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Application of berberine in preparation of drug for treating viral myocarditis diseases caused by coxsackie virus B3

A coxsackie virus, a virus-causing technology, applied in the field of medicine, can solve the problem that the anti-viral mechanism has not been fully elucidated

Active Publication Date: 2015-07-08
THE SECOND AFFILIATED HOSPITAL ARMY MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Relevant studies in recent years have shown that berberine has anti-influenza virus activity, but its specific anti-viral mechanism has not been fully elucidated
However, the research of berberine against other viruses is still very rare.
Especially for anti-Coxsackie virus B3 activity has not yet been reported

Method used

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  • Application of berberine in preparation of drug for treating viral myocarditis diseases caused by coxsackie virus B3
  • Application of berberine in preparation of drug for treating viral myocarditis diseases caused by coxsackie virus B3
  • Application of berberine in preparation of drug for treating viral myocarditis diseases caused by coxsackie virus B3

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0026] 1. Materials and reagents

[0027] 1. Animals, virus strains

[0028] BALB / c mice, male, 4-6 weeks old, were purchased from the Animal Center of Daping Hospital, Third Military Medical University;

[0029] Coxsackie virus B3 (Nancy) was purchased from Wuhan Institute of Virology, Chinese Academy of Sciences;

[0030] HeLa cell lines were purchased from the Cell Resource Center, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences.

[0031] 2. Main reagents

[0032]

[0033] PBS solution (0.01mol / L, pH 7.4): NaCl 8.00g, KCl 0.20g, KH 2 PO 4 0.20g, NaH 2 PO 4 ·H 2 O 1.56g, 1000ml ddH 2 Dissolve in O, sterilize under high temperature and high pressure, and store at 4°C.

[0034] 3. Main instruments and equipment

[0035]

[0036] 2. Experimental method

[0037] 1. Establishment of viral myocarditis model

[0038] BALB / c mice, male, 4-6 weeks old, were adaptively fed for 3 days. The experiment was divided into normal control group, vir...

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Abstract

The invention relates to an application of berberine in preparation of a drug for treating viral myocarditis diseases caused by coxsackie virus B3. By means of the drug for treating the viral myocarditis diseases caused by the coxsackie virus B3, an effect of anti-CVB3 is achieved and an effect of inhibiting the expression of a proinflammatory factor and a chemotactic factor is significant, so that the berberine can be used for preparing the drug for treating the viral myocarditis diseases. The drug is less in side effects, is high in curative effects and is excellent in application prospect since a drug in the prior art is not satisfied in clinical treatment effects of the treatment, especially of the treatment in the later period of infection, of the viral myocarditis diseases caused by the coxsackie virus B3 (CVB3).

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the use of berberine for preparing a medicine for treating viral myocarditis caused by Coxsackievirus B3. Background technique [0002] Viral myocarditis (viral myocarditis) refers to a disease caused by cardiotropic virus infection, mainly caused by myocardial inflammatory lesions, which can cause acute cardiac insufficiency, and about 1 / 3 of the patients further develop into chronic myocarditis and dilated cardiomyopathy. It is one of the common causes of heart failure. In recent years, the incidence of this disease has been on the rise, and it has become one of the common diseases that endanger human health. But so far there is no specific treatment. Therefore, it is an urgent clinical need to find new drugs with definite curative effect to prevent and treat viral myocarditis. [0003] A variety of viral infections can cause viral myocarditis. The currently known related...

Claims

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Application Information

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IPC IPC(8): A61K31/4375A61P9/00A61P9/04
Inventor 张克斌代黔钱桂生周世文余华张迪何晓梅熊浚智辛榕谢玮
Owner THE SECOND AFFILIATED HOSPITAL ARMY MEDICAL UNIV
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