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In accordance with the invention, a low coherence interferometer is used to non-invasively monitor the concentration of glucose in blood by shining a light over a surface area of human or animal tissue, continuously scanning the light over a two dimensional area of the surface, collecting the reflected light from within the tissue and constructively interfering this reflected light with light reflected along a reference path to scan the tissue in depth. Since the reflection spectrum is sensitive to glucose concentration at particular wavelengths, measurement and analysis of the reflected light provides a measure of the level of glucose in the blood. The measurement of glucose is taken from multiple depths within blood-profused tissue, and sensitivity is preferably enhanced by the use of multiple wavelengths. Noise or speckle associated with this technique is minimized by continuously scanning the illuminated tissue in area and depth.

An intervertebral disc space implant includes spaced-apart bone engagement portions that define an intermediate chamber that holds bone growth inducing material into contact with adjacent vertebral bodies. The implant is expandable to establish and maintain desired intervertebral spacing during fusion. The implant includes a first member and a second member arranged to move relative to each other by action of an expansion member, the first member being engageable with the vertebral body below the disc space.

A variety of methods and arrangements for improving the fuel efficiency of internal combustion engines are described. Generally, selected combustion events are skipped during operation of the internal combustion engine so that other working cycles can operate at a better thermodynamic efficiency. In one aspect of the invention, an engine is controlled to operate in a variable displacement mode. In the variable displacement mode, fuel is not delivered to the working chambers (e.g. cylinders) during selected “skipped” working cycles. During active (“non-skipped”) working cycles, a maximum (e.g., unthrottled) amount of air and an optimized amount of fuel is delivered to the relevant working chambers so that the fired working chambers can operate at efficiencies closer to their optimal efficiency. A controller is used to dynamically determine the chamber firings required to provide the engine torque based on the engine's current operational state and conditions. The chamber firings may be sequenced in real time or in near real time in a manner that helps reduce undesirable vibrations of the engine.

Disclosed are surgical tools, tool sets and methods for percutaneously accessing and preparing treatment sites within the spine for subsequent treatment procedures. The treatment site may be an inter-vertebral motion segments in the lumbar and sacral regions of the spine. The tool set may comprise introducer tools and bone dilators for accessing and tapping into a targeted site, such as, for example, the anterior surface of the S1 vertebral body. The tool set may also comprise cutters and extractors for preparing the treatment site for subsequent treatment procedures. The tool set may additionally comprise a bone graft inserter, an exchange system, and / or a temporary distraction tool for further preparing the treatment site for subsequent treatment procedures.

External energy source, external charger, system of transcutaneous energy transfer, system of transcutaneous charging and method thereof. An implantable medical device has a secondary coil operatively coupled to therapeutic componentry. An external power source has a housing, a primary coil carried in the housing with the primary coil being capable of inductively energizing the secondary coil when the housing is externally placed in proximity of the secondary coil with a first surface of the housing positioned closest to the secondary coil and a thermo-electric cooling device placed associated with the first surface of the housing.

The present invention is directed to a methods and compositions for receptor mediated drug delivery, particularly across the blood-brain barrier.

A system and method for enhancing the performance of wideband digital RF transport systems is disclosed, which enables the transport of different bandwidth segments on a plurality of wideband channels by selecting an optimal clock sample rate for each bandwidth segment to be transported. Thus, the bandwidth segments are proportionally allocated so that an optimum amount of bandwidth can be transported at the serial bit rate.

In accordance with the invention, a low coherence interferometer is used to non-invasively monitor the concentration of glucose in blood by shining a light over a surface area of human or animal tissue, continuously scanning the light over a two dimensional area of the surface, collecting the reflected light from within the tissue and constructively interfering this reflected light with light reflected along a reference path to scan the tissue in depth. Since the reflection spectrum is sensitive to glucose concentration at particular wavelengths, measurement and analysis of the reflected light provides a measure of the level of glucose in the blood. The measurement of glucose is taken from multiple depths within blood-profused tissue, and sensitivity is preferably enhanced by the use of multiple wavelengths. Noise or speckle associated with this technique is minimized by continuously scanning the illuminated tissue in area and depth.

Systems and methods for enhancing knowledge discovery from data using multiple learning machines in general and multiple support vector machines in particular. Training data for a learning machine is pre-processed in order to add meaning thereto. Multiple support vector machines, each comprising distinct kernels, are trained with the pre-processed training data and are tested with test data that is pre-processed in the same manner. The test outputs from multiple support vector machines are compared in order to determine which of the test outputs if any represents a optimal solution. Selection of one or more kernels may be adjusted and one or more support vector machines may be retrained and retested. Optimal solutions based on distinct input data sets may be combined to form a new input data set to be input into one or more additional support vector machine. The methods, systems and devices of the present invention comprise use of Support Vector Machines for the identification of patterns that are important for medical diagnosis, prognosis and treatment. Such patterns may be found in many different datasets. The present invention also comprises methods and compositions for the treatment and diagnosis of medical conditions.

Disclosed are surgical tools, tool sets and methods for percutaneously accessing and preparing treatment sites within the spine for subsequent treatment procedures. The treatment site may be an inter-vertebral motion segments in the lumbar and sacral regions of the spine. The tool set may comprise introducer tools and bone dilators for accessing and tapping into a targeted site, such as, for example, the anterior surface of the S1 vertebral body. The tool set may also comprise cutters and extractors for preparing the treatment site for subsequent treatment procedures. The tool set may additionally comprise a bone graft inserter, an exchange system, and / or a temporary distraction tool for further preparing the treatment site for subsequent treatment procedures.

A fine particle producing process introduces a material for producing fine particles into a thermal plasma flame to make a vapor-phase mixture and quenches the vapor-phase mixture to form the fine particles. In the process, the material for producing the fine particles is dispersed or dissolved in a dispersion medium or solvent, preferably containing a combustible material to prepare a dispersion such as a slurry, a colloidal solution or a dissolution solution, the dispersion is made into a form of droplets, or the material for producing the fine particles is dispersed with a carrier gas and a combustible material and the dispersion in a droplet form or the dispersed material is introduced into the thermal plasma flame. In the fine particle producing process and apparatus, a gas of an amount sufficient to quench the vapor-phase mixture is supplied toward a tail of the thermal plasma flame. In the process and apparatus, primary fine particles are introduced into a cyclone to be subjected to cooling and classification and secondary fine particles having a particle size of 100 nm or less which are left upon removal of coarse particles are recovered.

An instrument is provided which is in electronic communication with an on board diagnostic system (OBD) of an automobile. The instrument selectively queries the OBD with batch requests for the purpose of reducing a processing load placed on the OBD PCM. The instrument obtains numerous operating conditions through the OBD, and displays the operating conditions in an intuitive format. The operating conditions may be grouped into five different modes, and the five most relevant operating conditions within each mode may be displayed on the monitor either by default or through customization by the user.

A system, method and computer program product for synchronizing replicas of shared data structures associated with one or more computer systems. The method comprises: evaluating a metric for performing a replica synchronization operation on a first computer system according to a first synchronization method; evaluating the metric for performing a replica synchronization operation on the first computer system according to a second synchronization method; and, selecting, at synchronization time, based on the evaluated metric, whether to use the first or second synchronization methods, and communicating a command to a second computer system to replicate a shared data structure based on the selected synchronization method.