34results about How to "Inhibit necrosis" patented technology

The invention relates to a compound 11-deoxy-18 alpha glycyrrhetinic acid derivative in a formula II, and application thereof in the fields of hepatic injury treatment, anti-inflammatory and the like. The invention relates to a preparation method of the glycyrrhetinic acid ester derivative.

The invention relates to application of a natural compound in relieving glucocorticoid side effects.

The invention discloses a drug for treating acute cerebral infarction. The drug is prepared from the following raw materials in parts by weight: 0.3-0.45 part of musk, 120-180 parts of radix astragali, 0.5-0.75 part of borneol , 6-9 parts of angelica angelica, 6-9 parts of radix paeoniae rubra, 3-4.5 parts of semen persicae, 3-4.5 parts of safflower, 3-4.5 parts of rhizoma chuanxiong and 3-4.5 parts of pheretima. The drug has the efficacies of restoring consciousness, enlightening brain, tonifying vital energy, promoting blood circulation and removing meridian obstruction, is capable of effectively inhibiting nerve dysfunctions such as ischemia, anoxia and necrosis of brain tissues, has very good effects on the treatment of symptoms such as headache, dizziness, facial paralysis, dysphasia,slobbering, hemiplegia, frequent urination or urinary incontinence, has no toxic and side effects and is safe and reliable.

The invention discloses a bursaphelenchus xylophilus effector protein BxSCD1 and application thereof, and belongs to the technical field of molecular biology. The amino acid sequence of the bursaphelenchus xylophilus effector protein BxSCD1 is as shown in SEQ ID No. 1, and the nucleotide sequence for expressing the protein is as shown in SEQ ID No. 2. The BxSCD1 is mainly located to cytoplasm, cysteine on the 117 site and cysteine on the 153 site take an important effect on structural stability of the BxSCD1, and the BxSCD1 can inhibit cytonecrosis and basic defense response caused by a bursaphelenchus xylophilus primordial associated molecular pattern (PAMP) BxCDP1 in nicotiana benthamiana and host pine trees. According to the invention, the interaction between the bursaphelenchus xylophilus and the host pine trees is discussed from inhibition of the plant immunoreaction by the effector secreted by the bursaphelenchus xylophilus, and the bursaphelenchus xylophilus effector protein BxSCD1 has the important significance for revealing the pathogenesis of the bursaphelenchus xylophilus, early detecting the occurrence of the bursaphelenchus xylophilus disease and the like.

The invention discloses application of collagen targeted vascular endothelial growth factors in old myocardial infarction treatment. In the application, the collagen targeted vascular endothelial growth factors are fused proteins obtained by fusing collagen binding regions at the ends N and / or C of the vascular endothelial growth factors, the vascular endothelial growth factors are proteins shownfrom the first site to the 166th site with the amino acid sequence of SEQ ID No.1, and the collagen binding regions are proteins shown from the 178th site to the 184th site with the amino acid sequence of SEQ ID No.1. It is shown through experiments that the collagen targeted vascular endothelial growth factors have the capacity of being combined with a cell epimatrix and can be specifically combined with an ischemia cardiomyocyte epimatrix, the myocardial ischemic injury repairing effect is improved, the side effects of VEGF high-dosage medicine application can be avoided, and the collagen targeted vascular endothelial growth factors can be used for treating the old myocardial infarction.

The invention discloses a compound ketoconazole lotion for hair. The compound ketoconazole lotion comprises, by weight, 1-2% of ketoconazole, 0.02-0.03% of clobetasol propionate, 20-26.5% of surfactant, 3-7% of cosurfactant, 0.2-0.5% of conditioner, 6-10% of foaming agent, 0.05-0.15% of ethylenediamine tetraacetic acid disodium salt, 0.5-3% of antioxidant, 0.01-0.03% of pigment and the balance purified water. Accessories used in the compound ketoconazole lotion for hair include the surfactant, the cosurfactant, the conditioner, the foaming agent, the antioxidant and the ethylenediamine tetraacetic acid disodium salt serving as the antioxidant synergist, the stabilizer and the softener. A proper number of accessories are matched with the ketoconazole and the clobetasol propionate so that the characters and the performance of the compound ketoconazole lotion for hair can be stable, the antibacterial activity of the ketoconazole and the clobetasol propionate can be brought into full play, in addition, compound ketoconazole lotion does not contain silicone oil or essence, the hair quality can be well conditioned, and the hair follicles cannot be damaged.

The invention discloses a chitosan-polypropylene carbonate composite medical dressing and a preparation method. The present invention uses polypropylene carbonate as the base film of the dressing, which helps to reduce the discharge of medical solid waste and the application of petrochemical products; the air permeability of the polypropylene carbonate film is improved by making holes through the pore-forming agent; Dopamine is used as a bionic bioadhesive to connect hydrophilic and degradable biomaterial chitosan to hydrophobic polypropylene carbonate, and modify it by polydopamine and chitosan to improve its physical properties as a dressing, Biological properties; and using spermidine as a cross-linking agent, on the one hand, chitosan can be better fixed on the surface of PPC through secondary cross-linking, and on the other hand, the bioactive small molecule spermidine is introduced to improve the rejection of the wound Inflammatory response helps to shorten wound repair time and reduce scar formation.

The invention relates to an unguent for treating scalds and preparation and application methods thereof. The unguent comprises the following raw materials in parts by weight: 32-48 parts of glutton fat, 32-48 parts of giant salamander meat, 12-18 parts of sesame oil, 1.6-2.4 parts of rhizoma polygoni cuspidati, 1.6-2.4 parts of radix scutellariae and 0.8-1.2 parts of borneol. The preparation method of the unguent for treating scalds comprises pre-treating raw materials, grinding, fermenting and stirring into a plaster. The application method comprises the step of directly applying the unguent at a scalded wound surface, or after applying the unguent to gauze or making the unguent into ointment gauze, applying to the scalded wound surface. The unguent for treating scalds and the preparation and application methods thereof has the beneficial effects that according to related theories of traditional Chinese medicine that lung governs skin and hair and gallbladder governs balance, the herbs are used together and reasonably compatible to achieve definite curative effects; when applied to a scald, the unguent can relieve pain and prevent infection, also inhibit the scald surface of a patient from necrocytosis and accelerate cell division, is high in efficiency and avoids scars after curing.

The invention discloses a combined medicine for treating acute viral hepatitis, which comprises the following raw materials in parts by weight: 0.01-0.02 parts of adefovir, 15-20 parts of rhubarb, 15-20 parts of licorice, and 15-20 parts of forsythia 20 parts, 15‑20 parts of Atractylodes macrocephala, 15‑20 parts of Desmodium, 15‑20 parts of Banzhilian, 15‑20 parts of Curcuma, 15‑20 parts of raspberry, 15‑20 parts of corn silk. The preparation method of the combined medicine is as follows: firstly, the raw medicinal material is extracted with 10 times the weight of 80% ethanol under reflux, extracted for 2 hours, filtered, the dregs are retained, the ethanol extract is collected, and the ethanol is recovered under reduced pressure, and then further concentrated to a thick paste , vacuum or microwave drying to obtain a dry extract; then add 8 times the weight of water to the dregs to decoct and extract twice, each time for 1.5 to 2 hours, filter, combine the water extracts, concentrate under reduced pressure to a thick paste, vacuum or Microwave drying to obtain dry extracts; combine the obtained extracts, crush them, add adefovir, and then add starch or dextrin to mix evenly, make tablets, granules or capsules, and pack them separately.

The invention relates to the field of biotechnology and aims at providing an application of AIF1 (Allograft Inflammatory Factor 1) protein and antibody to preparing a southern oyster anti-infectious immune preparation. The amino acid sequence of the protein is shown in SEQ ID NO.2; the open reading frame nucleotide sequence of the protein is shown in SEQ ID NO.1; and the application of the protein to preparing the southern oyster anti-infectious immune preparation is as follows: immunizing a New Zealand white rabbit by use of the protein so as to obtain polyclonal antiserum. According to the invention, the open reading frame complete sequence of a southern oyster AIF1 gene is obtained; and by virtue of constructing a prokaryotic expression vector, a soluble AIF1 protein product is expressed and purified, and the polyclonal antiserum is prepared; and the polyclonal antiserum has an effect of restraining inflammatory reactions caused by a southern oyster pathogeny RLO (Rickettsia-Like Organism) and gram-negative bacterium LPS (Lipopolysaccharide), as well as cytoclasis and apoptosis.

The invention belongs to the technical field of bio-pharmaceuticals and relates to a pharmaceutical composition containing miRNA-873 and application thereof. In a milliliter of the pharmaceutical composition containing miRNA-873, the content of 1,2-dioleoyl-3-trimethylaminepropane is 0.5-25mg, the molar ratio of miRNA-873 to 1,2-dioleoyl-3-trimethylaminepropane is 1:(150-205), the content of DC cholesterol is 0.1-5mg, the content of 1,2-dioleoyl-3-phosphatidyl ethanolamine is 0.1-20mg, the content of polyethylene glycol 2000 is 1-80mg, and the pharmaceutical composition also comprises the balance of phosphate buffer. The pharmaceutical composition is used for treating heart diseases such as myocardial infarction, myocardial ischemial injury, cardiac hypertrophy or myocardial fibrosis; and moreover, the pharmaceutical composition is simple in preparation process, obvious in drug effect, convenient to use and friendly in treatment environment.

The invention provides a dipeptide derivative for improving liver function, and its application, specifically an N-substituted 2(1H) dipeptide derivative and its pharmaceutically acceptable salt, and pharmaceutical composition containing the compound. The compound can effectively improve liver function, to lower alanine aminotransferase (ALT), aspartate aminotransferase (AST) and / or total bilirubin (Tbil). The compound can greatly improve survival rate of liver failure patient.

The invention belongs to the technical field of bio-pharmaceuticals and relates to a pharmaceutical composition containing miRNA-873 and application thereof. In a milliliter of the pharmaceutical composition containing miRNA-873, the content of 1,2-dioleoyl-3-trimethylaminepropane is 0.5-25mg, the molar ratio of miRNA-873 to 1,2-dioleoyl-3-trimethylaminepropane is 1:(150-205), the content of DC cholesterol is 0.1-5mg, the content of 1,2-dioleoyl-3-phosphatidyl ethanolamine is 0.1-20mg, the content of polyethylene glycol 2000 is 1-80mg, and the pharmaceutical composition also comprises the balance of phosphate buffer. The pharmaceutical composition is used for treating heart diseases such as myocardial infarction, myocardial ischemial injury, cardiac hypertrophy or myocardial fibrosis; and moreover, the pharmaceutical composition is simple in preparation process, obvious in drug effect, convenient to use and friendly in treatment environment.