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In accordance with the invention, a low coherence interferometer is used to non-invasively monitor the concentration of glucose in blood by shining a light over a surface area of human or animal tissue, continuously scanning the light over a two dimensional area of the surface, collecting the reflected light from within the tissue and constructively interfering this reflected light with light reflected along a reference path to scan the tissue in depth. Since the reflection spectrum is sensitive to glucose concentration at particular wavelengths, measurement and analysis of the reflected light provides a measure of the level of glucose in the blood. The measurement of glucose is taken from multiple depths within blood-profused tissue, and sensitivity is preferably enhanced by the use of multiple wavelengths. Noise or speckle associated with this technique is minimized by continuously scanning the illuminated tissue in area and depth.

An intervertebral disc space implant includes spaced-apart bone engagement portions that define an intermediate chamber that holds bone growth inducing material into contact with adjacent vertebral bodies. The implant is expandable to establish and maintain desired intervertebral spacing during fusion. The implant includes a first member and a second member arranged to move relative to each other by action of an expansion member, the first member being engageable with the vertebral body below the disc space.

An intervertebral disc space implant includes spaced-apart bone engagement portions that define an intermediate chamber that holds bone growth inducing material into contact with adjacent vertebral bodies. The implant is expandable to establish and maintain desired intervertebral spacing during fusion. The implant includes a first member and a second member arranged to move relative to each other by action of an expansion member, the first member being engageable with the vertebral body below the disc space.

A variety of methods and arrangements for improving the fuel efficiency of internal combustion engines are described. Generally, selected combustion events are skipped during operation of the internal combustion engine so that other working cycles can operate at a better thermodynamic efficiency. In one aspect of the invention, an engine is controlled to operate in a variable displacement mode. In the variable displacement mode, fuel is not delivered to the working chambers (e.g. cylinders) during selected “skipped” working cycles. During active (“non-skipped”) working cycles, a maximum (e.g., unthrottled) amount of air and an optimized amount of fuel is delivered to the relevant working chambers so that the fired working chambers can operate at efficiencies closer to their optimal efficiency. A controller is used to dynamically determine the chamber firings required to provide the engine torque based on the engine's current operational state and conditions. The chamber firings may be sequenced in real time or in near real time in a manner that helps reduce undesirable vibrations of the engine.

An optical imaging system comprising: a taking lens system that collects light from a scene being imaged with the optical imaging system; a 3D camera comprising at least one photosurface that receives light from the taking lens system simultaneously from all points in the scene and provides data for generating a depth map of the scene responsive to the light; and an imaging camera comprising at least one photosurface that receives light from the taking lens system and provides a picture of the scene responsive to the light.

A spinal mobility preservation apparatus and methods are disclosed. The spinal mobility preservation apparatus may include a proximal body, an intermediate body, a distal body, and an expandable membrane. The proximal body and the distal body secure the mobility preservation apparatus to adjacent vertebral bodies. At least one of an intermediate body and an expandable membrane secure the proximal body to the distal body and provide a degree of support to a spinal motion segment defined by the adjacent vertebral bodies. A single proximal body and an expandable membrane may also compose a spinal mobility preservation apparatus. The proximal body secured to one of a superior or an inferior vertebral body and the expandable membrane extending into the intervertebral disc space to support the spinal motion segment.

A tool-carrying catheter, comprising: an elongate body adapted for insertion into a blood vessel; a tool section attached to a distal side of said body; and a guide-channel adapted to carry at least a guide-wire, wherein said catheter includes an entry port into said guide-channel for said guide wire and wherein said tool includes a distal exit for said guide wire from said guide-channel, defined in a side of said tool.

A variety of methods and arrangements for improving the fuel efficiency of internal combustion engines are described. Generally, selected combustion events are skipped during operation of the internal combustion engine so that other working cycles can operate at a better thermodynamic efficiency. In one aspect of the invention, an engine is controlled to operate in a variable displacement mode. In the variable displacement mode, fuel is not delivered to the working chambers (e.g. cylinders) during selected “skipped” working cycles. During active (“non-skipped”) working cycles, a maximum (e.g., unthrottled) amount of air and an optimized amount of fuel is delivered to the relevant working chambers so that the fired working chambers can operate at efficiencies closer to their optimal efficiency. A controller is used to dynamically determine the chamber firings required to provide the engine torque based on the engine's current operational state and conditions. The chamber firings may be sequenced in real time or in near real time in a manner that helps reduce undesirable vibrations of the engine.

A method and system for performing optical proximity correction (OPC) on an integrated circuit (IC) chip design is disclosed. The system and method of the present invention includes dividing the IC chip into a plurality of local task regions, identifying congruent local task regions, classifying congruent local task regions into corresponding groups, and performing OPC for each group of congruent local task regions.By identifying and grouping congruent local task regions in the IC chip, according to the method and system disclosed herein, only one OPC procedure (e.g., evaluation and correction) needs to be performed per group of congruent local task regions. The amount of data to be evaluated and the number of corrections performed is greatly reduced because OPC is not performed on repetitive portions of the IC chip design, thereby resulting in significant savings in computing resources and time.

A photovoltaic powering system is provided that includes a movable platform connected to a self-propelled vehicle. An array of one or more photovoltaic cells is carried by the movable platform. A platform movement mechanism carried by the vehicle moves the movable platform. A platform alignment module carried by the vehicle and connected to the platform movement mechanism causes the photovoltaic cells to be aligned relative to ambient sunlight. The one or more photovoltaic cells converts ambient sunlight to energy that is supplied to a battery carried by the vehicle to thereby recharge the battery if a charge associated with the battery is less than a predetermined threshold.

Disclosed are surgical tools, tool sets and methods for percutaneously accessing and preparing treatment sites within the spine for subsequent treatment procedures. The treatment site may be an inter-vertebral motion segments in the lumbar and sacral regions of the spine. The tool set may comprise introducer tools and bone dilators for accessing and tapping into a targeted site, such as, for example, the anterior surface of the S1 vertebral body. The tool set may also comprise cutters and extractors for preparing the treatment site for subsequent treatment procedures. The tool set may additionally comprise a bone graft inserter, an exchange system, and / or a temporary distraction tool for further preparing the treatment site for subsequent treatment procedures.

An omnidirectional sensor array system, for example a panoptic camera, comprising a plurality of sensors arranged on a support of predetermined shape to acquire data, wherein said sensors are directional and wherein each sensor is attached to a processing node which comprises integrated electronics that carries out at least a portion of the signal processing algorithms locally in order to reduce the computational load of a central hardware unit.

A III-nitride optoelectronic device comprising a light emitting diode (LED) or laser diode with a peak emission wavelength longer than 500 nm. The III-nitride device has a dislocation density, originating from interfaces between an indium containing well layer and barrier layers, less than 9×109 cm−2. The III-nitride device is grown with an interruption time, between growth of the well layer and barrier layers, of more than 1 minute.

The present invention is directed to a methods and compositions for receptor mediated drug delivery, particularly across the blood-brain barrier.

A system and method for enhancing the performance of wideband digital RF transport systems is disclosed, which enables the transport of different bandwidth segments on a plurality of wideband channels by selecting an optimal clock sample rate for each bandwidth segment to be transported. Thus, the bandwidth segments are proportionally allocated so that an optimum amount of bandwidth can be transported at the serial bit rate.

Disclosed are surgical tools, tool sets and methods for percutaneously accessing and preparing treatment sites within the spine for subsequent treatment procedures. The treatment site may be an inter-vertebral motion segments in the lumbar and sacral regions of the spine. The tool set may comprise introducer tools and bone dilators for accessing and tapping into a targeted site, such as, for example, the anterior surface of the S1 vertebral body. The tool set may also comprise cutters and extractors for preparing the treatment site for subsequent treatment procedures. The tool set may additionally comprise a bone graft inserter, an exchange system, and / or a temporary distraction tool for further preparing the treatment site for subsequent treatment procedures.

Systems and methods for enhancing knowledge discovery from data using multiple learning machines in general and multiple support vector machines in particular. Training data for a learning machine is pre-processed in order to add meaning thereto. Multiple support vector machines, each comprising distinct kernels, are trained with the pre-processed training data and are tested with test data that is pre-processed in the same manner. The test outputs from multiple support vector machines are compared in order to determine which of the test outputs if any represents a optimal solution. Selection of one or more kernels may be adjusted and one or more support vector machines may be retrained and retested. Optimal solutions based on distinct input data sets may be combined to form a new input data set to be input into one or more additional support vector machine. The methods, systems and devices of the present invention comprise use of Support Vector Machines for the identification of patterns that are important for medical diagnosis, prognosis and treatment. Such patterns may be found in many different datasets. The present invention also comprises methods and compositions for the treatment and diagnosis of medical conditions.

A method for forming an implantable medical device, such as a stent, is provided, in which electric discharges are applied to a metal surface of the implantable medical device. The electric discharges pit the surface. The pitted surface improves retention of a coating on the device and increases the amount of coating that can be carried by the device. An electric discharge machining process is described for applying electric discharges to the surface of the implantable medical device or portion thereof.

The present invention relates to a method and apparatus for creating steam from the cooling stream of a proton exchange membrane (PEM) fuel cell. As the cooling stream exits the PEM fuel cell, a portion of the cooling fluid is extracted from the circulating cooling stream, thereby creating a secondary stream of cooling fluid. This secondary stream passes through a restriction, which decreases the pressure of the secondary stream to its saturation pressure, such that when the secondary stream enters a flash evaporator it transforms into steam. Creating steam from the cooling stream of a PEM fuel cell power plant provides the fuel processor with a co-generated source of steam without adding a significant amount of auxiliary equipment to the power plant.

A sensor for blood component analysis that can correct the effect of a hematocrit easily is provided. The sensor includes an analysis portion including a working electrode, a counter electrode, and a reagent portion. The reagent portion includes an oxidoreductase that reacts with the blood component and a mediator, and the blood component is measured by causing a redox reaction between the blood component and the oxidoreductase in the presence of the mediator and detecting a redox current generated by the redox reaction by the working electrode and the counter electrode. In this sensor, the reagent portion further includes a hemolyzing agent (e.g., sodium cholate) for hemolyzing an erythrocyte, and when detecting the redox current, the erythrocyte is hemolyzed with the hemolyzing agent so as to cause hemoglobin released to an outside of the erythrocyte to react with the mediator and a current generated by this reaction also is detected to correct an effect of a hematocrit.

Disclosed are surgical tools, tool sets and methods for percutaneously accessing and preparing treatment sites within the spine for subsequent treatment procedures. The treatment site may be an inter-vertebral motion segments in the lumbar and sacral regions of the spine. The tool set may comprise introducer tools and bone dilators for accessing and tapping into a targeted site, such as, for example, the anterior surface of the S1 vertebral body. The tool set may also comprise cutters and extractors for preparing the treatment site for subsequent treatment procedures. The tool set may additionally comprise a bone graft inserter, an exchange system, and / or a temporary distraction tool for further preparing the treatment site for subsequent treatment procedures.

A fine particle producing process introduces a material for producing fine particles into a thermal plasma flame to make a vapor-phase mixture and quenches the vapor-phase mixture to form the fine particles. In the process, the material for producing the fine particles is dispersed or dissolved in a dispersion medium or solvent, preferably containing a combustible material to prepare a dispersion such as a slurry, a colloidal solution or a dissolution solution, the dispersion is made into a form of droplets, or the material for producing the fine particles is dispersed with a carrier gas and a combustible material and the dispersion in a droplet form or the dispersed material is introduced into the thermal plasma flame. In the fine particle producing process and apparatus, a gas of an amount sufficient to quench the vapor-phase mixture is supplied toward a tail of the thermal plasma flame. In the process and apparatus, primary fine particles are introduced into a cyclone to be subjected to cooling and classification and secondary fine particles having a particle size of 100 nm or less which are left upon removal of coarse particles are recovered.

In accordance with the invention, a low coherence interferometer is used to non-invasively monitor the concentration of glucose in blood by shining a light over a surface area of human or animal tissue, continuously scanning the light over a two dimensional area of the surface, collecting the reflected light from within the tissue and constructively interfering this reflected light with light reflected along a reference path to scan the tissue in depth. Since the reflection spectrum is sensitive to glucose concentration at particular wavelengths, measurement and analysis of the reflected light provides a measure of the level of glucose in the blood. The measurement of glucose is taken from multiple depths within blood-profused tissue, and sensitivity is preferably enhanced by the use of multiple wavelengths. Noise or speckle associated with this technique is minimized by continuously scanning the illuminated tissue in area and depth.

A multifocal diffractive lens comprises a multifocal diffractive structure coupled to a refractive component. The refractive component comprises at least one curved surface. The multifocal diffractive structure comprises a first plurality of substantially monofocal echellettes having a first optical power for near vision correction and a second plurality of substantially monofocal echellettes for far vision correction. The first plurality of substantially monofocal echellettes combined with the second plurality of substantially monofocal echellettes can provide a multifocal diffractive profile having decreased light scatter, chromatic aberration, and diffraction to non-viewing orders such that dysphotopsia is substantially inhibited. A third plurality of substantially monofocal echellettes having an intermediate optical power can be combined with the first plurality of substantially monofocal echellettes and the second plurality of substantially monofocal echellettes.

This invention provides compounds of conjugates of therapeutic or active agents with RAP or a RAP polypeptide, their pharmaceutical compositions and methods for using the such compounds and compositions in the diagnosis, prophylaxis, or treatment of diseases and conditions, including particularly diseases of the central nervous system or lysosomal storage diseases.

An instrument is provided which is in electronic communication with an on board diagnostic system (OBD) of an automobile. The instrument selectively queries the OBD with batch requests for the purpose of reducing a processing load placed on the OBD PCM. The instrument obtains numerous operating conditions through the OBD, and displays the operating conditions in an intuitive format. The operating conditions may be grouped into five different modes, and the five most relevant operating conditions within each mode may be displayed on the monitor either by default or through customization by the user.

A system, method and computer program product for synchronizing replicas of shared data structures associated with one or more computer systems. The method comprises: evaluating a metric for performing a replica synchronization operation on a first computer system according to a first synchronization method; evaluating the metric for performing a replica synchronization operation on the first computer system according to a second synchronization method; and, selecting, at synchronization time, based on the evaluated metric, whether to use the first or second synchronization methods, and communicating a command to a second computer system to replicate a shared data structure based on the selected synchronization method.