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464results about How to "Improve the effect of treatment" patented technology

Recombinant adeno-associated virus-NADH dehydrogenase sigmasubunit 4 gene total length for treating Leber hereditary optic neuropathy and medicament

The invention discloses a recombinant adeno-associated virus-NADH dehydrogenase sigmasubunit 4 gene total length for treating Leber hereditary optic neuropathy and a medicament. The total length of the gene is shown in a nucleotide sequence SEQ ID NO:1, wherein the nucleotide sequence, consisting of a CAG starter sequence, a coded sequence of ND4 of a mitochondrial localization sequence with Cox10 and UTR with the length of 625bp, has the total length of 3824bp. The medicament is injected into an eye vitreous chamber and is used for treating Leber hereditary optic neuropathy; because the medicament can be injected into the vitreous chamber, the activity can be kept in the vitreous chamber, and the medicament can be effectively subjected to transfection to optic nerve cells; signal peptide at the front end of the protein N directionally guides the protein to enter mitochondria, and the mature protein ND4 enters the mitochondria to play a function; therefore, the Leber hereditary optic neuropathy can be effectively treated by using the medicine.
Owner:WUHAN NEUROPHTH BIOTECHNOLOGY LTD CO

Structure and method for treating severe disengagement, cracking and other defects of tunnel lining

The invention discloses a structure and method for treating severe disengagement, cracking and other defects of a tunnel lining. According to the method, original defective secondary lining concrete is chiseled away, and an inverted trapezoidal groove with the inside being wide and the outside being narrow is formed; steel bars are embedded in the middle of the groove in the annular direction and the longitudinal direction, and meanwhile, the steel bars and the original concrete are anchored integrally; self-propelled hollow grouting anchor rods are drilled in the groove area and surrounding the groove at the same time, and the outer side and the inner side, close to the secondary lining, of each anchor rod are wrapped with two water-swelling rubber water stop strips; and after a formwork is erected on the outer surface of the secondary lining, micro-expansion concrete is poured into the groove and is tightly connected with an original primary support and the secondary lining, so that a new lining structure is formed, the outer surface area of the micro-expansion concrete extends around till reaching the design thickness of the secondary lining and then extends again by 80-100 cm within which steel belts are hung for anchorage. The structure and method can effectively treat the defects of severe cracking and disengagement of the lining, the structure stability is good, the mechanical property is high, the problem that the defects occur again in the later period is avoided, the treatment method is high in operability, safe and reliable, and great economic benefits are achieved.
Owner:CHANGAN UNIV

Method and system for treating fly ash in manner combining mechanochemistry and washing, with characteristics of high efficiency, low cost and zero harm

ActiveCN105013798AEfficient solidification of heavy metalsEfficiently achieve degradabilitySolid waste disposalElectronic waste recyclingEnvironmental resistanceResource utilization
The invention relates to the field of harmless fly ash treating, and provides a method and system for treating fly ash in a manner combining mechanochemistry and washing, with characteristics of high efficiency, low cost and zero harm. The system comprises a feed bin, a horizontal roller type ball mill, a stirring kettle and a plate-and-frame filter press, wherein the bottom of the feed bin is connected to a feed opening of the horizontal roller type ball mill; stainless steel milling balls are placed in a closed barrel body of the horizontal roller type ball mill; two ends of a discharge pipeline are connected to the bottom of the horizontal roller type ball mill and the upper part of the stirring kettle respectively; the upper part of the stirring kettle is connected with a water inlet pipeline, and the bottom of the stirring kettle is connected to the plate-and-frame filter press. According to the method and the system which are disclosed by the invention, the heavy metal solidification, the dioxin degradation and the chlorine removal of the fly ash can be realized at the same time in high efficiency, the treated fly ash is thoroughly harmless and has conditions of resource utilization, and the heavy metal solidification rate of the treated fly ash is more than 70%; an additive is not additionally added, so that the treating cost is low; the technological process is simple, the reaction conditions are mild, the treating process is environment friendly, and harmful by-products are not generated; the equipment investing cost and the operating cost are low, the treating effects are significant, and the technological process is simple to realize.
Owner:ZHEJIANG UNIV

Surgical training and evaluation method on basis of virtual reality

The invention discloses a surgical training and evaluation method on the basis of virtual reality. The surgical training and evaluation method is implemented by a database module and execution modules. The database module is divided into a training and evaluation question bank, a surgical stage scene model library, a medical equipment and medicine model library and a disease and therapeutic schememodel library, the execution modules include a training and evaluation selection module, a surgical stage selection module, a medical equipment and medicine selection module and a disease and therapeutic scheme selection module, and the training and evaluation selection module is sequentially connected with the surgical stage selection module, the medical equipment and medicine selection module and the disease and therapeutic scheme selection module. The surgical training and evaluation method has the advantages that surgical training and evaluation can be accomplished by the aid of virtual reality systems, therapeutic schemes can be verified and simulated by the aid of the virtual reality systems, evolution mechanisms of diseases can be observed by the aid of the virtual reality systems,and environment-friendly and safe modes can be provided to surgical skill training and evaluation and therapeutic scheme design emulation; the technical problems of low efficiency, severe waste and high surgical risks of existing surgical training and evaluation methods can be solved by the aid of the surgical training and evaluation method.
Owner:CHINA THREE GORGES UNIV

Chinese traditional medicine for treating fowl coccidiosis and the preparing method thereof

The invention discloses a Chinese medicinal preparation for treating avian coccidiosis and its preparing process, wherein the medicament is prepared from the following constituents (by weight portions): sweet wormwood 200-400g, dichroa febrifuga lour 200-400g, Chinese pulsatilla root 100-300g, astragalus root 100-300g. The preparing process for the product comprises the steps of weighing, poaching, drying, disintegrating, sieving, extracting, filtering, concentrating, flocculating setting, encapsulating and sterilizing.
Owner:天津市万格尔生物工程有限公司

Method and device for implanting and locating micro planting nail for orthodontics

The invention relates to a method for implanting and locating a micro planting nail for orthodontics. The method comprises the steps that an oral cavity to be implanted with the micro planting nail is subjected to CBCT (Cone Beam Computed Tomography); a three-dimensional reconstruction for an oral cavity structure is performed; a three-dimensional entity image model is formed; a micro planting nail model is imported into a computer; a preset planting position for the micro planting nail is determined; an occlusal plane plate is put in a mouth of a patient; a horizontal movable unit is arranged on the occlusal plane plate; a lifting and rotation unit connected with a planting gun guide tube is arranged on the movable unit; a vertical distance between the planting gun guide tube and the occlusal plane plate and a planting direction of the micro planting nail are determined; and a planting gun is finally connected with the planting gun guide tube for planting operation. The method has the benefits that the implantation precision of the micro planting nail can be improved effectively; an implantation falling-off rate of the micro planting nail is reduced; a good correction effect is achieved; the pain and the hospitalization cost of a patient can be relieved and reduced; and the clinical working time of a doctor is saved.
Owner:季骏

Novel light-emitting diode (LED) phototherapy health-care device

The invention relates to a novel light-emitting diode (LED) phototherapy health-care device. The novel LED phototherapy health-care device comprises a shell, a central control module, a keystroke module and a display module, wherein the central control module is installed inside the shell and is connected with the keystroke module and the display module, both of which are embedded on the shell; the central control module is connected with a controlled terminal of a power supply control module; an input terminal of the power supply control module is connected with mains supply; an output end of the power supply control module is connected with multiple sockets embedded on the shell; and a plug inserted in each socket is connected with an LED module embedded on a substrate through cables. In the novel LED phototherapy health-care device provided by the invention, a host is connected with multiple LED modules on the substrate, so that the single treatment function of the conventional equipment is solved; and the novel LED phototherapy health-care device can be used for the treatment of multiple diseases and different treatment stages of one disease, has good integral treatment effect, and is multifunctional medical treatment and prevention health-care equipment used clinically in hospitals and households in communities.
Owner:顾英 +2

Customized tongue side orthodontic bracket and manufacturing method thereof

The invention discloses a customized tongue side orthodontic bracket and a manufacturing method thereof. The tongue side orthodontic bracket comprises a bracket body commonly defined by a tooth direction surface and tongue direction surface, wherein a sunken part is formed in the middle region of the tongue direction surface of the bracket body, an upper wing and a lower wing are arranged in the sunken part and a groove is formed in the sunken part; a circular-arc-shaped outline is maintained among the tongue direction surface of the bracket body and the outer surfaces of the upper wing and the lower wing. The manufacturing method of the bracket comprises the main steps of establishing a virtual bracket body in a computer, setting a central line of the groove, acquiring a tooth arrangement model with ideal tooth rows, determining a virtual forming position of the groove, matching the central line of the groove with the virtual forming position of the groove, rotating the bracket body around the central line so as to regulate the position of the bracket body and the thickness of the bracket body, cutting the groove along the central line to obtain the bracket body with the groove, and finally generating the real bracket by virtue of 3D printing. The tongue direction surface of the whole bracket body is machined into a circular arc shape, so that the stimulation to a tongue of a patient can be greatly relieved, and the comfort level of the patient is increased.
Owner:GUANGZHOU RITON BIOMATERIAL

Macrophages membrane coated breast cancer targeted nanoparticles and preparation method thereof

The invention belongs to the field of pharmaceutical preparations, and relates to macrophages membrane coated breast cancer targeted nanoparticles and a preparation method thereof. The macrophage membrane coated paclitaxel-loaded nanoparticles are prepared into a paclitaxel-loaded nanometer medicine delivery system from paclitaxel, macrophage membranes, amphiphilic high molecular materials, an injection solvent and the like. The macrophage membrane coated medicine carrying nanoparticles are good in biocompatibility, simple in preparation method and uniform in nanoparticle size distribution. Tumor cells are actively recognized through biological molecules on the surface of the macrophage membranes, so that active collection of medicine-containing carriers to a tumor region is effectively increased, retention of the medicine-containing carriers in tumor tissue is increased, controllability of medicine release is realized, and the anti-tumor treatment effects of medicines are increased.
Owner:FUDAN UNIV

Solid bio-enzyme sludge dehydrant and preparation method thereof

The invention discloses a solid bio-enzyme sludge dehydrant and a preparation method thereof and belongs to the technical field of sludge dehydration. The solid bio-enzyme sludge dehydrant comprises the following raw materials by mass percent: 5-15% of pectinase, 5-16% of protease, 8-15% of lipase, 8-13% of cellulase, 5-8% of catalase, 1-9% of amylase, 2-6% of lysozyme, 4-13% of a coagulant aid and 20-35% of a solid filling material, wherein the total mass percent of the raw materials is 100%. The prepared solid bio-enzyme sludge dehydrant can greatly dehydrate sludge and greatly lower the running cost of sludge dehydration treatment, and the treated sludge can be directly used for composting, agricultural soil and back-filling or such treatment and disposal modes as incineration accordingto actual characteristics of different regions, and therefore, has a good popularization prospect.
Owner:福州晨翔环保工程有限公司

Muscle function training and correcting system

The invention relates to a muscle function training and correcting system which comprises a HE pad, wherein an upper lip bumper and an upper tongue bumper are fixedly connected above the HE pad; a lower lip bumper and a lower tongue bumper are fixedly connected below the HE pad. A tongue position indicating rod is arranged at the upper part of the upper tongue bumper and connected with a sensor; the upper tongue bumper is connected with a recording chip; the recording chip is connected with a wearing management module and a doctor end. The sensor is used for detecting the time and intensity of tongue touch and sending the information to the wearing management module. The recording chip comprises an induction module, a recording module and a communication module, wherein the induction module is used for detecting in real time the existence of saliva in oral cavity and transmitting the wearing time length and wearing time point information to the recording module. The recording module is used for receiving and recording the information of the induction module; the communication module is used for transferring the information to the wearing management module. The system provided by the invention realizes real-time monitoring and guidance of the wearing of a muscle function training device of a child patient by a doctor, and greatly improves the correction effect.
Owner:SICHUAN UNIV

Anorectal examination and drug administration device capable of achieving precise drug administration

The invention relates to an anorectal examination and drug administration device capable of achieving precise drug administration. The device comprises a fixed base disc, a rotating disc for adjustingthe expansion degree, N arc expansion plates for achieving anal expansion and a drug administration assembly for applying drugs on the affected part; the fixed base disc comprises a base plate, an outer cylinder covering the base plate and an annular disc arranged in the outer cylinder, the rotating disc comprises a circular cover and N control blocks arranged in the circular cover, and the drugadministration assembly comprises a plurality of drug administration insertion plates, a main drug delivery tube, branch drug delivery tubes and a multi-way valve. The anorectal examination and drug administration device has the advantages that not only can the expansion degree be adjusted according to different patients, but also local precise drug administration can be achieved for the patients,and the treatment effect is good.
Owner:THE FIRST AFFILIATED HOSPITAL OF HENAN UNIV OF SCI & TECH

Controlled drainage structure and method for emergency treatment of barrier lake

PendingCN109811729AReduce peak and flow ratesProlong the time of leakageBarrages/weirsControlled drainagePeak value
The invention relates to the technical field of emergency treatment of a barrier lake, in particular to a controlled drainage structure and method for emergency treatment of a barrier lake. The controlled drainage structure for emergency treatment of the barrier lake comprises a drainage channel and an anti-scouring structure, wherein the drainage channel is arranged on the middle lower portion ofa damming object in the water flow direction; and the anti-scouring structure is arranged in the drainage channel. When water of the barrier lake flows into the drainage channel, the anti-scouring structure obstructs the water flow in the drainage channel, the impact force of the water flow is reduced, the peak value and the flow speed of the water flow are effectively reduced, the burst time ofthe damming object caused by drainage scouring is prolonged, inundation height and scouring range along the lower reaches of the river are also reduced, damage and loss of the downstream are reduced as much as possible, and protection of a downstream ecological environment is improved. Visibly, according to the drainage structure and method for treatment of the barrier lake, the structure is simple, the treatment effect is good, the water quantity and flow speed of the drainage channel are controlled, and the safety of treatment of the barrier lake is improved remarkably.
Owner:HYDRAULIC SCI RES INST OF SICHUAN PROVINCE

Multifunctional cold-circulating bundling microwave treatment probe

The invention discloses a multifunctional cold-circulating bundling microwave treatment probe comprising an operating handle and a bundle, wherein the bundle consists of two ore more than two liquid medium strengthened hollow cooling microwave probes; the center of the bundle is provided with a multifunctional passage used for infusing a liquid medium or embedding a solid medium into a target tissue or carrying out temperature measurement or tissue biopsy; and the multifunctional passage and the bundle are fixed on the operating handle. The invention can outstandingly enlarge the melting volume of a microwave tissue and has a function of enhancing the treatment effect by infusing the liquid medium or embedding the solid medium into the target tissue and multiple functions, i.e. the biopsy, the temperature measurement, and the like.
Owner:苗毅
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