365 results about "Needle biopsy" patented technology

A needle biopsy instrument for retrieving a tissue sample from an internal organ such as needle biopsy forceps, includes a pushing surface for safely dislodging a tissue sample from the needle after the instrument containing the sample is retrieved from the patient using mechanical control means operated from the proximal handle to thereby avoid the risk of accidental cuts, punctures and other injuries to medical personnel while trying to manually remove the sample. The instrument has a cam mechanism, or other mechanical links scissor links for operating the cups and producing relative movement between the pushing surface and axis of the needle to cause a tissue sample to be moved toward and eventually off of the tip of the needle into a sample receiving cup. An axial reciprocating control member attached to either the needle or the pushing surface produces the relative movement and is manually controlled by a handle or other grip at the proximal end of the forceps. The needle is either retracted axially from the distal toward the proximal end of the device, or a pushing member attached to the distal end of an actuating cable or cable is moved distally along the axis of a stationary needle. A latch mechanism can be provided on the proximal end to release a biasing force to provide the relative movement between the needle and pushing member to slide a tissue sample off the needle.

Implantable medical device eluting drug locally and in prolonged period is provided, including several types of such a device, the treatment modes of implementation and methods of implantation. The device comprising of polymeric substrate, such as a matrix for example, that is used as the device body, and drugs, and in some cases additional scaffolding materials, such as metals or additional polymers, and materials to enhance visibility and imaging. The selection of drug is based on the advantageous of releasing drug locally and in prolonged period, where drug is released directly to the extracellular matrix (ECM) of the diseased area such as tumor, inflammation, degeneration or for symptomatic objectives, or to injured smooth muscle cells, or for prevention. One kind of drug is the gene silencing drugs based on RNA interference (RNAi), including but not limited to si RNA, sh RNA, or antisense RNA / DNA, ribozyme and nucleoside analogs. The modes of implantation in some embodiments are existing implantation procedures that are developed and used today for other treatments, including brachytherapy and needle biopsy. In such cases the dimensions of the new implant described in this invention are similar to the original implant. Typically a few devices are implanted during the same treatment procedure.

Embodiments of a needle biopsy device having a rotating needle mechanism to automatically cut sample tissue that can be operated remotely. A portable small biopsy robot can improve biopsy accuracy, reduce the pain and complications, and shorten the duration of the total biopsy time by using an automatic needle rotating mechanism and a needle localization system that allows a medical practitioner to perform the biopsy procedure from a remote distance. The needle biopsy device can include a cannula and a rotational biopsy needle with a blade the rotational biopsy needle axially and rotatably moveable within the cannula lumen, the blade configured to remove, cut, and / or separate a tissue sample from the target tissue site through rotation of the blade, and to hold the tissue sample in the rotational biopsy needle during proximal retraction from the patient.

A medical instrument usable with an ultrasound-endoscope for performing a needle biopsy on a patient's internal body tissues usable at a surgical site not visible to the unaided eye or viewed endoscopically, comprises an elongate tubular member with a hollow needle element connected at its distal end, a sheath member housing said tubular member and needle element, an actuator subassembly with a shifter member operatively connected to elongate tubular member's proximal end, and a distal camming subassembly, said subassembly enabling a rotating motion of said needle member while handle actuator is moved in the forward direction. Upon inserting an ultrasound-endoscope into a patient and locating a mass, the fine needle with sharply pointed spoon shaped distal end is inserted into the mass aided by endoscopic and ultrasonographic guidance. Once in the mass, a camming action is initiated, causing rotation of the fine needle within the mass, resulting in a scooped out core biopsy. This instrument enables the performance of a fine needle aspiration requiring only one or two needle introductions, with a resultant core biopsy substantial enough for diagnostic purposes.

A training aid for teaching needle biopsy of the human breast. The inventive methods use breast models having lifelike properties providing accurate tactile sensation during palpation of the breast that enable a trainee to learn to locate modeled internal lesions and similar tissues in the breast. These same properties allow learning of tactile sensations indicating relative position and motion of biopsy needles during biopsy needling procedures. To facilitate tactile learning, the breast model includes an opaque skin that blocks the trainee view of a breast cavity containing modeled lesions, ensuring that needling procedures are performed based solely on "feel". The present invention also includes alternative training methods using a second breast model that is sufficiently transparent to allow viewing of modeled lesions from any relative position. The present invention includes training systems incorporating breast models and viewing stands and methods of training using these aids.

A medical instrument usable with an ultrasound-endoscope for performing a needle biopsy on a patient's internal body tissues usable at a surgical site not visible to the unaided eye or viewed endoscopically, comprises an elongate tubular member with a hollow needle element connected at its distal end, a sheath member housing said tubular member and needle element, an actuator subassembly with a shifter member operatively connected to elongate tubular member's proximal end, and a distal camming subassembly, said subassembly enabling a rotating motion of said needle member while handle actuator is moved in the forward direction. Upon inserting an ultrasound-endoscope into a patient and locating a mass, the fine needle with sharply pointed spoon shaped distal end is inserted into the mass aided by endoscopic and ultrasonographic guidance. Once in the mass, a camming action is initiated, causing rotation of the fine needle within the mass, resulting in a scooped out core biopsy. This instrument enables the performance of a fine needle aspiration requiring only one or two needle introductions, with a resultant core biopsy substantial enough for diagnostic purposes.

The invention provides a device for needle biopsy having a novel delivery handle system for interchangeably delivering needles of various sizes to a biopsy site. The delivery handle system is adjustable in length and includes a proximal handle member slideably disposed over a middle handle member, and the middle handle member is slideably disposed over a distal handle member. The proximal handle member includes an inner hub housing component configured to interchangeably receive a needle subassembly that can be inserting into and withdrawn from the proximal handle member. The needle subassembly includes a needle of a plurality of different sizes, a needle luer, a needle hub coupled to a proximal end portion of the needle, and a needle protector subassembly. The needle protector subassembly includes a needle protection hub configured to receive the distal end of a needle.

A device for needle biopsy is provided. The device includes a handle member having proximal and distal portions. A proximal handle member is disposed to the proximal portion of the handle member and a distal handle member is disposed to the distal portion of the handle member. A sheath lumen is disposed within the handle member and extends from the distal portion of the handle member. A needle housing member is partially disposed to the proximal portion of the handle member and a needle is disposed within the sheath lumen. A plurality of protrusions are disposed upon the needle.

A needle biopsy instrument for retrieving a tissue sample from an internal organ such as needle biopsy forceps, includes a pushing surface for safely dislodging a tissue sample from the needle after the instrument containing the sample is retrieved from the patient using mechanical control means operated from the proximal handle to thereby avoid the risk of accidental cuts, punctures and other injuries to medical personnel while trying to manually remove the sample. The instrument has a cam mechanism,or other mechanical links scissor links for operating the cups and producing relative movement between the pushing surface and axis of the needle to cause a tissue sample to be moved toward and eventually off of the tip of the needle into a sample receiving cup. An axial reciprocating control member attached to either the needle or the pushing surface produces the relative movement and is manually controlled by a handle or other grip at the proximal end of the forceps. The needle is either retracted axially from the distal toward the proximal end of the device, or a pushing member attached to the distal end of an actuating wire or cable is moved distally along the axis of a stationary needle. A latch mechanism can be provided on the proximal end to release a biasing force to provide the relative movement between the needle and pushing member to slide a tissue sample off the needle.

A device for needle biopsy is presented. The device includes a handle member having proximal and distal portions. A proximal handle member is disposed to the proximal portion of the handle member and a distal handle member is disposed to the distal portion of the handle member. A sheath lumen is disposed within the handle member and extends from the distal portion of the handle member. A needle housing member is partially disposed to the proximal portion of the handle member and a needle is disposed within the sheath lumen. A plurality of protrusions is disposed upon the needle. A needle protection member is partially disposed to the distal portion of the needle housing member. The needle protection member includes a needle protection hub and a needle protection shaft.

A device for needle biopsy and delivery of a diagnostic or therapeutic agent is presented. The device includes a handle member having proximal and distal portions. A proximal handle member is disposed to the proximal portion of the handle member and a distal handle member is disposed to the distal portion of the handle member. A sheath lumen is disposed within the handle member and extends from the distal portion of the handle member. A needle housing member is partially disposed to the proximal portion of the handle member and a needle is disposed within the sheath lumen. The needle housing member includes one or more ports for introducing an agent or a device into the housing member. The needle can include an agent or a device disposed at a distal portion thereof.

The present invention pertains to a remote center of motion robot for medical image scanning and image-guided targeting, hereinafter referred to as the “Euler” robot. The Euler robot allows for ultrasound scanning for 3-Dimensional (3-D) image reconstruction and enables a variety of robot-assisted image-guided procedures, such as needle biopsy, percutaneous therapy delivery, image-guided navigation, and facilitates image-fusion with other imaging modalities. The Euler robot can also be used with other handheld medical imaging probes, such as gamma cameras for nuclear imaging, or for targeted delivery of therapy such as high-intensity focused ultrasound (HIFU). 3-D ultrasound probes may also be used with the Euler robot to provide automated image-based targeting for biopsy or therapy delivery. In addition, the Euler robot enables the application of special motion-based imaging modalities, such as ultrasound elastography.

A transseptal needle includes an elongate needle body having a distal end and a proximal end and a cannular needle tip located proximate the distal end of the needle body. The needle tip has a distal segment, a proximal segment, and a longitudinal axis. An inner surface of the needle tip defines a passageway spanning at least a portion of the needle tip, and an outer surface of the needle tip defines a wall with the inner surface. The distal segment of the needle tip also includes a wedge surface and a dome-shaped region. The wedge surface forms a wedge angle of other than 90 degrees relative to the longitudinal axis. The dome-shaped region, which intersects the wedge surface, includes at least two bevels that intersect the wedge surface and that intersect each other at one or more points on the needle tip.

A needle biopsy guide system is disclosed for attachment to an endoluminal ultrasound probe or like sonographic instrument. The device includes a biopsy-guide attachment that allows for trocar catheter placement for abscess drainage or like procedures, using the transvaginal or transrectal route under sonographic control. The device has a base portion, which is attachable to an ultrasound probe. A removable retainer is provided that slides into the base unit to hold a biopsy needle in place. A physician may locate the target area in the body with the ultrasound probe, insert the biopsy needle into the target area, and then remove the insert (retainer) from the base unit and ultrasound probe, and leave the biopsy needle in place in the body.

A diagnostic cylindrical probe introduced through the body surfaces to the target tissue to detect the resistance of the tissues to piercing, its electrical activity and its resistance to passage of electrical current to identify the nature of the tissue and predict the nature of its pathology during needle biopsy has a sharp piercing tip attached to its end through a coiled wire to slide over the surface of an inbuilt changeable electrical resistance incorporated in an electrical circuit to detect the mechanical resistance of the tissues to piercing, a sensor at its tip incorporated in a second electrical circuit to detect the electrical impedance of the target tissue and a secondary electrically isolated sensor incorporated with the first sensor in a third electrical circuit to detect the electrical resistance of the tissues to passage of electrical current.

A surgical needle includes an elongated needle body defining a longitudinal y-axis along which the needle body extends and transverse x and z-axes. The needle body includes a central shaft portion, a first suture end portion for attachment to a suture and a second needled end portion for penetrating tissue. The needled end portion has three sides which intersect to define three cutting edges and terminate at a needle point. At least one side includes a pair of planar surface portions arranged in oblique relation to define a general concave appearance to the one side. The needled end portion further defines an enlarged transition portion adjacent the central shaft portion with at least an x-dimension greater than a corresponding x-dimension of the central shaft portion.

A biopsy needle (80) having a longitudinal channel (84) formed within an inner conductor (86) of a coaxial antenna is disclosed. The coaxial antenna terminates in a rigid insertion tip (82) e.g. a ceramic cone that is insertable into biological tissue. Microwave energy (e.g. having a frequency of 1 to 100 GHz) delivered to the coaxial antenna is emitted at the insertion tip. The insertion tip may be arranged to match the impedance of the coaxial antenna to a predetermined tissue impedance. The emitted radiation can be used to measure properties of or treat (e.g. ablate) tissue at the insertion tip. Needle biopsy apparatus is also disclosed, in which a microwave energy is controllably delivered to a needle from a microwave generator. The apparatus may include an impedance tuner to dynamically match the impedance of the needle with tissue at the insertion tip.

A phacoemulsification needle uses a variety of tip shapes to increase efficiency during surgery. In several variations the tips are angled with respect to the needle body. Inb others, various cross-sectional shapes are used. Angling the tip opening is another configuration used.

The invention discloses a macromolecular soluble microneedle used for polypeptide and protein medicines. The macromolecular soluble microneedle comprises a base as well as a needle body on the base and a needle point on the needle body, wherein the base and the needle body are made of a mixture of a high polymer material and a stabilizer; and solid active peptide or protein medicines are embedded into the needle point. The concentration degree of the medicines embedded in the needle point of the macromolecular soluble microneedle is relatively high, and nearly no residual medicines exist on the bottom of the needle body, so that the administration efficiency and the administration accuracy are greatly improved; in addition, the part entering the subcutaneous tissue of the needle body can rapidly dissolve, and further degrade to be completely absorbed by the tissues without toxic or side effects, so that the possible needle breaking risk existing in the microneedle made of other materials such as metal, glass and silicon is avoided. The preparation method of the macromolecular soluble microneedle is carried out under simple technological conditions, is low in price, and suitable for volume production, and the macromolecular soluble microneedle can be widely applied to the field of cutaneous penetration of macromolecular medicines.

A handheld optical coherence tomography imaging and tissue sampling system and method of imaging and sampling a tissue is disclosed. The method includes inserting a catheter probe into a biopsy needle. The biopsy needle can be attached to a hand-held scanning and sampling device. The biopsy needle is maneuvered to an investigation site. A three-dimensional image of the tissue at the investigation site is captured with the catheter probe.

The invention relates to incision biopsy of the tissue that is collected in the tissue aspiration reservoir (19) that is administered by forward motion of the cutting inner edge (21), after the aspiration of the fluid material into the inner needle inlet (22) and the conveying space (23), and from there into the outlet (27) and the hollow of injection syringe (17) as a result of the vacuum that is created by opening of the notch (13) at the tip of the outer needle (10), with backward motion of the cutting inner needle (20) that is connected with the moveable piston that is positioned in the hollow (11) of the outer needle (10) that is connected with the said injection syringe body (16).

Clinical information, molecular information and / or computer-generated morphometric information is used in a predictive model for predicting the occurrence of a medical condition. In an embodiment, a model predicts whether a disease (e.g., prostate cancer) is likely to progress in a patient after radiation therapy. In some embodiments, the molecular and computer-generated morphometric information is obtained through computer analysis of tissue obtained from the patient via a needle biopsy at diagnosis and before treatment of the patent with radiation therapy.

The invention belongs to the technical field of administration equipment, and relates to a macromolecule solid micro needle and a batched preparing method thereof. The macromolecule solid micro needle is composed of a base and needle body arrays distributed on the base. The height of each needle body in each needle body array is 200-900 microns, the distance between needle points is 200-600 microns, and the diameter of the bottom of each needle body is 30-800 microns. The size of each needle body array is 5 mm*5 mm to 10 cm*10 cm. Compared with the prior art, the macromolecule solid micro needle solves the key problems that in the current beautifying nutrient substance and medicine transdermal releasing technology, due to the shielding function of the cuticle in the skin cuticular layer, the substance transdermal absorption is difficult, and a human body can feel painful and discomfortable. Thus, the macromolecule solid micro needle is good in durability and low in cost, the manufacturing technology of the macromolecule solid micro needle is simple, and the macromolecule solid micro needle is suitable for batched production.

An image-guided system and method for performing needle biopsy on a moving lung nodule of a body is provided. CT images of the lung nodule are obtained to generate a motion model, based on which an optimal needle advancing path is determined. The motion of the lung nodule and the motion of a fiducial marker attached to the body are correlated. The motion of the fiducial marker is tracked and monitored by a camera to determine a position of the lung nodule based on the correlation. A time for advancing the needle is determined based on a motion attribute of the reference. The needle is advanced by a robotic needle manipulator at the predetermined time along the path to accomplish the needle placement.

A phacoemulsification needle having a hollow passageway terminates in a straight needle tip formed off-axis from the passageway, allowing the needle tip to move eccentrically when the needle is subjected to torsional or longitudinal vibratory motion. The tip may be flared or may be coextensive with the needle body. The aspiration passageway formed through the needle body may be formed off-axis from the needle body axis. The tip may also be angled with respect to the needle body. The inner and outer surfaces of the needle tip are roughened, as by sandblasting, to enhance the cutting effect of the tip when used with a non-longitudinal handpiece. The lip of each needle tip is polished to a high degree of smoothness and the edges of the tip are rounded to lessen the incidence of snags or cuts.

A device for needle biopsy is presented. The device includes a handle member having proximal and distal portions. A proximal handle member is disposed to the proximal portion of the handle member and a distal handle member is disposed to the distal portion of the handle member. A sheath lumen is disposed within the handle member and extends from the distal portion of the handle member. A needle housing member is partially disposed to the proximal portion of the handle member and a needle is disposed within the sheath lumen. A plurality of protrusions is disposed upon the needle. A needle protection member is partially disposed to the distal portion of the needle housing member. The needle protection member includes a needle protection hub and a needle protection shaft.

This document provides medical device systems and methods for obtaining tissue samples. For example, this document provides medical device systems and methods for transbronchial needle biopsy tissue acquisition. In some cases, a needle biopsy system includes an actuator device, an outer needle with a lumen therethrough, and an inner needle at least partially disposed within the lumen. The outer needle can extend distally from the actuator device. A distal tip of the inner needle can be capable of being fully disposed within the lumen. The inner needle can extend distally from the actuator device. The actuator device can be configured to translate the outer needle proximally and distally. The actuator device can be configured to translate the inner needle proximally and distally independently of the outer needle.

A tilted needle biopsy assembly is provided for mounting on an x-ray system. Because the biopsy needle is angied relative to at least one of the detector and the x-ray source, x-ray imaging may be performed during the biopsy procedure without interference by the biopsy device. The angled biopsy needle additionally allows improved access to the axilla and chest wall of the patient. The stereotactic biopsy device of the present invention may be coupled to any x-ray system, whether upright or prone, including but not limited to mammography systems, tomosynthesis systems, and combination mammography / tomosynthesis systems. The system flexibly supports the use of any mode of image capture (i.e., scout, two dimensional mammogram, three-dimensional reconstructed volume) for either or both target visualization and target localization. With such an arrangement, a needle biopsy assembly having improved patient coverage is provided for use with a variety of different x-ray imaging platforms.