolymers, and the various end uses and applications for such block copolymers.
Owner:KRATON POLYMERS US LLC

Emergency location transceivers (ELT)

Emergency Location Transceivers (ELT) and communication transceivers (transmitters and receivers) for reception and demodulation of location finder signals, Global Positioning System (GPS) satellite signals and non GPS satellite location finder and other location finder signals. The received location finder signals are demodulated to location finder baseband signals. Baseband signal processors for processing single or a plurality of input signals for providing Orthogonal Frequency Division Multiplex (OFDM) baseband signals, filtered signals, cross-correlated shaped in-phase and quadrature-phase baseband signals and spread spectrum signals. Signal modulators for modulating the processed signals and for providing the modulated signals to the signal transmitter for transmission of the modulated signals. Emergency receiver systems for reception, demodulation and processing of the modulated transmitted signals. Certain emergency receiver embodiments, such as receivers of calls made to emergency call number 911 contain two or more receive antennas for reception and processing of the transmitted modulated signal. In certain embodiments emergency receiver systems have two or more receive antennas operated in a diversity mode, for reception and processing of the transmitted modulated signal.
Owner:FEHER KAMILO

Air based emergency monitor, multimode communication, control and position finder system

Air based emergency monitor, multimode communication, control and position finder system with a receiver having multiple inputs for reception and demodulation of position finder signals to position finder baseband signals. One or more cameras or microphones or data signal generation devices, storage devices, and processors for recording or storing and processing of signals obtained from one or more cameras or microphones or data signal generation devices. A processor for processing input signals and for providing cross-correlated shaped in-phase and quadrature-phase baseband signals. Transceivers for multimode GSM, spread spectrum, CDMA, OFDM, TDMA and other signals. A receiver and demodulator for reception of modulated position finder radio frequency (RF) signals transmitted by a Global Positioning System (GPS) transmitter and a receiver and demodulator for reception of modulated position finder radio frequency (RF) signals transmitted by other than a GPS transmitter for providing the demodulated and receiver processed signal to an emergency unit. An air based position finding, signal monitor, control and emergency multimode communication system for use in one or more units located in or on airplanes, or helicopters, or unmanned vehicles (UV) or balloons or rockets, or missiles, or space shuttles or birds or other air based items with a multimode bit rate agile (BRA) and modulation demodulation (modem) format selectable (MFS) signal modulator.
Owner:FEHER KAMILO

Exhaust aftertreatment system using urea water

An exhaust aftertreatment system comprises an injector for injecting urea water into an exhaust duct, and a denitration catalyst disposed downstream of the injector with respect to a flow of exhaust gas. The exhaust aftertreatment system reduces nitrogen oxides in the exhaust gas by the denitration catalyst while using ammonia produced from the urea water injected from the injector. The urea water is injected along a direction of the flow of the exhaust gas within the exhaust duct, and a porous plate is disposed in multiple stages in a space of the exhaust duct such that droplets of the injected urea water impinge against the porous plate before reaching a wall surface of the exhaust duct. A surface of the porous plate subjected to the impingement of the droplets is arranged to face downstream with respect to the flow of the exhaust gas. Deposition of the urea water is prevented by causing film boiling when the droplets impinge against the porous plate, and the urea water reflected by the porous plate is uniformly dispersed into the exhaust gas. Thus, the urea water is uniformly dispersed into the exhaust gas without increasing a pressure loss of the exhaust gas. The urea water is prevented from depositing on the wall surface and producing a precipitate in the form of a solid.
Owner:HITACHI HIGH-TECH CORP +2

Cryotreatment device and method

Devices and methods for cooling vessel walls to inhibit restenosis in conjunction with medical procedures such as coronary artery angioplasty. Stenosed vessel walls can be cooled prior to angioplasty, after angioplasty, or both. The invention is believed to inhibit restenosis through cooling to a temperature near freezing, preferably without causing substantial vessel wall cell death. One catheter device includes a distal tube region having coolant delivery holes radially and longitudinally distributed along the distal region. In some devices, holes spray coolant directly onto the vessel walls, with the coolant absorbed into the blood stream. In other embodiments, a balloon or envelope is interposed between the coolant and the vessel walls and the coolant returned out of the catheter through a coolant return lumen. Some direct spray devices include an occlusion device to restrict blood now past the region being cooled. Pressure, temperature, and ultrasonic probes are included in some cooling catheters. Pressure control valves are included in some devices to regulate balloon interior pressure within acceptable limits. In applications using liquid carbon dioxide as coolant, the balloon interior pressure can be maintained above the triple point of carbon dioxide to inhibit dry ice formation. Some cooling catheters are coiled perfusion catheters supporting longer cooling periods by allowing perfusing blood flow simultaneously with vessel wall cooling. One coiled catheter is biased to assume a coiled shape when unconstrained and can be introduced into the body in a relatively straight shape, having a stiffeninig wire inserted through the coil strands.
Owner:BOSTON SCI SCIMED INC

Immunoconjugates and humanized antibodies specific for B-cell lymphoma and leukemia cells

A chimeric LL2 monoclonal antibody is described in which the complementarity determining regions (CDRs) of the light and heavy chains of the murine LL2 anti-B-lymphoma, anti-leukemia cell monoclona lantibody has been recombinantly joined to the human kappa and IgG1 constant region domains, respectively, which retains the immunospecificity and B-cell lymphoma and leukemia cell internalization capacity of the parental murine LL2 monoclonal antibody, and which has the potential of exhibiting reduced human anti-mouse antibody production activity. A humanized LL2 monoclonal antibody is described in which the CDRs of the light and heavy chains have been recombinantly joined to a framework sequence of human light and heavy chains variable regions, respectively, and subsequently linked to human kappa and IgG1 constant region domains, respectively, which retains the immunospecificity and B-lymphoma and leukemia cell internalization capacities of the parental murine and chimeric LL2 monoclonal antibodies, and which has the potential for exhibiting reduced human anti-mouse antibody production activity. Vectors for producing recombinant chimeric and humanized chimeric monoclonal antibodies are provided. Isolated DNAs encoding the amino acid sequences of the LL2 variable light and heavy chain and CDR framework regions are described. Conjugates of chimeric and humanized chimeric LL2 antibodies with cytotoxic agents or labels find use in therapy and diagnosis of B-cell lymphomas and leukemias.
Owner:IMMUNOMEDICS INC
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