The invention, which relates to the technical field of
biomedicine, provides a piezoelectric
stent composition capable of realizing self-generating
electricity stimulation as well as a preparation method and application thereof. The composition is composed of a biodegradable metabolic material and a piezoelectric material. With a 3D printing, jetting, pouring, extruding, die forming or electrostatic
spinning method, the co-melt of the biodegradable material and the piezoelectric material or an
organic solvent is formed into various biomedical application stents, especially nerve conduit stents. According to the invention, the
mechanical energy in an in-vivo environment can be into electrical stimulation to promote regeneration, proliferation and differentiation of nerves, muscles, bones, blood vessels and the like without implantation of an external power supply or an
electrode. The piezoelectric
stent composition has advantages of being simple to prepare, low in cost, easy to controlin quality, wide in application range and the like. Rat in-vivo experiments show that the piezoelectric
catheter stent has functions of promoting nerve regeneration and
angiogenesis, relieving muscleatrophy and the like and has the broad clinical application prospects.