50 results about "Synthetic drug" patented technology

The present invention relates to a process of a chemically synthetic drug, and in particular, to a new intermediate of a heparin pentasaccharide and a preparation method thereof. The process has high reaction efficiency, and an easy reaction operation. The reaction intermediate is easy to be purified, and is appropriate for an industrialization production.

The invention discloses a preparing method by using unactivated olefin hydrogen trifluoride methylation and application thereof. The method comprises the following steps: A, adding unactivated olefin I, sodium trifluoromethanesulfonate and a photocatalystIr[dF(CF3)ppy]2(dtbpy)PF6 into a Schlenk tube; B, vacuumizing, replacing argon, adding methyl alcohol; C, irradiating the Schlenk tube with a fluorescent lamp, and stirring to react; and D, after reaction is finished, adding water into the system to perform a quenching reaction, extracting with ethyl acetate, separating an organic phase, drying, filtering, performing rotary evaporation to remove a solvent, chromatographing the residue through an ethyl acetate / petroleum ether mixed solvent to obtain a target product II, wherein the proportion of the ethyl acetate / petroleum ether mixed solvent is selected according to different polarities of the product, and silica gel is adopted as a solid phase in column chromatography. The method applied to medicinal molecule synthesis is feasible, is simple and convenient to operate, and is used for implementing an unactivated olefin hydrogen trifluoride methylation reaction to prepare a series of trifluoromethyl-containing target compounds by selecting low-price trifluoromethyl reagent under a mild condition.

This invention is drawn to compounds which are more easily metabolized by the metabolic drug detoxification systems. Particularly, warfarin analogs which have been designed to include esters within the structure of the compounds are taught. The invention teaches methods of reducing the toxicity of drugs comprising the introduction of ester groups into drugs during the synthesis of the drug. This invention is also drawn to methods of treating coagulation disorders comprising the administration of compounds which have been designed to be metabolized by serum or intracellular hydrolases and esterases. Pharmaceutical compositions of the ester containing warfarin, analogs are also taught.

The invention provides an aromatic phenolic compound for room-temperature phosphorescence detection of drug gas and a sensing film and application thereof. The aromatic phenolic compound has a structure as shown in a formula I. Organic matter in the film comprises a conjugated aromatic macrocyclic compound containing a phenolic hydroxyl group, meanwhile, an aromatic ring further comprises an electron-withdrawing substituent group, a proper solvent is selected to prepare a solution, then the sensing film is prepared through dispensing, dip-coating or spin-coating and other methods, the film can sense drug gas. Research finds that the sensed film has room temperature phosphorescence, so that the sensing process can be monitored by monitoring the change of the intensity of the room temperature phosphorescence, and room temperature phosphorescence sensing has the advantages of high sensitivity, high selectivity, high response speed and strong anti-interference capability; according to the aromatic phenolic sensing film provided by the invention, room-temperature phosphorescent efficient detection of synthetic drugs represented by methamphetamine can be realized, and the aromatic phenolic sensing film is expected to be applied to drug enforcement work of public security departments in the future.

The invention relates to drug toothpaste for treating oral diseases and a preparation method thereof. The drug toothpaste is new type toothpaste adopting Chinese medicines including paeonol, and the like as main drug-effect ingredients and serving with anti-allergic and anti-hemostatic drug-effect ingredients. Compared with other chemical synthetic drugs, the drug toothpaste has the characteristics of small irritation and small toxic and side effects. The drug toothpaste has the functions for treating oral diseases, such as dental arthritis, toothache, hemodia, and the like. With long-term use, the drug toothpaste can improve oral environment and maintains oral health. The drug toothpaste has the advantages of reasonable formula, simple process and significant effect.

The invention relates to a Prunus padus L. anthocyanin-containing health product for preventing Alzheimer's disease. The health product comprises the following ingredients, by weight, 30-50% of Prunus padus L. anthocyanin, 10-30% of Prunus padus L. polysaccharide, 5-15% of sorghum rice polypeptide, 5-15% of Chinese chestnut polypeptide, 5-10% of a Chinese yam extract product, 5-10% of a Poria cocos extract product, 5-10% of a Ligusticum wallichii extract product and 5-10% of a dwarf lilyturf root extract product. Through in vitro experiment and animal experimental research on the product's function of preventing Alzheimer's disease, it is found that the health product has activity and function for preventing Alzheimer's disease and can replace chemical synthetic drugs so as to avoid toxic and side effect caused by excessive chemical synthetic drugs. Thus, a Prunus padus L. anthocyanin composition has a wider development prospect and can become a newly-developing component applied in health products.

The invention belongs to the technical field of traditional Chinese medicines and discloses a medicine for treating urinary system damage diseases caused by synthetic drug ketamine dependence. The medicine mainly comprises, by weight, 28-32 parts of Lygodium japonicum, 28-32 parts of lalang grass rhizome, 10-14 parts of sargentgloryvine stem, 23-27 parts of prepared rehmannia root, 10-14 parts ofChinese yam, 7-8 parts of rhizoma alismatis, 13-17 parts of giant knot weed, 10-14 parts of pulp of dogwood fruit, 8-12 parts of ligusticum wallichii, 8-10 parts of moutan bark, 8-10 parts of poria cocos and 13-17 parts of dandelion. The invention also discloses a preparation method and use of the medicine. The medicine has the remarkable curative effect on the symptoms of lower urinary tract injury caused by ketamine abuse, quickly relieves urinary tract irritation symptoms such as odynuria, urgent urination, frequent micturition and hematuresis and reduces the use of antibiotics and hormones.