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184 results about "Tissue biopsy" patented technology

A tissue biopsy is a minor procedure to remove a small piece of tissue from the patient. This is examined under a microscope to check for known abnormalities, or used in other tests. In Batten disease, the most common type of biopsy is a skin biopsy.

Tissue biopsy and treatment apparatus and method

An embodiment of the invention provides a tissue biopsy and treatment apparatus that comprises an elongated delivery device that is positionable in tissue and includes a lumen. A sensor array having a plurality of resilient members is deployable from the elongated delivery device. At least one of the plurality of resilient members is positionable in the elongated delivery device in a compacted state and deployable with curvature into tissue from the elongated delivery device in a deployed state. At least one of the plurality of resilient members includes at least one of a sensor, a tissue piercing distal end or a lumen. The sensor array has a geometric configuration adapted to volumetrically sample tissue at a tissue site to differentiate or identify tissue at the target tissue site. At least one energy delivery device is coupled to one of the sensor array, at least one of the plurality of resilient members or the elongated delivery device.
Owner:ANGIODYNAMICS INC

Apparatus and method for harvesting and handling tissue samples for biopsy analysis

A sectional cassette (10) for use in a process for harvesting and handling tissue samples for biopsy analysis is disclosed. In the procedure, a tissue biopsy sample is placed on a tissue trapping supporting material (A′) that can withstand tissue preparation procedures, and which can be cut with a microtome. The tissue is immobilized on the material, and the material and the tissue are held in the cassette (10) subjected to a process for replacing tissue fluids with wax. The tissue and supporting material are sliced for mounting on slides using a microtome. Harvesting devices and containers (200) using the filter material (202) are disclosed. An automated process is also disclosed.
Owner:BIOPATH AUTOMATION

Tissue biopsy and treatment apparatus and method

A method of treating a tumor includes providing a tissue biopsy and treatment apparatus that includes an elongated delivery device that has a lumen and is maneuverable in tissue. A sensor array having a plurality of resilient members is deployable from the elongated delivery device. At least one of the plurality of resilient members is positionable in the elongated delivery device in a compacted state and deployable with curvature into tissue from the elongated delivery device in a deployed state. At least one of the plurality of resilient members includes at least one of a sensor, a tissue piercing distal end or a lumen. The sensor array has a geometric configuration adapted to volumetrically sample tissue at a tissue site to differentiate or identify tissue at the tissue site. At least one energy delivery device is coupled to one of the sensor array, at least one of the plurality of resilient members or the elongated delivery device. The apparatus is then introduced into a target tissue site. The sensor array is then utilized to distinguish a tissue type. The tissue type information derived from the sensor array is utilized to position the energy delivery device to ablate a tumor volume. Energy is then delivered from the energy delivery device to ablate or necrose at least a portion of the tumor volume. The sensor array is then utilized to determine an amount of tumor volume ablation.
Owner:ANGIODYNAMICS INC

Tissue biopsy and processing device

A tissue biopsy and processing device for capturing and processing a tissue sample is provided. In general, the device includes a biopsy member adapted to remove a tissue sample from a patient's body, and a processing apparatus adapted to receive the tissue sample from the biopsy device, and to dissociate and mince the tissue sample in preparation for further use. The processing apparatus can include a tissue reducing chamber in communication with and adapted to receive the tissue sample from the biopsy member, and a tissue processing element associated with the tissue reducing chamber that is effective to dissociate the tissue sample retained within the tissue reducing chamber.
Owner:DEPUY SYNTHES PROD INC

Tissue biopsy and treatment apparatus and method

A method of treating a tumor includes providing a tissue biopsy and treatment apparatus that includes an elongated delivery device that has a lumen and is maneuverable in tissue. A sensor array having a plurality of resilient members is deployable from the elongated delivery device. At least one of the plurality of resilient members is positionable in the elongated delivery device in a compacted state and deployable with curvature into tissue from the elongated delivery device in a deployed state. At least one of the plurality of resilient members includes at least one of a sensor, a tissue piercing distal end or a lumen. The sensor array has a geometric configuration adapted to volumetrically sample tissue at a tissue site to differentiate or identify tissue at the tissue site. At least one energy delivery device is coupled to one of the sensor array, at least one of the plurality of resilient members or the elongated delivery device. The apparatus is then introduced into a target tissue site. The sensor array is then utilized to distinguish a tissue type. The tissue type information derived from the sensor array is utilized to position the energy delivery device to ablate a tumor volume. Energy is then delivered from the energy delivery device to ablate or necrose at least a portion of the tumor volume. The sensor array is then utilized to determine an amount of tumor volume ablation.
Owner:ANGIODYNAMICS INC

Apparatus and method for harvesting and handling tissue samples for biopsy analysis

A sectionable cassette for use in a process for harvesting and handling tissue samples for biopsy analysis is disclosed. In the procedure, a tissue biopsy sample is placed on a tissue trapping and supporting material that can withstand tissue preparation procedures and which can be cut with a microtome. The tissue is immobilized on the material and the material and the tissue are held in the cassette and are subjected to a process for replacing tissue fluids with wax, and then the tissue and the supporting material are sliced for mounting on slides using a microtome. Harvesting devices and containers using the filter material are disclosed. An automated process is also disclosed. One embodiment has the tissue trapping and supporting material porous and another embodiment includes a tissue supporting material that is not easily microtomed.
Owner:BIOPATH AUTOMATION

Graphical user interface for tissue biopsy system

A graphical user interface is disclosed for a tissue biopsy system having a tissue cutting member adapted for cutting one or more tissue specimens from tissue at a target site within a patient. The graphical user interface includes a first GUI area representing a first region of the target site from which the tissue cutting member has separated one or more tissue specimens. The graphical user interface further includes a second GUI area, visually distinguishable from the first GUI area, representing a second region from which the tissue cutting member may separate one or more additional tissue specimens from tissue at the target site.
Owner:SENORX

Immunogenic compositions to the CCK-B/gastrin receptor and methods for the treatment of tumors

InactiveUS6548066B1Inhibiting autocrine growth-stimulatory pathwayEffectively prevent the binding of the peptide hormones to the receptorsPeptide/protein ingredientsReceptors for hormonesTissue biopsyPassive Immunizations
The invention concerns immunogens, immunogenic compositions and method for the treatment of gastrin-dependent tumors. The immunogens comprise a peptide from the CCK-B / gastrin-receptor conjugated to a spacer and to an immunogenic carrier. The immunogens are capable of inducing antibodies in vivo which bind to the CCK-B / gastrin-receptor in tumor cells, thereby preventing growth stimulating peptide hormones from binding to the receptors, and inhibiting tumor cell growth. The immunogens also comprise antibodies against the CCK-B / gastrin-receptor for passive immunization. The invention also concerns diagnostic methods for detecting gastrin-dependent tumors in vivo or from a tissue biopsy using the antibodies of the invention.
Owner:CANCER ADVANCES INC

Automated biopsy and delivery device

An automated device and method for obtaining a tissue biopsy and the delivery of a material to provide hemostatis, therapeutic agents or marker material is described that can be used in conjunction with a cutting needle biopsy device. The device has an outer casing, a power source, a drive mechanism, an application chamber through which the biopsy mechanism, typically a cutting needle device, passes through and an application channel. The cutting biopsy mechanism has a mechanical or electromechanical mechanism to rapidly fire a stylet with a biopsy trough into the intended tissue and then rapidly propel a biopsy cannula over the stylet to sever and retain tissue that has protruded into the biopsy trough. At least one application channel is formed by a tube centrically slipped over the biopsy cannula wall. To enable the collection of tissue specimens, the distal segment of the application channel forms a close fitting and concentric sheath around the biopsy cannula. The biopsy cannula wall projects out of the tube with its acute-angularly designed cutting edge and the tube end encloses an obtuse angle with the biopsy cannula. The proximal end of the application channel has a larger diameter than the distal end allowing for unobstructed flow of the application material past the biopsy cannula wall upon retraction of the biopsy cannula from the distal segment of the application channel. The drive mechanism contains holders for placement of the application chamber and the biopsy mechanism and a method to manipulate the proper sequence and movement of the two.
Owner:BIOENG CONSULTANTS LTD

Cell and tissue collection method and device

In an embodiment of the invention, a frictional tissue sampling device with an expandable balloon and associated abrasive material can be used to obtain tissue biopsy samples. A frictional tissue sampling device with expandable abrasive material can be used to obtain an epithelial tissue biopsy sample from lesions. The device can be otherwise used to sample specific locations. In various embodiments, the head of the device can be passes through a catheter into a body canal to sample epithelial tissue.
Owner:HISTOLOGICS

Ratio based biomarkers and methods of use thereof

Compositions, methods and kits are described for identifying biomolecules (e.g., proteins and nucleic acids) expressed in a biological sample that are associated with the presence, development, or progression of a disease (such as cancer), or more generally determination of the etiology or risk factors associated with a disease. Sample types analyzed by the disclosed methods include but are not limited to archival tissue blocks that have been preserved in a fixative, tissue biopsy samples, tissue microarrays, and so forth. The methods disclosed herein correlate expression profiles of biomolecules with various disease types, and allow for the determination of relative survival rates; in some embodiments, the methods permit determination of survival rates for a subject with cancer. In other embodiments, the disclosure relates to methods for evaluating therapeutic regimes for the treatment, such as treatment of cancer.
Owner:UNITED STATES OF AMERICA

Automated histological diagnosis of bacterial infection using image analysis

The invention relates to an automated decision support system, method, and apparatus for analysis and detection of bacteria in histological sections from tissue biopsies in general, and more specifically, of Helicobacter pylori (HP) in histological sections from gastric biopsies. The method includes image acquisition apparatus, data processing and support system conclusions, methods of transferring and storing the slide data, and pathologist diagnosis by reviewing and approving the images classified as containing bacteria, and more specifically HP findings.
Owner:PANGEA DIAGNOSTICS

System and method for performing a full thickness tissue biopsy

A medical system for performing a tissue biopsy at a remote location within a patient is disclosed. The medical system comprises an elongate outer cutting member, an elongate inner member movably disposed within the outer member, and a tissue traction member for anchoring bodily tissue and pulling a sample of the tissue within the outer cutting member.
Owner:COOK MEDICAL TECH LLC

Genotyping by in situ PCR amplification of a polynucleotide in a tissue biopsy

Reagents and method for genotyping mice and other animals by in situ Polymerase Chain Reaction amplification of a target polynucleotide in the tissue biopsy. The reagent is comprised of non-ionic detergents, a protease, a buffering agent, a metal ion cofactor, a chelating agent and a salt. The method is comprised of taking a tissue biopsy; admixing it with the reagent; a Lysing Cycle, an inactivation cycle, an amplification step and a detection step.
Owner:KWON JAI W

System and method for tissue biopsy using ultrasonic imaging

A tissue biopsy device uses ultrasonic imaging to guide the biopsy needle. An ultrasonic imaging device comprises three acoustically coupled chambers with an ultrasound transducer in a first chamber, at least a portion of an ultrasound detector in the second chamber and the portion of patient anatomy to be imaged placed in the third chamber, which is intermediate the first and second chambers. The three chambers are filled with an acoustically transmissive liquid. One or more of the end walls dividing the first and third chambers and second and third chambers may be movable to form compression plates that are used to retain the patient anatomy in a fixed position during the imaging and biopsy process. When a structure, such as a lesion, has been located, the imaging may be used to determine the precise location of the lesion in three dimensions. The ultrasonically transmissive fluid is drained from the central third chamber with ultrasonic coupling occurring through the ultrasonically transmissive compression plates and the imaged patient anatomy. This permits real-time imaging of the patient anatomy during the biopsy process. The three-dimensional coordinates are used to provide a manual guide for insertion of the biopsy needle. Light bars may be projected onto the external anatomy of the patient to indicate the desired point of entry of the biopsy needle. The physician may use the real-time imaging to view both the lesion and the biopsy needle. In an alternative embodiment, a biopsy needle may be automatically positioned at the location of the lesion by a three-dimensional positioning system.
Owner:ADVANCED IMAGING TECH

Reusable Tissue Biopsy Kit with Padded Cassette

An improved biopsy kit for the collection, storage, transportation, and processing of biopsy tissue samples is disclosed. The disclosed biopsy kit consists of a typical specimen container and an improved tissue cassette with adhesively attached polyvinyl alcohol foam pads on both the base and lid portions. An excised tissue sample is sandwiched between the pads upon cassette closure, simultaneously isolating and securing the sample in its original orientation. Superior wicking, absorbency, and moisture retention rate of these polyvinyl alcohol pads allows maximum tissue fixation as well as maintains sample integrity. Once the tissue is placed by the physician at the patient's side, it remains there until the tissue is ready to be processed. This eliminates transfer errors as well as tissue loss.
Owner:DESAI VIRENDRA +1

Method for expansion of epithelial stem cells

InactiveUS7347876B2Expand the populationEye implantsTissue cultureComposite Tissue AllograftTissue biopsy
Transplantation of epithelial stem cells, cultured ex vivo on specifically treated amniotic membrane, yields, with that amniotic membrane, a surgical graft having expanded epithelial stem cells. The method of creating this graft and the graft itself are simple and effective to reconstruct damaged tissue, a preferred example being corneal tissue. The source of the epithelial stem cells can be a very small explant from healthy autologous and allogeneic tissue biopsy. The amniotic membrane is treated such that its extracellular matrix is maintained, but its cells are killed.
Owner:TSAI RAY JUI FANG

Frictional trans-epithelial tissue disruption collection apparatus and method of inducing an immune response

In an embodiment of the invention, a frictional tissue sampling device with a head designed to be rotated without rotating off the designated site can be used to obtain tissue biopsy samples. A frictional tissue sampling device with a head designed to be rotated without rotating off the designated site can be used to obtain an epithelial tissue biopsy sample from lesions. The device can be otherwise used to sample specific locations. In various embodiments, the head of the device is narrow and pointed with a hybrid pear shaped diamond facet. Abrasive material can be adhered to the facet.
Owner:HISTOLOGICS

Biopsy forceps

A biopsy forceps and method of using the biopsy forceps. The biopsy forceps includes a plurality of grasping members extending from an inner shaft. The plurality of grasping members are biased toward an open configuration. Sliding a sheath over the grasping members constrains the grasping members to a closed configuration. A method of performing a tissue biopsy is also disclosed.
Owner:WILSONCOOK MEDICAL

Apparatus and method for tissue biopsy

Exemplary embodiments of an apparatus can be provided for obtaining portions or samples of tissue from a target region of a biological tissue. One or more needles can be provided that have a small internal diameter, e.g., about 1 mm or less, and the needles can be configured to extract the tissue portions when the needles are inserted into and withdrawn from the tissue. Windows and / or markings can be provided on the wall of the needles to facilitate access to the sample. The needles can be provided in an enclosure, and an actuator can be provided to direct the needles into the tissue and / or withdraw them. A plurality of tissue portions having known relative locations in the target region can be obtained, and extraction of the tissue portions can be well-tolerated by the tissue as compared with conventional punch biopsies or the like.
Owner:THE GENERAL HOSPITAL CORP

Biopsy needle system, biopsy needle and method for obtaining a tissue biopsy specimen

A biopsy needle system includes a carrier. A trocar is inserted into the carrier for percutaneous insertion to a biopsy site. A biopsy needle is inserted into the carrier, replacing the trocar, for removal of a tissue biopsy specimen. A biopsy needle and a method for obtaining a tissue biopsy specimen with the system, are also provided.
Owner:MCCLELLAN W THOMAS

Method For Providing Dna Fragments Derived From An Archived Sample

Aspects of the present invention relate to compositions and methods for providing DNA fragments from an archived sample (e.g., paraffin-embedded and / or fixed-tissue biopsies, etc). Particular aspects provide methods whereby high yields of DNA are isolated as well as a substantial portion of the DNA consists of long DNA fragments, and where the isolated genomic DNA is free of associated or cross-linked contaminants like proteins, peptides, amino acids or RNA. The methods are facile, cost-effective, an are characterized by high reproducibility and reliability. Particular aspects provide methods for providing DNA fragments derived from an archived sample, wherein the yield of DNA before, for example, an amplification step is at least 20%, and amplicons up to a length of about 1,000 base pairs are amplifiable.
Owner:EPIGENOMICS AG

Cardiac stem cell populations for repair of cardiac tissue

Method for the isolation, expansion and preservation of cardiac stem cells from human or animal tissue biopsy samples to be employed in cell transplantation and functional repair of the myocardium or other organs. Cells may also be used in gene therapy for treating cardiomyopathies, for treating ischemic heart diseases and for setting in vitro models to study drugs.
Owner:UNIV DEGLI STUDI DI ROMA LA SAPIENZA

Tissue biopsy needle apparatus

The present invention is intended to provide a tissue biopsy needle apparatus equipped with a protective cover which prevents a needle tube from being ejected unnecessarily when an urging member is compressed in preparation for ejection of the needle tube. For that, the tissue biopsy needle apparatus includes a spring 28 which ejects the needle tube 26; a drawing unit which draws the spring 28 to a compressed position, the drawing unit including a drawing knob 20 and a drawing tube 29; an operation switch 24 which causes the drawing unit to draw and hold the spring 28 at the compressed position and causes the spring 28 to be released from the compressed position, thereby ejecting the needle tube 26; a protective cover 23 which disables the operation switch 24 when the spring 28 is drawn and held at the compressed position; and an elastic tongue 23c and an abutting strip29b which move the protective cover 23 from a working position to a non-working position of the operation switch 24 in accordance with drawing of the spring 28 to the compressed position by the drawing unit, the elastic tongue 23c being installed on the protective cover and the abutting strip 29b being installed on the drawing tube 29.
Owner:OLYMPUS MEDICAL SYST CORP

Method for expansion of epithelial stem cells

InactiveUS20030208266A1Promote epithelializationReduce inflammationEye implantsTissue biopsyComposite Tissue Allograft
Transplantation of epithelial stem cells, cultured ex vivo on specifically treated amniotic membrane, yields, with that amniotic membrane, a surgical graft having expanded epithelial stem cells. The method of creating this graft and the graft itself provide simple and effective means to reconstruct damaged tissue, a preferred example being corneal tissue. The source of the epithelial stem cells can be a very small explant from healthy autologous and allogeneic tissue biopsy. The amniotic membrane is treated such that its extracellular matrix is maintained, but its cells are killed.
Owner:TSAI RAY JUI FANG

Bioreactor for cell and tissue culture

The present invention provides a bioreacto 1r for incubation of cell cultures, tissue biopsies, cell clusters, tissue-like structures, ‘prototissues’ or similar samples. The bioreactor is generally adapted for rotation for use in microgravity conditions and equipped with an incubation cavity having a small internal fluid volume, generally less than 1 ml. To avoid problems associated with small volume incubation, the bioreactor may include a humidity chamber or other means of avoiding dehydration as well as substantially fluid-tight closures for access ports that avoid introduction of air bubbles to the incubation cavity. The small-volume bioreactor permits long term maintenance of tissue differentiation states in cultures. Also provided are methods of incubating cells or tissues using the bioreactor including methods of creating molecular profiles of biological effects of chemical compositions on differentiated cell or tissue samples maintained in long term culture.
Owner:DRUGMODE APS

Systems and methods for processing tissue samples for histopathology

A system for processing tissue biopsy samples during a histopathology process, including a tissue carrier (40) constructed to carry a tissue biopsy sample (54) during at least one step of the histopathology process, a database storing information associated with the tissue biopsy sample and associated with a tissue processing procedure, a machine-readable indicator (50) physically associated with the tissue carrier (40), the machine-readable indicator (50) including a machine- readable reference identified with the tissue biopsy sample (54), and an electronic control (48) operative to read the reference, access the information in the database using the reference, and implement at least a portion of the tissue processing procedure in accordance with the accessed information.
Owner:BIOPATH AUTOMATION

Non-seeding biopsy device and method

Tissue biopsy is performed through a central passage of a cannula covered with a protective sleeve. The protective sleeve is attached at one end to a location at or near a distal end of the cannula. After the biopsy procedure is completed, the cannula is withdrawn so that its exterior slides through the sleeve. In this way, the trailing edge of the sleeve is invaginated within the proximal portions of the itself to envelop the sleeve exterior and reduce the risk of inadvertent tumor cell seeding.
Owner:PERCUTANEOUS SYST

Unicell based immunocyte typing quantitative analysis method

The invention provides a unicell based immunocyte typing quantitative analysis method. The method comprises that (1) a blood sample or a focus tissue biopsy sample of a patient is collected; (2) an antibody labeled with metal elements is used to mark cells of the sample with multiple targets at the same time; (3) the marked cell sample is detected by a mass spectrum flow type detection system; (4)on the basis of the obtained mass spectrum flow type detection data, different immunocyte subgroups are clustered for analysis, and the expression level of the different subgroup cells in a tumor immune target is quantitatively analyzed; and (5) after data processing and calculation of a dimension reducing algorithm, a 2D point diagram, a SPADE graph or a thermograph are drafted, data is displayed in a visualized way, and an informatics analysis model is constructed to cluster and analyze the different immunocyte subgroups. The rare immunocyte groups and antigen with lower expression are detected sensitively by high-flux analysis detection, the immunization typing analysis is more accurate, and the method has prospects of clinical application.
Owner:TAIZHOU POLARIS BIOLOGY CO LTD
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