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Combination drug for treating acute viral hepatitis

A viral hepatitis and drug technology, applied in antiviral agents, drug combinations, pharmaceutical formulations, etc., can solve problems such as renal damage in patients, and achieve the effects of less renal damage, enhanced immunity, and less drug resistance.

Inactive Publication Date: 2015-07-08
程厚华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In actual treatment, antiviral drugs have strong side effects and drug resistance, and will also cause damage to the patient's kidney function

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Weigh the following Chinese medicinal materials by weight: 150 grams of rhubarb, 150 grams of licorice, 150 grams of forsythia, 150 grams of Atractylodes macrocephala, 150 grams of money grass, 150 grams of Scutellaria barbata, 150 grams of turmeric, 150 grams of raspberry, and 150 grams of corn silk .

[0028] Prepare as follows:

[0029] (1) The raw medicinal materials are extracted with 14L of 80% ethanol under reflux, extracted for 2 hours, filtered, the dregs are retained, the ethanol extract is collected, and after the ethanol is recovered under reduced pressure, it is further concentrated to a thick paste, vacuum or microwave dried, and dried extract;

[0030] (2) decocting and extracting the medicinal dregs retained in step (1) with 12 L of water twice, each time for 2 hours, filtering, combining the water extracts, concentrating under reduced pressure to a thick paste, and drying in vacuum to obtain a dry extract;

[0031] (3) Combine the extracts obtained in...

Embodiment 2

[0033] Weigh the following Chinese medicinal materials by weight: 200 grams rhubarb, 200 grams licorice, 200 grams forsythia, 200 grams Atractylodes macrocephala, 200 grams desmodium, 200 grams barbata, 200 grams turmeric, 200 grams raspberry, 200 grams corn silk .

[0034] Prepare as follows:

[0035] (1) The raw medicinal materials are extracted with 18L of 80% ethanol under reflux, extracted for 2 hours, filtered, the dregs are retained, the ethanol extract is collected, and after the ethanol is recovered under reduced pressure, it is further concentrated to a thick paste, vacuum or microwave dried, and dried extract;

[0036] (2) decocting and extracting the medicinal dregs retained in step (1) with 15 L of water twice, each time for 2 hours, filtering, combining the water extracts, concentrating under reduced pressure to a thick paste, and drying in vacuum to obtain a dry extract;

[0037] (3) Combine the extracts obtained in steps (1) and (2), crush them, add 0.2 g of ...

Embodiment 3

[0039] Weigh the following Chinese medicinal materials by weight: 180 grams of rhubarb, 180 grams of licorice, 180 grams of forsythia, 180 grams of Atractylodes macrocephala, 180 grams of money grass, 180 grams of Scutellaria barbata, 180 grams of turmeric, 180 grams of raspberry, 180 grams of corn silk .

[0040] Prepare as follows:

[0041] (1) The raw medicinal materials are extracted with 16L of 80% ethanol under reflux, extracted for 2 hours, filtered, the dregs are retained, the ethanol extract is collected, and after the ethanol is recovered under reduced pressure, it is further concentrated to a thick paste, vacuum or microwave dried, and dried extract;

[0042] (2) decocting and extracting the medicinal residues retained in step (1) with 13 L of water twice, each time for 2 hours, filtering, combining the water extracts, concentrating under reduced pressure to a thick paste, and vacuum drying to obtain a dry extract;

[0043] (3) Combine the extracts obtained in ste...

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PUM

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Abstract

The invention discloses a combination drug for treating acute viral hepatitis. The combination drug comprises the following active ingredients in parts by weight: 0.01-0.02 part of adefovir, 15-20 parts of rheum officinale, 15-20 parts of liquorice, 15-20 parts of fructus forsythia, 15-20 parts of white atractylodes rhizome, 15-20 parts of herba lysimachiae, 15-20 parts of sculellaria barbata, 15-20 parts of radix curcumae, 15-20 parts of raspberry and 15-20 parts of corn stigma. The preparation method of the combination drug comprises the following steps: performing reflux extraction on the raw materials by 10 times of 80% ethanol, extracting for 2h, filtering, keeping the residues, collecting the ethanol extract, decompressing and recovering the ethanol, further condensing to get a thick paste, performing vacuum or microwave drying to obtain a dry extract; adding 8 times of water to the residues, decocting and extracting for 2 times with each time for 1.5-2h, filtering, combining the water extracts, decompressing and condensing to get the thick paste, performing vacuum or microwave drying to obtain the dry extract; and combining the extracts, smashing, adding the adefovir, adding the starch or dextrin, and mixing uniformly to obtain a tablet, a granule or a capsule, and packaging.

Description

technical field [0001] The invention relates to a combined medicine, in particular to a combined medicine for treating acute viral hepatitis. Background technique [0002] Acute viral hepatitis refers to a wide range of liver inflammatory diseases caused by specific hepatotropic viruses. The incubation period is between 15 and 45 days, with an average of 25 days, and the total course of disease is 2 to 4 months. There are five types of hepatitis A, B, C, D, and E, and A and E are acute hepatitis with a short incubation period. The main symptoms of viral hepatitis are fatigue, loss of appetite, and abnormal liver function. Some patients may have fever and jaundice. Severe hepatitis is dangerous and has a high mortality rate. The main causes of death were hepatic coma, liver failure, electrolyte disturbance and secondary infection. There is no cross-immunity between various types of hepatitis, and they can be infected simultaneously or successively, mixed infection or overl...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61P1/16A61P31/14A61P31/20A61K31/675
Inventor 程厚华
Owner 程厚华
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